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Cancer risk in patients with migraine: A population‐based cohort study in Denmark.

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Title: Cancer risk in patients with migraine: A population‐based cohort study in Denmark.
Authors: Elser, Holly, Skajaa, Nils, Ehrenstein, Vera, Fuglsang, Cecilia Hvitfeldt, Farkas, Dóra Körmendiné, Sørensen, Henrik Toft
Source: Headache: The Journal of Head & Face Pain. Jan2022, Vol. 62 Issue 1, p57-64. 8p.
Subjects: Tumor risk factors, Migraine diagnosis, Reporting of diseases, Confidence intervals, Guttman scale, Comparative studies, Population health, Longitudinal method
Geographic Terms: Denmark
Abstract: Objective: The purpose of this study was to examine overall and site‐specific cancer risk among individuals diagnosed with migraine compared with the general population. Background: Current evidence regarding migraine and risk of cancer is sparse and inconclusive. Methods: We conducted a nationwide population‐based cohort study with data collected routinely and prospectively from Danish population‐based registries from 1995 to 2017. We computed the age‐ and sex‐standardized incidence ratio (SIR) as the ratio of observed to expected cancers among patients diagnosed with migraine in the study population overall, and by encounter type of first diagnosis (inpatient, outpatient specialty clinic, and emergency department). Site‐specific cancers were grouped according to etiology. Results: We identified 72,826 patients with a first‐time hospital migraine diagnosis. There were 3090 observed overall cancer cases among individuals diagnosed with migraine as compared with 3108 expected cases (SIR 0.99, 95% confidence interval [CI]: 0.96–1.03). The cumulative incidence of all cancers combined from 1995 to 2017 among those with a first‐time migraine diagnosis was 9.47% (95% CI: 9.08–9.87). The SIRs for most cancers were consistent with absence of an association: 1.00 (95% CI: 0.94–1.06) for hormone‐related cancers, 0.96 (95% CI: 0.88–1.03) for smoking‐related cancers, 1.10 (95% CI: 0.98–1.24) for hematologic cancers, and 0.95 (95% CI: 0.85–1.06) for immune‐related cancers. Exceptions were SIRs for gastrointestinal cancers (0.78, 95% CI: 0.70–0.87) and for cancers of neurological origin (1.57, 95% CI: 1.40–1.76). Conclusions: For most cancer groups, our results did not support an association with migraine. The exceptions were an increased risk for cancers of neurological origin and a decreased risk for gastrointestinal cancers. These findings may reflect a true difference in risk among individuals with migraine, or more plausibly they reflect other forces, such as differences in medication use, detection bias and reverse causation, or shared risk factors. [ABSTRACT FROM AUTHOR]
Copyright of Headache: The Journal of Head & Face Pain is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Cancer risk in patients with migraine: A population‐based cohort study in Denmark.
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  Data: <searchLink fieldCode="AR" term="%22Elser%2C+Holly%22">Elser, Holly</searchLink><br /><searchLink fieldCode="AR" term="%22Skajaa%2C+Nils%22">Skajaa, Nils</searchLink><br /><searchLink fieldCode="AR" term="%22Ehrenstein%2C+Vera%22">Ehrenstein, Vera</searchLink><br /><searchLink fieldCode="AR" term="%22Fuglsang%2C+Cecilia Hvitfeldt%22">Fuglsang, Cecilia Hvitfeldt</searchLink><br /><searchLink fieldCode="AR" term="%22Farkas%2C+Dóra+Körmendiné%22">Farkas, Dóra Körmendiné</searchLink><br /><searchLink fieldCode="AR" term="%22Sørensen%2C+Henrik Toft%22">Sørensen, Henrik Toft</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Headache%3A+The+Journal+of+Head+%26+Face+Pain%22">Headache: The Journal of Head & Face Pain</searchLink>. Jan2022, Vol. 62 Issue 1, p57-64. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Tumor+risk+factors%22">Tumor risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Migraine+diagnosis%22">Migraine diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Reporting+of+diseases%22">Reporting of diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Guttman+scale%22">Guttman scale</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Population+health%22">Population health</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink>
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  Label: Geographic Terms
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  Data: <searchLink fieldCode="DE" term="%22Denmark%22">Denmark</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: The purpose of this study was to examine overall and site‐specific cancer risk among individuals diagnosed with migraine compared with the general population. Background: Current evidence regarding migraine and risk of cancer is sparse and inconclusive. Methods: We conducted a nationwide population‐based cohort study with data collected routinely and prospectively from Danish population‐based registries from 1995 to 2017. We computed the age‐ and sex‐standardized incidence ratio (SIR) as the ratio of observed to expected cancers among patients diagnosed with migraine in the study population overall, and by encounter type of first diagnosis (inpatient, outpatient specialty clinic, and emergency department). Site‐specific cancers were grouped according to etiology. Results: We identified 72,826 patients with a first‐time hospital migraine diagnosis. There were 3090 observed overall cancer cases among individuals diagnosed with migraine as compared with 3108 expected cases (SIR 0.99, 95% confidence interval [CI]: 0.96–1.03). The cumulative incidence of all cancers combined from 1995 to 2017 among those with a first‐time migraine diagnosis was 9.47% (95% CI: 9.08–9.87). The SIRs for most cancers were consistent with absence of an association: 1.00 (95% CI: 0.94–1.06) for hormone‐related cancers, 0.96 (95% CI: 0.88–1.03) for smoking‐related cancers, 1.10 (95% CI: 0.98–1.24) for hematologic cancers, and 0.95 (95% CI: 0.85–1.06) for immune‐related cancers. Exceptions were SIRs for gastrointestinal cancers (0.78, 95% CI: 0.70–0.87) and for cancers of neurological origin (1.57, 95% CI: 1.40–1.76). Conclusions: For most cancer groups, our results did not support an association with migraine. The exceptions were an increased risk for cancers of neurological origin and a decreased risk for gastrointestinal cancers. These findings may reflect a true difference in risk among individuals with migraine, or more plausibly they reflect other forces, such as differences in medication use, detection bias and reverse causation, or shared risk factors. [ABSTRACT FROM AUTHOR]
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  Label:
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  Data: <i>Copyright of Headache: The Journal of Head & Face Pain is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1111/head.14251
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 57
    Subjects:
      – SubjectFull: Tumor risk factors
        Type: general
      – SubjectFull: Migraine diagnosis
        Type: general
      – SubjectFull: Reporting of diseases
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Guttman scale
        Type: general
      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Population health
        Type: general
      – SubjectFull: Longitudinal method
        Type: general
      – SubjectFull: Denmark
        Type: general
    Titles:
      – TitleFull: Cancer risk in patients with migraine: A population‐based cohort study in Denmark.
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            NameFull: Elser, Holly
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            NameFull: Skajaa, Nils
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            NameFull: Ehrenstein, Vera
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            NameFull: Fuglsang, Cecilia Hvitfeldt
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            NameFull: Farkas, Dóra Körmendiné
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            NameFull: Sørensen, Henrik Toft
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            – D: 01
              M: 01
              Text: Jan2022
              Type: published
              Y: 2022
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              Value: 00178748
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              Value: 62
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            – TitleFull: Headache: The Journal of Head & Face Pain
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