Pharmacological treatment algorithms for the acute phase, agitation, and maintenance phase of first‐episode schizophrenia: Japanese Society of Clinical Neuropsychopharmacology treatment algorithms.
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| Title: | Pharmacological treatment algorithms for the acute phase, agitation, and maintenance phase of first‐episode schizophrenia: Japanese Society of Clinical Neuropsychopharmacology treatment algorithms. |
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| Authors: | Takeuchi, Hiroyoshi (AUTHOR), Takekita, Yoshiteru (AUTHOR), Hori, Hikaru (AUTHOR), Oya, Kazuto (AUTHOR), Miura, Itaru (AUTHOR), Hashimoto, Naoki (AUTHOR), Yasui‐Furukori, Norio (AUTHOR) |
| Source: | Human Psychopharmacology: Clinical & Experimental. Nov2021, Vol. 36 Issue 6, p1-9. 9p. |
| Subjects: | Drug therapy, Aripiprazole, Neuropsychopharmacology, Patient compliance, Patient preferences, Schizophrenia |
| Abstract: | Objective: There are only a few treatment algorithms for first‐episode schizophrenia. Moreover, all the algorithms apply to acute treatment, but not maintenance treatment. Therefore, we aimed to develop acute and maintenance treatment algorithms for first‐episode schizophrenia. Methods: The algorithm committee of the Japanese Society of Clinical Neuropsychopharmacology developed pharmacological treatment algorithms for the acute phase, agitation, and maintenance phase of first‐episode schizophrenia. Results: The acute treatment algorithm focuses on drug‐naïve patients with first‐episode schizophrenia who are not old or very agitated and recommends first‐line treatment with aripiprazole, second‐ or third‐line treatment with risperidone/paliperidone or olanzapine, and fourth‐line treatment with clozapine. Long‐acting injection of the current antipsychotic agent can be used for poor medication adherence or based on patient preference. The agitation treatment algorithm recommends first‐line treatment with lorazepam and second‐ or third‐line treatment with quetiapine or levomepromazine and clearly instructs that the medication used for agitation should be reduced and then discontinued after remission of agitation. The maintenance treatment algorithm recommends the gradual reduction of antipsychotics to the minimum effective dose after remission of positive symptoms. Conclusions: We hope that our unique algorithms will be used broadly and will contribute to minimizing patients' burden related to antipsychotic treatment. [ABSTRACT FROM AUTHOR] |
| Copyright of Human Psychopharmacology: Clinical & Experimental is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 153385231 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Pharmacological treatment algorithms for the acute phase, agitation, and maintenance phase of first‐episode schizophrenia: Japanese Society of Clinical Neuropsychopharmacology treatment algorithms. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Takeuchi%2C+Hiroyoshi%22">Takeuchi, Hiroyoshi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Takekita%2C+Yoshiteru%22">Takekita, Yoshiteru</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hori%2C+Hikaru%22">Hori, Hikaru</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Oya%2C+Kazuto%22">Oya, Kazuto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Miura%2C+Itaru%22">Miura, Itaru</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hashimoto%2C+Naoki%22">Hashimoto, Naoki</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yasui‐Furukori%2C+Norio%22">Yasui‐Furukori, Norio</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Human+Psychopharmacology%3A+Clinical+%26+Experimental%22">Human Psychopharmacology: Clinical & Experimental</searchLink>. Nov2021, Vol. 36 Issue 6, p1-9. 9p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Drug+therapy%22">Drug therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Aripiprazole%22">Aripiprazole</searchLink><br /><searchLink fieldCode="DE" term="%22Neuropsychopharmacology%22">Neuropsychopharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+compliance%22">Patient compliance</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+preferences%22">Patient preferences</searchLink><br /><searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objective: There are only a few treatment algorithms for first‐episode schizophrenia. Moreover, all the algorithms apply to acute treatment, but not maintenance treatment. Therefore, we aimed to develop acute and maintenance treatment algorithms for first‐episode schizophrenia. Methods: The algorithm committee of the Japanese Society of Clinical Neuropsychopharmacology developed pharmacological treatment algorithms for the acute phase, agitation, and maintenance phase of first‐episode schizophrenia. Results: The acute treatment algorithm focuses on drug‐naïve patients with first‐episode schizophrenia who are not old or very agitated and recommends first‐line treatment with aripiprazole, second‐ or third‐line treatment with risperidone/paliperidone or olanzapine, and fourth‐line treatment with clozapine. Long‐acting injection of the current antipsychotic agent can be used for poor medication adherence or based on patient preference. The agitation treatment algorithm recommends first‐line treatment with lorazepam and second‐ or third‐line treatment with quetiapine or levomepromazine and clearly instructs that the medication used for agitation should be reduced and then discontinued after remission of agitation. The maintenance treatment algorithm recommends the gradual reduction of antipsychotics to the minimum effective dose after remission of positive symptoms. Conclusions: We hope that our unique algorithms will be used broadly and will contribute to minimizing patients' burden related to antipsychotic treatment. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Human Psychopharmacology: Clinical & Experimental is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/hup.2804 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 1 Subjects: – SubjectFull: Drug therapy Type: general – SubjectFull: Aripiprazole Type: general – SubjectFull: Neuropsychopharmacology Type: general – SubjectFull: Patient compliance Type: general – SubjectFull: Patient preferences Type: general – SubjectFull: Schizophrenia Type: general Titles: – TitleFull: Pharmacological treatment algorithms for the acute phase, agitation, and maintenance phase of first‐episode schizophrenia: Japanese Society of Clinical Neuropsychopharmacology treatment algorithms. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Takeuchi, Hiroyoshi – PersonEntity: Name: NameFull: Takekita, Yoshiteru – PersonEntity: Name: NameFull: Hori, Hikaru – PersonEntity: Name: NameFull: Oya, Kazuto – PersonEntity: Name: NameFull: Miura, Itaru – PersonEntity: Name: NameFull: Hashimoto, Naoki – PersonEntity: Name: NameFull: Yasui‐Furukori, Norio IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 08856222 Numbering: – Type: volume Value: 36 – Type: issue Value: 6 Titles: – TitleFull: Human Psychopharmacology: Clinical & Experimental Type: main |
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