View in EDS HTML Full Text PDF Full Text

The role of efferocytosis in neuro-degenerative diseases.

Saved in:
Bibliographic Details
Title: The role of efferocytosis in neuro-degenerative diseases.
Authors: Taheri, Forough (AUTHOR), Taghizadeh, Eskandar (AUTHOR), Navashenaq, Jamshid Gholizadeh (AUTHOR), Rezaee, Mehdi (AUTHOR), Gheibihayat, Seyed Mohammad (AUTHOR)
Source: Neurological Sciences. Mar2022, Vol. 43 Issue 3, p1593-1603. 11p.
Subjects: Neurodegeneration, Inflammation, Cell death, Cellular signal transduction, Therapeutics, Chronic diseases
Abstract: Efferocytosis has a critical role in maintaining tissues and organs' homeostasis by removing apoptotic cells. It is essential for human health, and disturbances in efferocytosis may result indifferent illnesses. In case of inadequate clearance of the dead cells, the content in the cells would be released. In fact, it induces some damages to the tissue and leads to the prolonged inflammation, so unsuitable phagocytosis of the apoptotic cells is involved in occurrence as well as expansion of numerous human chronic inflammatory diseases. Studies have shown age dependence of the neuro-degenerative diseases, which are largely due to the neuro-inflammation and the loss of neurons and thus cause the brain's functional disorders. Efferocytosis is coupled to anti-inflammatory responses that contribute to the elimination of the dying neurons in neuro-degenerative diseases, so its disruption may make a risk factor in numerous human chronic inflammatory diseases such as multiple sclerosis, Alzheimer's disease, glioblastoma, and Rett syndrome. This study is a review of the efferocytosis molecular pathways and their role in neuro-degenerative diseases in order to discover a new treatment option to cure patients. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 155382610
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: The role of efferocytosis in neuro-degenerative diseases.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Taheri%2C+Forough%22">Taheri, Forough</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Taghizadeh%2C+Eskandar%22">Taghizadeh, Eskandar</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Navashenaq%2C+Jamshid+Gholizadeh%22">Navashenaq, Jamshid Gholizadeh</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rezaee%2C+Mehdi%22">Rezaee, Mehdi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gheibihayat%2C+Seyed+Mohammad%22">Gheibihayat, Seyed Mohammad</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Mar2022, Vol. 43 Issue 3, p1593-1603. 11p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Neurodegeneration%22">Neurodegeneration</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammation%22">Inflammation</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+death%22">Cell death</searchLink><br /><searchLink fieldCode="DE" term="%22Cellular+signal+transduction%22">Cellular signal transduction</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink><br /><searchLink fieldCode="DE" term="%22Chronic+diseases%22">Chronic diseases</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Efferocytosis has a critical role in maintaining tissues and organs' homeostasis by removing apoptotic cells. It is essential for human health, and disturbances in efferocytosis may result indifferent illnesses. In case of inadequate clearance of the dead cells, the content in the cells would be released. In fact, it induces some damages to the tissue and leads to the prolonged inflammation, so unsuitable phagocytosis of the apoptotic cells is involved in occurrence as well as expansion of numerous human chronic inflammatory diseases. Studies have shown age dependence of the neuro-degenerative diseases, which are largely due to the neuro-inflammation and the loss of neurons and thus cause the brain's functional disorders. Efferocytosis is coupled to anti-inflammatory responses that contribute to the elimination of the dying neurons in neuro-degenerative diseases, so its disruption may make a risk factor in numerous human chronic inflammatory diseases such as multiple sclerosis, Alzheimer's disease, glioblastoma, and Rett syndrome. This study is a review of the efferocytosis molecular pathways and their role in neuro-degenerative diseases in order to discover a new treatment option to cure patients. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=155382610
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s10072-021-05835-6
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 11
        StartPage: 1593
    Subjects:
      – SubjectFull: Neurodegeneration
        Type: general
      – SubjectFull: Inflammation
        Type: general
      – SubjectFull: Cell death
        Type: general
      – SubjectFull: Cellular signal transduction
        Type: general
      – SubjectFull: Therapeutics
        Type: general
      – SubjectFull: Chronic diseases
        Type: general
    Titles:
      – TitleFull: The role of efferocytosis in neuro-degenerative diseases.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Taheri, Forough
      – PersonEntity:
          Name:
            NameFull: Taghizadeh, Eskandar
      – PersonEntity:
          Name:
            NameFull: Navashenaq, Jamshid Gholizadeh
      – PersonEntity:
          Name:
            NameFull: Rezaee, Mehdi
      – PersonEntity:
          Name:
            NameFull: Gheibihayat, Seyed Mohammad
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 03
              Text: Mar2022
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-print
              Value: 15901874
          Numbering:
            – Type: volume
              Value: 43
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: Neurological Sciences
              Type: main
ResultId 1