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The Box Task: A novel tool to differentiate the primary progressive aphasias.

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Title: The Box Task: A novel tool to differentiate the primary progressive aphasias.
Authors: Foxe, David (AUTHOR), Irish, Muireann (AUTHOR), D'Mello, Mirelle (AUTHOR), Barhon, Lucienne (AUTHOR), Burrell, James R. (AUTHOR), Kessels, Roy P.C. (AUTHOR), Piguet, Olivier (AUTHOR)
Source: European Journal of Neurology. Dec2021, Vol. 28 Issue 12, p3945-3954. 10p.
Subjects: Aphasia, Agrammatism, Short-term memory, Logistic regression analysis, Alzheimer's disease, Memory testing
Abstract: Objective: Differentiating the primary progressive aphasia (PPA) variants in clinical settings remains complex and challenging, especially for the logopenic (lv‐PPA) and non‐fluent variants (nfv‐PPA). Recent studies suggest that visuospatial memory is more compromised in lv‐PPA than in nfv‐PPA and is relatively spared in the semantic variant (sv‐PPA). Accordingly, assessment of visuospatial memory performance may assist in the differential diagnosis of PPA variants. Here, we investigated the utility of a novel computerised visuospatial working memory test—the Box Task—to differentiate the three PPA variants and typical Alzheimer's disease (AD). Methods: Eighteen lv‐PPA, 14 nfv‐PPA, 23 sv‐PPA, 33 AD patients, and 32 healthy controls matched for age and education were recruited. All participants completed the computerised Box Task and WMS‐III Spatial Span as measures of visuospatial working memory. Results: The lv‐PPA group made significantly more Box Task between‐search errors than nfv‐PPA, sv‐PPA and control groups. The AD group, however, displayed the greatest impairments on this measure relative to the PPA variants. Logistic regression analyses in lv‐PPA and nfv‐PPA demonstrated that the combination of Box Task between‐search error variables (i.e., 4‐ and 6‐box levels) could correctly classify 72% of lv‐PPA patients and nearly 79% of nfv‐PPA patients. Area under the receiver operator characteristics curve (AUC) analyses revealed the Box Task was more sensitive than Spatial Span at differentiating lv‐PPA from nfv‐PPA. Conclusions: Our findings suggest that a simple, computerised measure of visuospatial working memory—the Box Task—shows potential diagnostic utility in differentiating lv‐PPA from the other PPA variants. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: The Box Task: A novel tool to differentiate the primary progressive aphasias.
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  Data: <searchLink fieldCode="AR" term="%22Foxe%2C+David%22">Foxe, David</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Irish%2C+Muireann%22">Irish, Muireann</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22D'Mello%2C+Mirelle%22">D'Mello, Mirelle</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Barhon%2C+Lucienne%22">Barhon, Lucienne</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Burrell%2C+James+R%2E%22">Burrell, James R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kessels%2C+Roy+P%2EC%2E%22">Kessels, Roy P.C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Piguet%2C+Olivier%22">Piguet, Olivier</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Dec2021, Vol. 28 Issue 12, p3945-3954. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Aphasia%22">Aphasia</searchLink><br /><searchLink fieldCode="DE" term="%22Agrammatism%22">Agrammatism</searchLink><br /><searchLink fieldCode="DE" term="%22Short-term+memory%22">Short-term memory</searchLink><br /><searchLink fieldCode="DE" term="%22Logistic+regression+analysis%22">Logistic regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+disease%22">Alzheimer's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Memory+testing%22">Memory testing</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Objective: Differentiating the primary progressive aphasia (PPA) variants in clinical settings remains complex and challenging, especially for the logopenic (lv‐PPA) and non‐fluent variants (nfv‐PPA). Recent studies suggest that visuospatial memory is more compromised in lv‐PPA than in nfv‐PPA and is relatively spared in the semantic variant (sv‐PPA). Accordingly, assessment of visuospatial memory performance may assist in the differential diagnosis of PPA variants. Here, we investigated the utility of a novel computerised visuospatial working memory test—the Box Task—to differentiate the three PPA variants and typical Alzheimer's disease (AD). Methods: Eighteen lv‐PPA, 14 nfv‐PPA, 23 sv‐PPA, 33 AD patients, and 32 healthy controls matched for age and education were recruited. All participants completed the computerised Box Task and WMS‐III Spatial Span as measures of visuospatial working memory. Results: The lv‐PPA group made significantly more Box Task between‐search errors than nfv‐PPA, sv‐PPA and control groups. The AD group, however, displayed the greatest impairments on this measure relative to the PPA variants. Logistic regression analyses in lv‐PPA and nfv‐PPA demonstrated that the combination of Box Task between‐search error variables (i.e., 4‐ and 6‐box levels) could correctly classify 72% of lv‐PPA patients and nearly 79% of nfv‐PPA patients. Area under the receiver operator characteristics curve (AUC) analyses revealed the Box Task was more sensitive than Spatial Span at differentiating lv‐PPA from nfv‐PPA. Conclusions: Our findings suggest that a simple, computerised measure of visuospatial working memory—the Box Task—shows potential diagnostic utility in differentiating lv‐PPA from the other PPA variants. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – TitleFull: The Box Task: A novel tool to differentiate the primary progressive aphasias.
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              Text: Dec2021
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