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The effectiveness of functional electrical stimulation of the legs in patients with heart failure: A systematic review and meta-analysis of randomized controlled trials.

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Title: The effectiveness of functional electrical stimulation of the legs in patients with heart failure: A systematic review and meta-analysis of randomized controlled trials.
Authors: Wang, Hsun-Yi, Chen, Yu-Hsuan, Kuan, Yi-Chun, Huang, Shih-Wei, Lin, Li-Fong, Chen, Hung-Chou
Source: Clinical Rehabilitation. Mar2022, Vol. 36 Issue 3, p303-316. 14p.
Subjects: Heart failure treatment, Online information services, Meta-analysis, Information storage & retrieval systems, Medical databases, Medical information storage & retrieval systems, Confidence intervals, Systematic reviews, Cardiopulmonary system physiology, Leg, Electric stimulation, Muscle strength, Quality of life, MEDLINE
Abstract: Objective: To investigate the effectiveness of functional electrical stimulation of the legs in patients with heart failure. Methods: Data were obtained from PubMed, Cochrane Library, and Embase databases until August 12, 2021. We included randomized controlled trials that evaluated the effects of functional electrical stimulation applied to the legs of patients with heart failure, namely changes in cardiopulmonary function, muscle strength, and quality of life. Results: In total, 14 randomized controlled trials (consisting of 518 patients) were included in our article. Pooled estimates demonstrated that functional electrical stimulation significantly improved peak oxygen consumption (peak VO2; standardized mean difference = 0.33, 95% confidence interval = 0.07–0.59, eight randomized controlled trials, n = 321), 6-min walking distance (mean difference = 48.03 m, 95% confidence interval = 28.50–67.57 m, 10 randomized controlled trials, n = 380), and Minnesota Living with Heart Failure Questionnaire quality of life score (mean difference = − 8.23, 95% confidence interval = − 12.64 to − 3.83, nine randomized controlled trials, n = 383). Muscle strength of lower extremities was not significantly improved in the functional electrical stimulation group compared with that in the control group (standardized mean difference = 0.26, 95% confidence interval = − 0.18 to 0.71, five randomized controlled trials, n = 218). Furthermore, the subgroup analysis revealed that functional electrical stimulation significantly improved peak VO2, 6-min walking distance, and Minnesota Living with Heart Failure Questionnaire quality of life score in the heart failure with reduced ejection fraction and heart failure with preserved ejection fraction subgroups. Conclusion: Functional electrical stimulation can effectively improve the cardiopulmonary function and quality of life in patients with heart failure. However, functional electrical stimulation did not significantly improve muscle strength in the legs. [ABSTRACT FROM AUTHOR]
Copyright of Clinical Rehabilitation is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
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  Data: The effectiveness of functional electrical stimulation of the legs in patients with heart failure: A systematic review and meta-analysis of randomized controlled trials.
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  Data: <searchLink fieldCode="AR" term="%22Wang%2C+Hsun-Yi%22">Wang, Hsun-Yi</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Yu-Hsuan%22">Chen, Yu-Hsuan</searchLink><br /><searchLink fieldCode="AR" term="%22Kuan%2C+Yi-Chun%22">Kuan, Yi-Chun</searchLink><br /><searchLink fieldCode="AR" term="%22Huang%2C+Shih-Wei%22">Huang, Shih-Wei</searchLink><br /><searchLink fieldCode="AR" term="%22Lin%2C+Li-Fong%22">Lin, Li-Fong</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Hung-Chou%22">Chen, Hung-Chou</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Clinical+Rehabilitation%22">Clinical Rehabilitation</searchLink>. Mar2022, Vol. 36 Issue 3, p303-316. 14p.
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  Data: <searchLink fieldCode="DE" term="%22Heart+failure+treatment%22">Heart failure treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Online+information+services%22">Online information services</searchLink><br /><searchLink fieldCode="DE" term="%22Meta-analysis%22">Meta-analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Information+storage+%26+retrieval+systems%22">Information storage & retrieval systems</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+databases%22">Medical databases</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+information+storage+%26+retrieval+systems%22">Medical information storage & retrieval systems</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Systematic+reviews%22">Systematic reviews</searchLink><br /><searchLink fieldCode="DE" term="%22Cardiopulmonary+system+physiology%22">Cardiopulmonary system physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Leg%22">Leg</searchLink><br /><searchLink fieldCode="DE" term="%22Electric+stimulation%22">Electric stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22Muscle+strength%22">Muscle strength</searchLink><br /><searchLink fieldCode="DE" term="%22Quality+of+life%22">Quality of life</searchLink><br /><searchLink fieldCode="DE" term="%22MEDLINE%22">MEDLINE</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: To investigate the effectiveness of functional electrical stimulation of the legs in patients with heart failure. Methods: Data were obtained from PubMed, Cochrane Library, and Embase databases until August 12, 2021. We included randomized controlled trials that evaluated the effects of functional electrical stimulation applied to the legs of patients with heart failure, namely changes in cardiopulmonary function, muscle strength, and quality of life. Results: In total, 14 randomized controlled trials (consisting of 518 patients) were included in our article. Pooled estimates demonstrated that functional electrical stimulation significantly improved peak oxygen consumption (peak VO2; standardized mean difference = 0.33, 95% confidence interval = 0.07–0.59, eight randomized controlled trials, n = 321), 6-min walking distance (mean difference = 48.03 m, 95% confidence interval = 28.50–67.57 m, 10 randomized controlled trials, n = 380), and Minnesota Living with Heart Failure Questionnaire quality of life score (mean difference = − 8.23, 95% confidence interval = − 12.64 to − 3.83, nine randomized controlled trials, n = 383). Muscle strength of lower extremities was not significantly improved in the functional electrical stimulation group compared with that in the control group (standardized mean difference = 0.26, 95% confidence interval = − 0.18 to 0.71, five randomized controlled trials, n = 218). Furthermore, the subgroup analysis revealed that functional electrical stimulation significantly improved peak VO2, 6-min walking distance, and Minnesota Living with Heart Failure Questionnaire quality of life score in the heart failure with reduced ejection fraction and heart failure with preserved ejection fraction subgroups. Conclusion: Functional electrical stimulation can effectively improve the cardiopulmonary function and quality of life in patients with heart failure. However, functional electrical stimulation did not significantly improve muscle strength in the legs. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Clinical Rehabilitation is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1177/02692155211056999
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        Text: English
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      – SubjectFull: Heart failure treatment
        Type: general
      – SubjectFull: Online information services
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      – SubjectFull: Meta-analysis
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      – SubjectFull: Medical information storage & retrieval systems
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      – SubjectFull: Systematic reviews
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      – SubjectFull: Cardiopulmonary system physiology
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      – SubjectFull: Leg
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              Text: Mar2022
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