View in EDS HTML Full Text PDF Full Text

Trends in transdermal fentanyl utilisation and fatal fentanyl overdose across Australia (2003–2015).

Saved in:
Bibliographic Details
Title: Trends in transdermal fentanyl utilisation and fatal fentanyl overdose across Australia (2003–2015).
Authors: Rahman, Shafkat (AUTHOR), Trussell, Alex (AUTHOR), Pearson, Sallie‐Anne (AUTHOR), Buckley, Nicholas A. (AUTHOR), Karanges, Emily A. (AUTHOR), Cairns, Rose (AUTHOR), Litchfield, Melisa (AUTHOR), Todd, Adam (AUTHOR), Gisev, Natasa (AUTHOR)
Source: Drug & Alcohol Review. Feb2022, Vol. 41 Issue 2, p435-443. 9p. 3 Charts, 2 Graphs.
Subjects: Fentanyl, Drug overdose, Transdermal medication, Older people, Intravenous therapy
Geographic Terms: Australia
Abstract: Introduction: Fentanyl‐related overdose is an ongoing concern among countries with high prescription opioid utilisation. This study examines trends in transdermal fentanyl utilisation and fatal fentanyl overdose across Australia between 2003 and 2015, overall, and by age/sex. Methods: This was a retrospective nationwide study of prescription dispensings and coronial records. Transdermal fentanyl utilisation was examined using Pharmaceutical Benefits Scheme dispensing records. Details of fatal fentanyl overdoses were extracted from the National Coronial Information System. Results: Transdermal fentanyl utilisation increased 5.1‐fold between 2003 and 2015, from 0.28 to 1.39 mg/1000 population/day and was consistently higher among females and adults aged ≥85 years. The utilisation of higher strength patches (75 and 100 mcg/h) was more common among males aged 25–44 years. A total of 291 fatal fentanyl overdoses were recorded, increasing from no recorded deaths in 2003 to 2.23 deaths/1 000 000 population in 2015. Rates were higher among males (increasing from 0 to 3.72 deaths/1 000 000 population) and for adults aged 25–44 years (increasing from 0 to 5.34 deaths/1 000 000 population). The number of deaths/kg fentanyl dispensed was highest among males aged <25 years (45.45, 95% confidence interval 21.80–83.59). Most deaths (70.1%) involved the intravenous administration of fentanyl from transdermal patches. Discussion and Conclusions: Rates of transdermal fentanyl utilisation and fatal fentanyl overdose across Australia increased between 2003 and 2015. Although transdermal fentanyl utilisation was consistently greater among females and older adults, rates of fatal fentanyl overdose were highest among younger males. Interventions to reduce extramedical use among this high‐risk population group are necessary to minimise fentanyl‐related harms. [ABSTRACT FROM AUTHOR]
Copyright of Drug & Alcohol Review is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 155130143
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Trends in transdermal fentanyl utilisation and fatal fentanyl overdose across Australia (2003–2015).
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rahman%2C+Shafkat%22&quot;&gt;Rahman, Shafkat&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Trussell%2C+Alex%22&quot;&gt;Trussell, Alex&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Pearson%2C+Sallie‐Anne%22&quot;&gt;Pearson, Sallie‐Anne&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Buckley%2C+Nicholas+A%2E%22&quot;&gt;Buckley, Nicholas A.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Karanges%2C+Emily+A%2E%22&quot;&gt;Karanges, Emily A.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cairns%2C+Rose%22&quot;&gt;Cairns, Rose&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Litchfield%2C+Melisa%22&quot;&gt;Litchfield, Melisa&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Todd%2C+Adam%22&quot;&gt;Todd, Adam&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gisev%2C+Natasa%22&quot;&gt;Gisev, Natasa&lt;/searchLink&gt; (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Drug+%26+Alcohol+Review%22&quot;&gt;Drug &amp; Alcohol Review&lt;/searchLink&gt;. Feb2022, Vol. 41 Issue 2, p435-443. 9p. 3 Charts, 2 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Fentanyl%22&quot;&gt;Fentanyl&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Drug+overdose%22&quot;&gt;Drug overdose&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Transdermal+medication%22&quot;&gt;Transdermal medication&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Older+people%22&quot;&gt;Older people&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Intravenous+therapy%22&quot;&gt;Intravenous therapy&lt;/searchLink&gt;
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Australia%22&quot;&gt;Australia&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Introduction: Fentanyl‐related overdose is an ongoing concern among countries with high prescription opioid utilisation. This study examines trends in transdermal fentanyl utilisation and fatal fentanyl overdose across Australia between 2003 and 2015, overall, and by age/sex. Methods: This was a retrospective nationwide study of prescription dispensings and coronial records. Transdermal fentanyl utilisation was examined using Pharmaceutical Benefits Scheme dispensing records. Details of fatal fentanyl overdoses were extracted from the National Coronial Information System. Results: Transdermal fentanyl utilisation increased 5.1‐fold between 2003 and 2015, from 0.28 to 1.39 mg/1000 population/day and was consistently higher among females and adults aged ≥85 years. The utilisation of higher strength patches (75 and 100 mcg/h) was more common among males aged 25–44 years. A total of 291 fatal fentanyl overdoses were recorded, increasing from no recorded deaths in 2003 to 2.23 deaths/1 000 000 population in 2015. Rates were higher among males (increasing from 0 to 3.72 deaths/1 000 000 population) and for adults aged 25–44 years (increasing from 0 to 5.34 deaths/1 000 000 population). The number of deaths/kg fentanyl dispensed was highest among males aged &lt;25 years (45.45, 95% confidence interval 21.80–83.59). Most deaths (70.1%) involved the intravenous administration of fentanyl from transdermal patches. Discussion and Conclusions: Rates of transdermal fentanyl utilisation and fatal fentanyl overdose across Australia increased between 2003 and 2015. Although transdermal fentanyl utilisation was consistently greater among females and older adults, rates of fatal fentanyl overdose were highest among younger males. Interventions to reduce extramedical use among this high‐risk population group are necessary to minimise fentanyl‐related harms. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Drug &amp; Alcohol Review is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=155130143
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/dar.13391
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 435
    Subjects:
      – SubjectFull: Fentanyl
        Type: general
      – SubjectFull: Drug overdose
        Type: general
      – SubjectFull: Transdermal medication
        Type: general
      – SubjectFull: Older people
        Type: general
      – SubjectFull: Intravenous therapy
        Type: general
      – SubjectFull: Australia
        Type: general
    Titles:
      – TitleFull: Trends in transdermal fentanyl utilisation and fatal fentanyl overdose across Australia (2003–2015).
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Rahman, Shafkat
      – PersonEntity:
          Name:
            NameFull: Trussell, Alex
      – PersonEntity:
          Name:
            NameFull: Pearson, Sallie‐Anne
      – PersonEntity:
          Name:
            NameFull: Buckley, Nicholas A.
      – PersonEntity:
          Name:
            NameFull: Karanges, Emily A.
      – PersonEntity:
          Name:
            NameFull: Cairns, Rose
      – PersonEntity:
          Name:
            NameFull: Litchfield, Melisa
      – PersonEntity:
          Name:
            NameFull: Todd, Adam
      – PersonEntity:
          Name:
            NameFull: Gisev, Natasa
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 02
              Text: Feb2022
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-print
              Value: 09595236
          Numbering:
            – Type: volume
              Value: 41
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: Drug & Alcohol Review
              Type: main
ResultId 1