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The impact of HTR1A and HTR1B methylation combined with stress/genotype on early antidepressant efficacy.

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Title: The impact of HTR1A and HTR1B methylation combined with stress/genotype on early antidepressant efficacy.
Authors: Xu, Zhi (AUTHOR), Chen, Zimu (AUTHOR), Shen, Tian (AUTHOR), Chen, Lei (AUTHOR), Tan, Tingting (AUTHOR), Gao, Chenjie (AUTHOR), Chen, Bingwei (AUTHOR), Yuan, Yonggui (AUTHOR), Zhang, Zhijun (AUTHOR)
Source: Psychiatry & Clinical Neurosciences. Feb2022, Vol. 76 Issue 2, p51-57. 7p. 1 Diagram, 3 Charts, 1 Graph.
Subjects: Mental depression, Antidepressants, Methylation, Single nucleotide polymorphisms, Genotypes
Abstract: Aims: Antidepressants are effective in the treatment of major depressive disorder (MDD), while many patients fail to respond to antidepressants. Both 5‐HT1A (HTR1A) and 5‐HT1B (HTR1B) receptors play an important role in antidepressant activity. Meanwhile, DNA methylation is associated with MDD and antidepressant efficacy. In this study we investigate the influence of HTR1A and HTR1B methylation combined with stress/genotype on antidepressant efficacy. Methods: A total of 291 MDD patients and 100 healthy controls received the Life Events Scale (LES) and the Childhood Trauma Questionnaire (CTQ) as stress assessment. Eight single nucleotide polymorphisms (SNPs) of HTR1A and HTR1B involved in antidepressant mechanisms were tested. Methylation status in 181 cytosine‐phosphate‐guanine (CpG) sites of HTR1A and HTR1B were assessed. All MDD patients were divided into response (RES) and non‐response (NRES) after 2 weeks of antidepressant treatment. Logistic regression was conducted for interactions between methylation, NLES/CTQ score and genotype. Results: Low HTR1A‐2‐143 methylation is connected with better antidepressant efficacy in subgroup. Low HTR1A‐2‐143 methylation combined with low CTQ score is related to better antidepressant efficacy. The interaction between high HTR1B methylation with the rs6298 AA/AG genotype affects better antidepressant efficacy. Conclusions: HTR1A and HTR1B methylation combined with stress/genotype is associated with antidepressant efficacy. [ABSTRACT FROM AUTHOR]
Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: The impact of HTR1A and HTR1B methylation combined with stress/genotype on early antidepressant efficacy.
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  Data: <searchLink fieldCode="AR" term="%22Xu%2C+Zhi%22">Xu, Zhi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Zimu%22">Chen, Zimu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shen%2C+Tian%22">Shen, Tian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Lei%22">Chen, Lei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tan%2C+Tingting%22">Tan, Tingting</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gao%2C+Chenjie%22">Gao, Chenjie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Bingwei%22">Chen, Bingwei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yuan%2C+Yonggui%22">Yuan, Yonggui</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Zhijun%22">Zhang, Zhijun</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Psychiatry+%26+Clinical+Neurosciences%22">Psychiatry & Clinical Neurosciences</searchLink>. Feb2022, Vol. 76 Issue 2, p51-57. 7p. 1 Diagram, 3 Charts, 1 Graph.
– Name: Subject
  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Antidepressants%22">Antidepressants</searchLink><br /><searchLink fieldCode="DE" term="%22Methylation%22">Methylation</searchLink><br /><searchLink fieldCode="DE" term="%22Single+nucleotide+polymorphisms%22">Single nucleotide polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22Genotypes%22">Genotypes</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Aims: Antidepressants are effective in the treatment of major depressive disorder (MDD), while many patients fail to respond to antidepressants. Both 5‐HT1A (HTR1A) and 5‐HT1B (HTR1B) receptors play an important role in antidepressant activity. Meanwhile, DNA methylation is associated with MDD and antidepressant efficacy. In this study we investigate the influence of HTR1A and HTR1B methylation combined with stress/genotype on antidepressant efficacy. Methods: A total of 291 MDD patients and 100 healthy controls received the Life Events Scale (LES) and the Childhood Trauma Questionnaire (CTQ) as stress assessment. Eight single nucleotide polymorphisms (SNPs) of HTR1A and HTR1B involved in antidepressant mechanisms were tested. Methylation status in 181 cytosine‐phosphate‐guanine (CpG) sites of HTR1A and HTR1B were assessed. All MDD patients were divided into response (RES) and non‐response (NRES) after 2 weeks of antidepressant treatment. Logistic regression was conducted for interactions between methylation, NLES/CTQ score and genotype. Results: Low HTR1A‐2‐143 methylation is connected with better antidepressant efficacy in subgroup. Low HTR1A‐2‐143 methylation combined with low CTQ score is related to better antidepressant efficacy. The interaction between high HTR1B methylation with the rs6298 AA/AG genotype affects better antidepressant efficacy. Conclusions: HTR1A and HTR1B methylation combined with stress/genotype is associated with antidepressant efficacy. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – SubjectFull: Methylation
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      – SubjectFull: Single nucleotide polymorphisms
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      – SubjectFull: Genotypes
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              Text: Feb2022
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