Standardised ginseng extract G115® potentiates the antidepressant-like properties of fluoxetine in the forced swim test.
Saved in:
| Title: | Standardised ginseng extract G115® potentiates the antidepressant-like properties of fluoxetine in the forced swim test. |
|---|---|
| Authors: | Terstege, Dylan J. (AUTHOR), MacDonald, Debra S. (AUTHOR), Tasker, R. Andrew (AUTHOR) |
| Source: | Acta Neuropsychiatrica. Jun2021, Vol. 33 Issue 3, p141-147. 7p. |
| Subjects: | Serotonin uptake inhibitors, Fluoxetine, Mental depression, Despair, Brain-derived neurotrophic factor, Ginseng |
| Abstract: | Objective: Ginsenosides, biologically active components of the root of Panax ginseng, have been reported to have therapeutic benefits in a number of disease states including psychiatric conditions such as major depressive disorder. Our objective was to determine if a standardised commercial ginseng extract, G115®, could reduce the signs of behavioural despair commonly observed in animal models of depression either alone or in combination with the selective serotonin reuptake inhibitor (SSRI) fluoxetine. Methods: Male Sprague-Dawley (SD) rats (N = 51) were divided into four groups: vehicle control, G115® ginseng root extract, fluoxetine and fluoxetine plus G115®. Rats were trained to voluntarily consume treatments twice daily for 14 days and were then tested in an open field (OF), elevated plus maze (EPM) and forced swim test (FST). Post-mortem hippocampal and prefrontal cortex tissue was analysed for expression of brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) by western blot. Results: One-way Analysis of Variance revealed no significant group differences in the OF or plus-maze performance on any variable examined. In the FST, fluoxetine significantly reduced immobility time and increased latency to immobility. The effects of fluoxetine were further significantly potentiated by co-administration of G115®. Post-mortem tissue analysis revealed significant group differences in BDNF expression in the left hippocampus and left prefrontal cortex without any accompanying changes in TrkB expression. Conclusions: We conclude that oral G115® significantly potentiates the antidepressant-like effect of fluoxetine in the FST in the absence of potentially confounding effects on locomotion and anxiety. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Neuropsychiatrica is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 153453894 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Standardised ginseng extract G115® potentiates the antidepressant-like properties of fluoxetine in the forced swim test. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Terstege%2C+Dylan+J%2E%22">Terstege, Dylan J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22MacDonald%2C+Debra+S%2E%22">MacDonald, Debra S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tasker%2C+R%2E+Andrew%22">Tasker, R. Andrew</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Neuropsychiatrica%22">Acta Neuropsychiatrica</searchLink>. Jun2021, Vol. 33 Issue 3, p141-147. 7p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Serotonin+uptake+inhibitors%22">Serotonin uptake inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22Fluoxetine%22">Fluoxetine</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Despair%22">Despair</searchLink><br /><searchLink fieldCode="DE" term="%22Brain-derived+neurotrophic+factor%22">Brain-derived neurotrophic factor</searchLink><br /><searchLink fieldCode="DE" term="%22Ginseng%22">Ginseng</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objective: Ginsenosides, biologically active components of the root of Panax ginseng, have been reported to have therapeutic benefits in a number of disease states including psychiatric conditions such as major depressive disorder. Our objective was to determine if a standardised commercial ginseng extract, G115®, could reduce the signs of behavioural despair commonly observed in animal models of depression either alone or in combination with the selective serotonin reuptake inhibitor (SSRI) fluoxetine. Methods: Male Sprague-Dawley (SD) rats (N = 51) were divided into four groups: vehicle control, G115® ginseng root extract, fluoxetine and fluoxetine plus G115®. Rats were trained to voluntarily consume treatments twice daily for 14 days and were then tested in an open field (OF), elevated plus maze (EPM) and forced swim test (FST). Post-mortem hippocampal and prefrontal cortex tissue was analysed for expression of brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) by western blot. Results: One-way Analysis of Variance revealed no significant group differences in the OF or plus-maze performance on any variable examined. In the FST, fluoxetine significantly reduced immobility time and increased latency to immobility. The effects of fluoxetine were further significantly potentiated by co-administration of G115®. Post-mortem tissue analysis revealed significant group differences in BDNF expression in the left hippocampus and left prefrontal cortex without any accompanying changes in TrkB expression. Conclusions: We conclude that oral G115® significantly potentiates the antidepressant-like effect of fluoxetine in the FST in the absence of potentially confounding effects on locomotion and anxiety. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Neuropsychiatrica is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=153453894 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1017/neu.2021.2 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 141 Subjects: – SubjectFull: Serotonin uptake inhibitors Type: general – SubjectFull: Fluoxetine Type: general – SubjectFull: Mental depression Type: general – SubjectFull: Despair Type: general – SubjectFull: Brain-derived neurotrophic factor Type: general – SubjectFull: Ginseng Type: general Titles: – TitleFull: Standardised ginseng extract G115® potentiates the antidepressant-like properties of fluoxetine in the forced swim test. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Terstege, Dylan J. – PersonEntity: Name: NameFull: MacDonald, Debra S. – PersonEntity: Name: NameFull: Tasker, R. Andrew IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 09242708 Numbering: – Type: volume Value: 33 – Type: issue Value: 3 Titles: – TitleFull: Acta Neuropsychiatrica Type: main |
| ResultId | 1 |
