View in EDS HTML Full Text PDF Full Text

Investigation of risk factors for the conversion of mild cognitive impairment to dementia.

Saved in:
Bibliographic Details
Title: Investigation of risk factors for the conversion of mild cognitive impairment to dementia.
Authors: Hu, Chengping (AUTHOR), Wang, Ling (AUTHOR), Zhao, Xudong (AUTHOR), Zhu, Binggen (AUTHOR), Tian, Ming (AUTHOR), Qin, Hongyun (AUTHOR)
Source: International Journal of Neuroscience. Dec 2021, Vol. 131 Issue 12, p1173-1180. 8p.
Subjects: Dementia, Mild cognitive impairment, Older people, Mental depression, Neuropsychological tests, Univariate analysis
Abstract: Mild cognitive impairment (MCI) is an intermediate state between normal aging and dementia and is characterized by pathological cognitive decline. The study aimed at revealing the risk of MCI progressing to dementia through a follow-up investigation. In 2011, 441 MCI subjects were recruited, and the disease status was tracked by the follow-up survey in 2017. Subjects with MCI stable (MCIs; N = 356) and MCI progressed into dementia (MCIp; N = 77) were analysed in our study. Community-dwelling old people of age ≥ 55 were recruited from 30 streets and 24 committees (or communities) of the Pudong New District (Shanghai, China). Neuropsychological tests of MMSE, MoCA, 17-item HAMD-17, ADL and HIS were performed. Additionally, the correlations of neuropsychological items and MCIp were explored by univariate and multivariate regression analyses. MCIp patients had the lower MMSE and MoCA total scores, whereas the ADL, and HIS total score in MCIp group were higher than in MCIs group. The univariate analysis revealed age, attention (MoCA), visuospatial/executive, number of births, marital status and attention and calculation were significant predictors of MCI progression. In multivariate analysis, age was an independent risk factor of MCI aggravating, while attention (MoCA) was independent protective factor for MCI progression. Age and worsening attention but not depression in MCI patients were independently associated with the progression of dementia in a 6-year follow-up period. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 153493741
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Investigation of risk factors for the conversion of mild cognitive impairment to dementia.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Hu%2C+Chengping%22">Hu, Chengping</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Ling%22">Wang, Ling</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhao%2C+Xudong%22">Zhao, Xudong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhu%2C+Binggen%22">Zhu, Binggen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tian%2C+Ming%22">Tian, Ming</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Qin%2C+Hongyun%22">Qin, Hongyun</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. Dec 2021, Vol. 131 Issue 12, p1173-1180. 8p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Dementia%22">Dementia</searchLink><br /><searchLink fieldCode="DE" term="%22Mild+cognitive+impairment%22">Mild cognitive impairment</searchLink><br /><searchLink fieldCode="DE" term="%22Older+people%22">Older people</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Neuropsychological+tests%22">Neuropsychological tests</searchLink><br /><searchLink fieldCode="DE" term="%22Univariate+analysis%22">Univariate analysis</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Mild cognitive impairment (MCI) is an intermediate state between normal aging and dementia and is characterized by pathological cognitive decline. The study aimed at revealing the risk of MCI progressing to dementia through a follow-up investigation. In 2011, 441 MCI subjects were recruited, and the disease status was tracked by the follow-up survey in 2017. Subjects with MCI stable (MCIs; N = 356) and MCI progressed into dementia (MCIp; N = 77) were analysed in our study. Community-dwelling old people of age ≥ 55 were recruited from 30 streets and 24 committees (or communities) of the Pudong New District (Shanghai, China). Neuropsychological tests of MMSE, MoCA, 17-item HAMD-17, ADL and HIS were performed. Additionally, the correlations of neuropsychological items and MCIp were explored by univariate and multivariate regression analyses. MCIp patients had the lower MMSE and MoCA total scores, whereas the ADL, and HIS total score in MCIp group were higher than in MCIs group. The univariate analysis revealed age, attention (MoCA), visuospatial/executive, number of births, marital status and attention and calculation were significant predictors of MCI progression. In multivariate analysis, age was an independent risk factor of MCI aggravating, while attention (MoCA) was independent protective factor for MCI progression. Age and worsening attention but not depression in MCI patients were independently associated with the progression of dementia in a 6-year follow-up period. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=153493741
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/00207454.2020.1782905
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 1173
    Subjects:
      – SubjectFull: Dementia
        Type: general
      – SubjectFull: Mild cognitive impairment
        Type: general
      – SubjectFull: Older people
        Type: general
      – SubjectFull: Mental depression
        Type: general
      – SubjectFull: Neuropsychological tests
        Type: general
      – SubjectFull: Univariate analysis
        Type: general
    Titles:
      – TitleFull: Investigation of risk factors for the conversion of mild cognitive impairment to dementia.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Hu, Chengping
      – PersonEntity:
          Name:
            NameFull: Wang, Ling
      – PersonEntity:
          Name:
            NameFull: Zhao, Xudong
      – PersonEntity:
          Name:
            NameFull: Zhu, Binggen
      – PersonEntity:
          Name:
            NameFull: Tian, Ming
      – PersonEntity:
          Name:
            NameFull: Qin, Hongyun
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 12
              Text: Dec 2021
              Type: published
              Y: 2021
          Identifiers:
            – Type: issn-print
              Value: 00207454
          Numbering:
            – Type: volume
              Value: 131
            – Type: issue
              Value: 12
          Titles:
            – TitleFull: International Journal of Neuroscience
              Type: main
ResultId 1