Effects of topiramate on the association between affect, cannabis craving, and cannabis use in the daily life of youth during a randomized clinical trial.
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| Title: | Effects of topiramate on the association between affect, cannabis craving, and cannabis use in the daily life of youth during a randomized clinical trial. |
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| Authors: | Emery, Noah N. (AUTHOR), Carpenter, Ryan W. (AUTHOR), Meisel, Samuel N. (AUTHOR), Miranda Jr, Robert (AUTHOR) |
| Source: | Psychopharmacology. Nov2021, Vol. 238 Issue 11, p3095-3106. 12p. 3 Charts, 2 Graphs. |
| Subjects: | Affect (Psychology), Clinical trials, Ecological momentary assessments (Clinical psychology), Desire, Marijuana, Weed competition, Synthetic marijuana |
| Abstract: | Rationale: Topiramate is an anticonvulsant currently under study for treating substance use disorders. Topiramate is thought to reduce substance use by attenuating craving and the rewarding effects of acute substance use through its concurrent GABAergic agonism and glutamatergic antagonism. Importantly, topiramate also impacts mood states central to many models of substance use. Despite this, little previous research has examined whether topiramate attenuates the respective associations of affect and craving with substance use. Objectives: We conducted a secondary analysis of 63 youths that exhibited heavy cannabis use, aged 15–24 years, who were randomized in a double-blinded 6-week clinical trial comparing the effects of topiramate (up to 200 mg/day) and placebo on cannabis use. Ecological momentary assessment data were leveraged to model the role positive affect, negative affect, and craving on use over the 6-week period and whether topiramate attenuated associations between these feeling states and cannabis use. Results: Findings showed that craving was positively associated with use at the within-person level, while positive affect was negatively associated with use at the between-person level. Topiramate appears to attenuate the negative association of between-person positive affect (i.e., average) and cannabis use. Specifically, those in the placebo condition exhibited this inverse association between average positive affect and use while those in topiramate condition did not. No other significant affect or affect × medication condition interactions were observed. Conclusions: These findings implicate craving and low positive affect as important risk factors for cannabis use in youth in treatment. Topiramate may attenuate this association for positive affect. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 153682955 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Effects of topiramate on the association between affect, cannabis craving, and cannabis use in the daily life of youth during a randomized clinical trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Emery%2C+Noah+N%2E%22">Emery, Noah N.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Carpenter%2C+Ryan+W%2E%22">Carpenter, Ryan W.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Meisel%2C+Samuel+N%2E%22">Meisel, Samuel N.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Miranda+Jr%2C+Robert%22">Miranda Jr, Robert</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Nov2021, Vol. 238 Issue 11, p3095-3106. 12p. 3 Charts, 2 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Affect+%28Psychology%29%22">Affect (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+trials%22">Clinical trials</searchLink><br /><searchLink fieldCode="DE" term="%22Ecological+momentary+assessments+%28Clinical+psychology%29%22">Ecological momentary assessments (Clinical psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Desire%22">Desire</searchLink><br /><searchLink fieldCode="DE" term="%22Marijuana%22">Marijuana</searchLink><br /><searchLink fieldCode="DE" term="%22Weed+competition%22">Weed competition</searchLink><br /><searchLink fieldCode="DE" term="%22Synthetic+marijuana%22">Synthetic marijuana</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Rationale: Topiramate is an anticonvulsant currently under study for treating substance use disorders. Topiramate is thought to reduce substance use by attenuating craving and the rewarding effects of acute substance use through its concurrent GABAergic agonism and glutamatergic antagonism. Importantly, topiramate also impacts mood states central to many models of substance use. Despite this, little previous research has examined whether topiramate attenuates the respective associations of affect and craving with substance use. Objectives: We conducted a secondary analysis of 63 youths that exhibited heavy cannabis use, aged 15–24 years, who were randomized in a double-blinded 6-week clinical trial comparing the effects of topiramate (up to 200 mg/day) and placebo on cannabis use. Ecological momentary assessment data were leveraged to model the role positive affect, negative affect, and craving on use over the 6-week period and whether topiramate attenuated associations between these feeling states and cannabis use. Results: Findings showed that craving was positively associated with use at the within-person level, while positive affect was negatively associated with use at the between-person level. Topiramate appears to attenuate the negative association of between-person positive affect (i.e., average) and cannabis use. Specifically, those in the placebo condition exhibited this inverse association between average positive affect and use while those in topiramate condition did not. No other significant affect or affect × medication condition interactions were observed. Conclusions: These findings implicate craving and low positive affect as important risk factors for cannabis use in youth in treatment. Topiramate may attenuate this association for positive affect. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00213-021-05925-5 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 3095 Subjects: – SubjectFull: Affect (Psychology) Type: general – SubjectFull: Clinical trials Type: general – SubjectFull: Ecological momentary assessments (Clinical psychology) Type: general – SubjectFull: Desire Type: general – SubjectFull: Marijuana Type: general – SubjectFull: Weed competition Type: general – SubjectFull: Synthetic marijuana Type: general Titles: – TitleFull: Effects of topiramate on the association between affect, cannabis craving, and cannabis use in the daily life of youth during a randomized clinical trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Emery, Noah N. – PersonEntity: Name: NameFull: Carpenter, Ryan W. – PersonEntity: Name: NameFull: Meisel, Samuel N. – PersonEntity: Name: NameFull: Miranda Jr, Robert IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 238 – Type: issue Value: 11 Titles: – TitleFull: Psychopharmacology Type: main |
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