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Suicidality and self‐injury with selective serotonin reuptake inhibitors in youth: Occurrence, predictors and timing.

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Title: Suicidality and self‐injury with selective serotonin reuptake inhibitors in youth: Occurrence, predictors and timing.
Authors: Sørensen, Johanne Østerby (AUTHOR), Rasmussen, Annette (AUTHOR), Roesbjerg, Troels (AUTHOR), Verhulst, Frank C. (AUTHOR), Pagsberg, Anne Katrine (AUTHOR)
Source: Acta Psychiatrica Scandinavica. Feb2022, Vol. 145 Issue 2, p209-222. 14p. 4 Charts, 1 Graph.
Subjects: Serotonin uptake inhibitors, Suicidal ideation, Attempted suicide, At-risk youth, Obsessive-compulsive disorder, Self-injurious behavior
Abstract: Objective: Meta‐analyses have established a heightened risk of suicidality for youth treated with selective serotonin reuptake inhibitors (SSRIs). The present study investigates the risk and possible predictors of suicidality and non‐suicidal self‐injury (NSSI) associated with SSRI treatment in a clinical sample of children and adolescents. Methods: An observational, longitudinal, retrospective study using a within‐subject study design including in‐ and outpatients aged 0–17 years treated with SSRIs. Data were obtained from digital medical records and prescription software. Results: N = 365 patients were included (64.1% female), mean (SD) age 14.5 (2.04) years, with primary depression, anxiety or obsessive‐compulsive disorder. No suicides occurred. When comparing the 6‐week period immediately prior to versus following SSRI initiation, the patient proportion with broadly defined suicidality decreased (38.5% vs. 24.2%, p < 0.001) while the proportion with suicide attempts was stable (2.8% vs. 2.8%, p = 1.000). The proportion with NSSI decreased statistically non‐significantly (12.4% vs. 8.4%, p = 0.067). Results from individually standardized observation periods were similar; however, the proportion with suicide attempts decreased statistically non‐significantly and the proportion with NSSI decreased significantly. Suicidality during SSRI treatment was associated with previous suicidality (OR[CI] = 6.0 [2.4–14.8], p < 0.001), depression as indication for SSRI treatment (OR[CI] = 2.1 [1.2–3.7], p = 0.01), female sex (OR[CI] = 2.1 [1.1–4.1], p = 0.02) and previous NSSI (OR[CI] = 2.0 [1.2–3.5], p = 0.01). Conclusion: Suicidality was common in youth treated with SSRIs. The patient proportion with overall suicidality decreased, and the proportion with attempted suicide was stable in the weeks following SSRI initiation. Previous suicidality, depression, female sex and previous NSSI are important predictors for suicidality during SSRI treatment in youth. [ABSTRACT FROM AUTHOR]
Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Suicidality and self‐injury with selective serotonin reuptake inhibitors in youth: Occurrence, predictors and timing.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22S&#248;rensen%2C+Johanne+&#216;sterby%22&quot;&gt;S&#248;rensen, Johanne &#216;sterby&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rasmussen%2C+Annette%22&quot;&gt;Rasmussen, Annette&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Roesbjerg%2C+Troels%22&quot;&gt;Roesbjerg, Troels&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Verhulst%2C+Frank+C%2E%22&quot;&gt;Verhulst, Frank C.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Pagsberg%2C+Anne+Katrine%22&quot;&gt;Pagsberg, Anne Katrine&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Acta+Psychiatrica+Scandinavica%22&quot;&gt;Acta Psychiatrica Scandinavica&lt;/searchLink&gt;. Feb2022, Vol. 145 Issue 2, p209-222. 14p. 4 Charts, 1 Graph.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Serotonin+uptake+inhibitors%22&quot;&gt;Serotonin uptake inhibitors&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Suicidal+ideation%22&quot;&gt;Suicidal ideation&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Attempted+suicide%22&quot;&gt;Attempted suicide&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22At-risk+youth%22&quot;&gt;At-risk youth&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Obsessive-compulsive+disorder%22&quot;&gt;Obsessive-compulsive disorder&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Self-injurious+behavior%22&quot;&gt;Self-injurious behavior&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: Meta‐analyses have established a heightened risk of suicidality for youth treated with selective serotonin reuptake inhibitors (SSRIs). The present study investigates the risk and possible predictors of suicidality and non‐suicidal self‐injury (NSSI) associated with SSRI treatment in a clinical sample of children and adolescents. Methods: An observational, longitudinal, retrospective study using a within‐subject study design including in‐ and outpatients aged 0–17 years treated with SSRIs. Data were obtained from digital medical records and prescription software. Results: N = 365 patients were included (64.1% female), mean (SD) age 14.5 (2.04) years, with primary depression, anxiety or obsessive‐compulsive disorder. No suicides occurred. When comparing the 6‐week period immediately prior to versus following SSRI initiation, the patient proportion with broadly defined suicidality decreased (38.5% vs. 24.2%, p &lt; 0.001) while the proportion with suicide attempts was stable (2.8% vs. 2.8%, p = 1.000). The proportion with NSSI decreased statistically non‐significantly (12.4% vs. 8.4%, p = 0.067). Results from individually standardized observation periods were similar; however, the proportion with suicide attempts decreased statistically non‐significantly and the proportion with NSSI decreased significantly. Suicidality during SSRI treatment was associated with previous suicidality (OR[CI] = 6.0 [2.4–14.8], p &lt; 0.001), depression as indication for SSRI treatment (OR[CI] = 2.1 [1.2–3.7], p = 0.01), female sex (OR[CI] = 2.1 [1.1–4.1], p = 0.02) and previous NSSI (OR[CI] = 2.0 [1.2–3.5], p = 0.01). Conclusion: Suicidality was common in youth treated with SSRIs. The patient proportion with overall suicidality decreased, and the proportion with attempted suicide was stable in the weeks following SSRI initiation. Previous suicidality, depression, female sex and previous NSSI are important predictors for suicidality during SSRI treatment in youth. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1111/acps.13360
    Languages:
      – Code: eng
        Text: English
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        PageCount: 14
        StartPage: 209
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      – SubjectFull: Serotonin uptake inhibitors
        Type: general
      – SubjectFull: Suicidal ideation
        Type: general
      – SubjectFull: Attempted suicide
        Type: general
      – SubjectFull: At-risk youth
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      – SubjectFull: Obsessive-compulsive disorder
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      – SubjectFull: Self-injurious behavior
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      – TitleFull: Suicidality and self‐injury with selective serotonin reuptake inhibitors in youth: Occurrence, predictors and timing.
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            NameFull: Sørensen, Johanne Østerby
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            NameFull: Rasmussen, Annette
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            NameFull: Pagsberg, Anne Katrine
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              M: 02
              Text: Feb2022
              Type: published
              Y: 2022
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