Effects of lithium use on the white matter of patients with bipolar disorder – a systematic review.
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| Title: | Effects of lithium use on the white matter of patients with bipolar disorder – a systematic review. |
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| Authors: | Espanhol, José Carlos L. (AUTHOR), Vieira-Coelho, Maria A. (AUTHOR) |
| Source: | Nordic Journal of Psychiatry. Jan 2022, Vol. 76 Issue 1, p1-11. 11p. |
| Subjects: | White matter (Nerve tissue), Bipolar disorder, Diffusion tensor imaging, Therapeutic use of lithium, Lithium carbonate |
| Abstract: | Several studies revealed changes in the microstructure of white matter in bipolar disorder patients. Lithium has been reported as having neuroprotective effects. However, its effect on the white matter remains unclear. This systematic review aims to identify the existing clinical evidence of lithium's effect on the white matter from bipolar disorder patients. PRISMA guidelines were followed for a systematic literature review to assess the effect of lithium on the white matter of patients with bipolar disorder. From a total of 204 studies screened, 16 were included in the final systematic review. The quality assessment of the included records was assessed by the Newcastle–Ottawa scale. Most studies included (13 out of 16) evaluated diffusion tensor imaging measures to assess white matter integrity. Of these, eleven reported a positive effect of lithium on the integrity of white matter of bipolar disorder patients. Two reported no effect. Two studies evaluated white matter volume. The first reported that lithium attenuates the reduction of white matter volume over time, and the second reported significantly smaller white matter volume in non-lithium-using patients. The last evaluated ventricular brain ratio and reported that patients treated with lithium did not have a significantly greater ventricular size than their normal control counterparts. Lithium appears to positively influence the evolution of the white matter abnormalities described in bipolar disorder patients. Should this information be confirmed in future research, and given its important mood stabilizer effect, it could further reinforce the use of lithium in the treatment of bipolar disorder. [ABSTRACT FROM AUTHOR] |
| Copyright of Nordic Journal of Psychiatry is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 154479346 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Effects of lithium use on the white matter of patients with bipolar disorder – a systematic review. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Espanhol%2C+José+Carlos+L%2E%22">Espanhol, José Carlos L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vieira-Coelho%2C+Maria+A%2E%22">Vieira-Coelho, Maria A.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nordic+Journal+of+Psychiatry%22">Nordic Journal of Psychiatry</searchLink>. Jan 2022, Vol. 76 Issue 1, p1-11. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22White+matter+%28Nerve+tissue%29%22">White matter (Nerve tissue)</searchLink><br /><searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Diffusion+tensor+imaging%22">Diffusion tensor imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutic+use+of+lithium%22">Therapeutic use of lithium</searchLink><br /><searchLink fieldCode="DE" term="%22Lithium+carbonate%22">Lithium carbonate</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Several studies revealed changes in the microstructure of white matter in bipolar disorder patients. Lithium has been reported as having neuroprotective effects. However, its effect on the white matter remains unclear. This systematic review aims to identify the existing clinical evidence of lithium's effect on the white matter from bipolar disorder patients. PRISMA guidelines were followed for a systematic literature review to assess the effect of lithium on the white matter of patients with bipolar disorder. From a total of 204 studies screened, 16 were included in the final systematic review. The quality assessment of the included records was assessed by the Newcastle–Ottawa scale. Most studies included (13 out of 16) evaluated diffusion tensor imaging measures to assess white matter integrity. Of these, eleven reported a positive effect of lithium on the integrity of white matter of bipolar disorder patients. Two reported no effect. Two studies evaluated white matter volume. The first reported that lithium attenuates the reduction of white matter volume over time, and the second reported significantly smaller white matter volume in non-lithium-using patients. The last evaluated ventricular brain ratio and reported that patients treated with lithium did not have a significantly greater ventricular size than their normal control counterparts. Lithium appears to positively influence the evolution of the white matter abnormalities described in bipolar disorder patients. Should this information be confirmed in future research, and given its important mood stabilizer effect, it could further reinforce the use of lithium in the treatment of bipolar disorder. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nordic Journal of Psychiatry is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=154479346 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/08039488.2021.1921264 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 1 Subjects: – SubjectFull: White matter (Nerve tissue) Type: general – SubjectFull: Bipolar disorder Type: general – SubjectFull: Diffusion tensor imaging Type: general – SubjectFull: Therapeutic use of lithium Type: general – SubjectFull: Lithium carbonate Type: general Titles: – TitleFull: Effects of lithium use on the white matter of patients with bipolar disorder – a systematic review. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Espanhol, José Carlos L. – PersonEntity: Name: NameFull: Vieira-Coelho, Maria A. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan 2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 08039488 Numbering: – Type: volume Value: 76 – Type: issue Value: 1 Titles: – TitleFull: Nordic Journal of Psychiatry Type: main |
| ResultId | 1 |
