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Functional connectivity and cognitive changes after donepezil treatment in healthy participants.

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Title: Functional connectivity and cognitive changes after donepezil treatment in healthy participants.
Authors: Péran, P. (AUTHOR), Salabert, A.S. (AUTHOR), Dondaine, T. (AUTHOR), Leclerc, X. (AUTHOR), Gros-Dagnac, H. (AUTHOR), Ranjeva, J.-P. (AUTHOR), Lopes, R. (AUTHOR), Lanteaume, L. (AUTHOR), Blin, O. (AUTHOR), Thalamas, C. (AUTHOR), Bordet, R. (AUTHOR), Payoux, P. (AUTHOR)
Source: Psychopharmacology. Nov2021, Vol. 238 Issue 11, p3071-3082. 12p. 2 Color Photographs, 1 Illustration, 1 Diagram, 4 Charts.
Subjects: Functional connectivity, Donepezil, Acetylcholinesterase inhibitors, Young adults, Adults, Pharmacodynamics
Abstract: Rationale: Donepezil is a potent, noncompetitive, reversible, clinically effective acetylcholinesterase inhibitor. The effects of this drug on healthy brains have seldom been investigated. Objectives: The primary objective of the present study was to identify possible functional connectivity markers of the effect of donepezil in healthy young adult volunteers. Methods: The study had a double-blind, randomized, crossover design. 30 healthy adult volunteers underwent resting-state MRI scans during 15 days of donepezil or placebo treatment, in accordance with the design. Results: Results showed significant differences in intrinsic functional connectivity between donepezil and placebo, mainly in the right executive control network (RECN). More specifically, we found a decrease in the connectivity of the right inferior parietal node with other RECN nodes. Analysis using the cingulate cortex and parahippocampal regions as seeds also revealed complex modulation of functional connectivity in the donepezil condition. Conclusions: In conclusion, donepezil treatment for 15 days may result in reorganization of resting-state networks, compared with placebo. [ABSTRACT FROM AUTHOR]
Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Functional connectivity and cognitive changes after donepezil treatment in healthy participants.
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  Data: <searchLink fieldCode="AR" term="%22Péran%2C+P%2E%22">Péran, P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Salabert%2C+A%2ES%2E%22">Salabert, A.S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dondaine%2C+T%2E%22">Dondaine, T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Leclerc%2C+X%2E%22">Leclerc, X.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gros-Dagnac%2C+H%2E%22">Gros-Dagnac, H.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ranjeva%2C+J%2E-P%2E%22">Ranjeva, J.-P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lopes%2C+R%2E%22">Lopes, R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lanteaume%2C+L%2E%22">Lanteaume, L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Blin%2C+O%2E%22">Blin, O.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Thalamas%2C+C%2E%22">Thalamas, C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bordet%2C+R%2E%22">Bordet, R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Payoux%2C+P%2E%22">Payoux, P.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Nov2021, Vol. 238 Issue 11, p3071-3082. 12p. 2 Color Photographs, 1 Illustration, 1 Diagram, 4 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Functional+connectivity%22">Functional connectivity</searchLink><br /><searchLink fieldCode="DE" term="%22Donepezil%22">Donepezil</searchLink><br /><searchLink fieldCode="DE" term="%22Acetylcholinesterase+inhibitors%22">Acetylcholinesterase inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22Young+adults%22">Young adults</searchLink><br /><searchLink fieldCode="DE" term="%22Adults%22">Adults</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmacodynamics%22">Pharmacodynamics</searchLink>
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  Data: Rationale: Donepezil is a potent, noncompetitive, reversible, clinically effective acetylcholinesterase inhibitor. The effects of this drug on healthy brains have seldom been investigated. Objectives: The primary objective of the present study was to identify possible functional connectivity markers of the effect of donepezil in healthy young adult volunteers. Methods: The study had a double-blind, randomized, crossover design. 30 healthy adult volunteers underwent resting-state MRI scans during 15 days of donepezil or placebo treatment, in accordance with the design. Results: Results showed significant differences in intrinsic functional connectivity between donepezil and placebo, mainly in the right executive control network (RECN). More specifically, we found a decrease in the connectivity of the right inferior parietal node with other RECN nodes. Analysis using the cingulate cortex and parahippocampal regions as seeds also revealed complex modulation of functional connectivity in the donepezil condition. Conclusions: In conclusion, donepezil treatment for 15 days may result in reorganization of resting-state networks, compared with placebo. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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