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Caloric restriction in humans reveals immunometabolic regulators of health span.

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Title: Caloric restriction in humans reveals immunometabolic regulators of health span.
Authors: Spadaro, O., Youm, Y., Shchukina, I., Ryu, S., Sidorov, S., Ravussin, A., Nguyen, K., Aladyeva, E., Predeus, A. N., Smith, S. R., Ravussin, E., Galban, C., Artyomov, M. N., Dixit, V. D.
Source: Science (pre-March 2025). 2/11/2022, Vol. 375 Issue 6581, p671-677. 7p. 3 Diagrams, 1 Graph.
Subjects: Low-calorie diet, Life spans, Platelet activating factor, Adipose tissues, Human bioenergetics measurement, Mitochondria
Abstract: The extension of life span driven by 40% caloric restriction (CR) in rodents causes trade-offs in growth, reproduction, and immune defense that make it difficult to identify therapeutically relevant CR-mimetic targets. We report that about 14% CR for 2 years in healthy humans improved thymopoiesis and was correlated with mobilization of intrathymic ectopic lipid. CR-induced transcriptional reprogramming in adipose tissue implicated pathways regulating mitochondrial bioenergetics, anti-inflammatory responses, and longevity. Expression of the gene Pla2g7 encoding platelet activating factor acetyl hydrolase (PLA2G7) is inhibited in humans undergoing CR. Deletion of Pla2g7 in mice showed decreased thymic lipoatrophy, protection against age-related inflammation, lowered NLRP3 inflammasome activation, and improved metabolic health. Therefore, the reduction of PLA2G7 may mediate the immunometabolic effects of CR and could potentially be harnessed to lower inflammation and extend the health span. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
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  Data: Caloric restriction in humans reveals immunometabolic regulators of health span.
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  Data: <searchLink fieldCode="AR" term="%22Spadaro%2C+O%2E%22">Spadaro, O.</searchLink><br /><searchLink fieldCode="AR" term="%22Youm%2C+Y%2E%22">Youm, Y.</searchLink><br /><searchLink fieldCode="AR" term="%22Shchukina%2C+I%2E%22">Shchukina, I.</searchLink><br /><searchLink fieldCode="AR" term="%22Ryu%2C+S%2E%22">Ryu, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Sidorov%2C+S%2E%22">Sidorov, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Ravussin%2C+A%2E%22">Ravussin, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Nguyen%2C+K%2E%22">Nguyen, K.</searchLink><br /><searchLink fieldCode="AR" term="%22Aladyeva%2C+E%2E%22">Aladyeva, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Predeus%2C+A%2E+N%2E%22">Predeus, A. N.</searchLink><br /><searchLink fieldCode="AR" term="%22Smith%2C+S%2E+R%2E%22">Smith, S. R.</searchLink><br /><searchLink fieldCode="AR" term="%22Ravussin%2C+E%2E%22">Ravussin, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Galban%2C+C%2E%22">Galban, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Artyomov%2C+M%2E+N%2E%22">Artyomov, M. N.</searchLink><br /><searchLink fieldCode="AR" term="%22Dixit%2C+V%2E+D%2E%22">Dixit, V. D.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 2/11/2022, Vol. 375 Issue 6581, p671-677. 7p. 3 Diagrams, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Low-calorie+diet%22">Low-calorie diet</searchLink><br /><searchLink fieldCode="DE" term="%22Life+spans%22">Life spans</searchLink><br /><searchLink fieldCode="DE" term="%22Platelet+activating+factor%22">Platelet activating factor</searchLink><br /><searchLink fieldCode="DE" term="%22Adipose+tissues%22">Adipose tissues</searchLink><br /><searchLink fieldCode="DE" term="%22Human+bioenergetics+measurement%22">Human bioenergetics measurement</searchLink><br /><searchLink fieldCode="DE" term="%22Mitochondria%22">Mitochondria</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: The extension of life span driven by 40% caloric restriction (CR) in rodents causes trade-offs in growth, reproduction, and immune defense that make it difficult to identify therapeutically relevant CR-mimetic targets. We report that about 14% CR for 2 years in healthy humans improved thymopoiesis and was correlated with mobilization of intrathymic ectopic lipid. CR-induced transcriptional reprogramming in adipose tissue implicated pathways regulating mitochondrial bioenergetics, anti-inflammatory responses, and longevity. Expression of the gene Pla2g7 encoding platelet activating factor acetyl hydrolase (PLA2G7) is inhibited in humans undergoing CR. Deletion of Pla2g7 in mice showed decreased thymic lipoatrophy, protection against age-related inflammation, lowered NLRP3 inflammasome activation, and improved metabolic health. Therefore, the reduction of PLA2G7 may mediate the immunometabolic effects of CR and could potentially be harnessed to lower inflammation and extend the health span. [ABSTRACT FROM AUTHOR]
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  Group: Ab
  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=155197981
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        Value: 10.1126/science.abg7292
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      – Code: eng
        Text: English
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        PageCount: 7
        StartPage: 671
    Subjects:
      – SubjectFull: Low-calorie diet
        Type: general
      – SubjectFull: Life spans
        Type: general
      – SubjectFull: Platelet activating factor
        Type: general
      – SubjectFull: Adipose tissues
        Type: general
      – SubjectFull: Human bioenergetics measurement
        Type: general
      – SubjectFull: Mitochondria
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      – TitleFull: Caloric restriction in humans reveals immunometabolic regulators of health span.
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              Text: 2/11/2022
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              Y: 2022
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