Progressive supranuclear palsy with marked ventricular dilatation mimicking normal pressure hydrocephalus.
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| Title: | Progressive supranuclear palsy with marked ventricular dilatation mimicking normal pressure hydrocephalus. |
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| Authors: | Quattrone, Andrea (AUTHOR), Sarica, Alessia (AUTHOR), La Torre, Domenico (AUTHOR), Morelli, Maurizio (AUTHOR), Mechelli, Alessandro (AUTHOR), Arcuri, Pier Paolo (AUTHOR), Quattrone, Aldo (AUTHOR) |
| Source: | Neurological Sciences. Mar2022, Vol. 43 Issue 3, p1783-1790. 8p. |
| Subjects: | Progressive supranuclear palsy, Hydrocephalus, Patient care |
| Abstract: | Background: Progressive supranuclear palsy (PSP) patients can show ventricular enlargement mimicking normal pressure hydrocephalus (NPH). The aim of this study was to distinguish PSP patients with marked ventricular dilatation (PSP-vd) from those with normal ventricular system and to evaluate the coexistence of NPH in PSP-vd patients. Methods: One hundred three probable PSP patients, 18 definite NPH patients, and 41 control subjects were enrolled in the study. Evans index (EI) > 0.32 associated with callosal angle (CA) < 100° was used to identify PSP-vd patients. Automated ventricular volumetry (AVV) and Magnetic Resonance Hydrocephalic Index (MRHI) were performed on T1-weighted MR images to evaluate the presence of NPH in PSP-vd patients. Results: Twelve (11.6%) out of 103 PSP patients had both abnormal EI and CA values (PSP-vd). In two of these 12 patients, AVV and MRHI values suggested PSP + NPH. In the remaining 10 PSP-vd patients, AVV and MRHI values were higher than PSP patients with normal ventricular system and controls, but lower than PSP + NPH and NPH patients, suggesting a non-hydrocephalic ventricular enlargement. Discussion: Our study provides evidence that the combination of EI and CA biomarkers allowed to identify PSP patients with marked ventricular dilatation mimicking NPH. Only a few of these patients had PSP + NPH. Recognition of these PSP patients with enlarged ventricles can positively impact the care of this disease, helping clinicians to identify patients with PSP + NPH who could benefit from shunt procedure and avoid surgery in those with enlarged ventricles without NPH. [ABSTRACT FROM AUTHOR] |
| Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 155382577 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Progressive supranuclear palsy with marked ventricular dilatation mimicking normal pressure hydrocephalus. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Quattrone%2C+Andrea%22">Quattrone, Andrea</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sarica%2C+Alessia%22">Sarica, Alessia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22La+Torre%2C+Domenico%22">La Torre, Domenico</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Morelli%2C+Maurizio%22">Morelli, Maurizio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mechelli%2C+Alessandro%22">Mechelli, Alessandro</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Arcuri%2C+Pier+Paolo%22">Arcuri, Pier Paolo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Quattrone%2C+Aldo%22">Quattrone, Aldo</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Mar2022, Vol. 43 Issue 3, p1783-1790. 8p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Progressive+supranuclear+palsy%22">Progressive supranuclear palsy</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrocephalus%22">Hydrocephalus</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+care%22">Patient care</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Progressive supranuclear palsy (PSP) patients can show ventricular enlargement mimicking normal pressure hydrocephalus (NPH). The aim of this study was to distinguish PSP patients with marked ventricular dilatation (PSP-vd) from those with normal ventricular system and to evaluate the coexistence of NPH in PSP-vd patients. Methods: One hundred three probable PSP patients, 18 definite NPH patients, and 41 control subjects were enrolled in the study. Evans index (EI) > 0.32 associated with callosal angle (CA) < 100° was used to identify PSP-vd patients. Automated ventricular volumetry (AVV) and Magnetic Resonance Hydrocephalic Index (MRHI) were performed on T1-weighted MR images to evaluate the presence of NPH in PSP-vd patients. Results: Twelve (11.6%) out of 103 PSP patients had both abnormal EI and CA values (PSP-vd). In two of these 12 patients, AVV and MRHI values suggested PSP + NPH. In the remaining 10 PSP-vd patients, AVV and MRHI values were higher than PSP patients with normal ventricular system and controls, but lower than PSP + NPH and NPH patients, suggesting a non-hydrocephalic ventricular enlargement. Discussion: Our study provides evidence that the combination of EI and CA biomarkers allowed to identify PSP patients with marked ventricular dilatation mimicking NPH. Only a few of these patients had PSP + NPH. Recognition of these PSP patients with enlarged ventricles can positively impact the care of this disease, helping clinicians to identify patients with PSP + NPH who could benefit from shunt procedure and avoid surgery in those with enlarged ventricles without NPH. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10072-021-05594-4 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 1783 Subjects: – SubjectFull: Progressive supranuclear palsy Type: general – SubjectFull: Hydrocephalus Type: general – SubjectFull: Patient care Type: general Titles: – TitleFull: Progressive supranuclear palsy with marked ventricular dilatation mimicking normal pressure hydrocephalus. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Quattrone, Andrea – PersonEntity: Name: NameFull: Sarica, Alessia – PersonEntity: Name: NameFull: La Torre, Domenico – PersonEntity: Name: NameFull: Morelli, Maurizio – PersonEntity: Name: NameFull: Mechelli, Alessandro – PersonEntity: Name: NameFull: Arcuri, Pier Paolo – PersonEntity: Name: NameFull: Quattrone, Aldo IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 15901874 Numbering: – Type: volume Value: 43 – Type: issue Value: 3 Titles: – TitleFull: Neurological Sciences Type: main |
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