Incidental evidence of hypointensity in brain grey nuclei on routine MR imaging: when to suspect a neurodegenerative disorder?
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| Title: | Incidental evidence of hypointensity in brain grey nuclei on routine MR imaging: when to suspect a neurodegenerative disorder? |
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| Authors: | Morelli, Maurizio (AUTHOR), Quattrone, Andrea (AUTHOR), Arabia, Gennarina (AUTHOR), Vescio, Basilio (AUTHOR), Vaccaro, Maria Grazia (AUTHOR), Mechelli, Alessandro (AUTHOR), Rocca, Federico (AUTHOR), Gambardella, Antonio (AUTHOR), Quattrone, Aldo (AUTHOR) |
| Source: | Neurological Sciences. Jan2022, Vol. 43 Issue 1, p643-650. 8p. 1 Black and White Photograph, 3 Charts, 1 Graph. |
| Abstract: | Deep grey nuclei of the human brain accumulate minerals both in aging and in several neurodegenerative diseases. Mineral deposition produces a shortening of the transverse relaxation time which causes hypointensity on magnetic resonance (MR) imaging. The physician often has difficulties in determining whether the incidental hypointensity of grey nuclei seen on MR images is related to aging or neurodegenerative pathology. We investigated the hypointensity patterns in globus pallidus, putamen, caudate nucleus, thalamus and dentate nucleus of 217 healthy subjects (ages, 20-79 years; men/women, 104/113) using 3T MR imaging. Hypointensity was detected more frequently in globus pallidus (35.5%) than in dentate nucleus (32.7%) and putamen (7.8%). A consistent effect of aging on hypointensity (p < 0.001) of these grey nuclei was evident. Putaminal hypointensity appeared only in elderly subjects whereas we did not find hypointensity in the caudate nucleus and thalamus of any subject. In conclusion, the evidence of hypointensity in the caudate nucleus and thalamus at any age or hypointensity in the putamen seen in young subjects should prompt the clinician to consider a neurodegenerative disease. [ABSTRACT FROM AUTHOR] |
| Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 154457524 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Incidental evidence of hypointensity in brain grey nuclei on routine MR imaging: when to suspect a neurodegenerative disorder? – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Morelli%2C+Maurizio%22">Morelli, Maurizio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Quattrone%2C+Andrea%22">Quattrone, Andrea</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Arabia%2C+Gennarina%22">Arabia, Gennarina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vescio%2C+Basilio%22">Vescio, Basilio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vaccaro%2C+Maria+Grazia%22">Vaccaro, Maria Grazia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mechelli%2C+Alessandro%22">Mechelli, Alessandro</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rocca%2C+Federico%22">Rocca, Federico</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gambardella%2C+Antonio%22">Gambardella, Antonio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Quattrone%2C+Aldo%22">Quattrone, Aldo</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Jan2022, Vol. 43 Issue 1, p643-650. 8p. 1 Black and White Photograph, 3 Charts, 1 Graph. – Name: Abstract Label: Abstract Group: Ab Data: Deep grey nuclei of the human brain accumulate minerals both in aging and in several neurodegenerative diseases. Mineral deposition produces a shortening of the transverse relaxation time which causes hypointensity on magnetic resonance (MR) imaging. The physician often has difficulties in determining whether the incidental hypointensity of grey nuclei seen on MR images is related to aging or neurodegenerative pathology. We investigated the hypointensity patterns in globus pallidus, putamen, caudate nucleus, thalamus and dentate nucleus of 217 healthy subjects (ages, 20-79 years; men/women, 104/113) using 3T MR imaging. Hypointensity was detected more frequently in globus pallidus (35.5%) than in dentate nucleus (32.7%) and putamen (7.8%). A consistent effect of aging on hypointensity (p < 0.001) of these grey nuclei was evident. Putaminal hypointensity appeared only in elderly subjects whereas we did not find hypointensity in the caudate nucleus and thalamus of any subject. In conclusion, the evidence of hypointensity in the caudate nucleus and thalamus at any age or hypointensity in the putamen seen in young subjects should prompt the clinician to consider a neurodegenerative disease. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10072-021-05292-1 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 643 Titles: – TitleFull: Incidental evidence of hypointensity in brain grey nuclei on routine MR imaging: when to suspect a neurodegenerative disorder? Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Morelli, Maurizio – PersonEntity: Name: NameFull: Quattrone, Andrea – PersonEntity: Name: NameFull: Arabia, Gennarina – PersonEntity: Name: NameFull: Vescio, Basilio – PersonEntity: Name: NameFull: Vaccaro, Maria Grazia – PersonEntity: Name: NameFull: Mechelli, Alessandro – PersonEntity: Name: NameFull: Rocca, Federico – PersonEntity: Name: NameFull: Gambardella, Antonio – PersonEntity: Name: NameFull: Quattrone, Aldo IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 15901874 Numbering: – Type: volume Value: 43 – Type: issue Value: 1 Titles: – TitleFull: Neurological Sciences Type: main |
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