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The effects of callous-unemotional traits and aggression subtypes on amygdala activity in response to negative faces.

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Title: The effects of callous-unemotional traits and aggression subtypes on amygdala activity in response to negative faces.
Authors: Aggensteiner, Pascal-M, Holz, Nathalie E., Böttinger, Boris W., Baumeister, Sarah, Hohmann, Sarah, Werhahn, Julia E., Naaijen, Jilly, Ilbegi, Shahrzad, Glennon, Jeffrey C., Hoekstra, Pieter J., Dietrich, Andrea, Deters, Renee Kleine, Saam, Melanie C., Schulze, Ulrike M. E., Lythgoe, David J., Sethi, Arjun, Craig, Michael C., Mastroianni, Mathilde, Sagar-Ouriaghli, Ilyas, Santosh, Paramala J.
Source: Psychological Medicine. Feb2022, Vol. 52 Issue 3, p476-484. 9p.
Subjects: Statistics, Analysis of variance, Facial expression, Magnetic resonance imaging, Behavior disorders, Behavior disorders in children, T-test (Statistics), Pearson correlation (Statistics), Descriptive statistics, Chi-squared test, Questionnaires, Repeated measures design, Emotions, Aggression (Psychology), Amygdaloid body, Antisocial personality disorders, Data analysis software, Data analysis
Abstract: Background: Brain imaging studies have shown altered amygdala activity during emotion processing in children and adolescents with oppositional defiant disorder (ODD) and conduct disorder (CD) compared to typically developing children and adolescents (TD). Here we aimed to assess whether aggression-related subtypes (reactive and proactive aggression) and callous-unemotional (CU) traits predicted variation in amygdala activity and skin conductance (SC) response during emotion processing. Methods: We included 177 participants (n = 108 cases with disruptive behaviour and/or ODD/CD and n = 69 TD), aged 8–18 years, across nine sites in Europe, as part of the EU Aggressotype and MATRICS projects. All participants performed an emotional face-matching functional magnetic resonance imaging task. Results: Differences between cases and TD in affective processing, as well as specificity of activation patterns for aggression subtypes and CU traits, were assessed. Simultaneous SC recordings were acquired in a subsample (n = 63). Cases compared to TDs showed higher amygdala activity in response to negative faces (fearful and angry) v. shapes. Subtyping cases according to aggression-related subtypes did not significantly influence on amygdala activity; while stratification based on CU traits was more sensitive and revealed decreased amygdala activity in the high CU group. SC responses were significantly lower in cases and negatively correlated with CU traits, reactive and proactive aggression. Conclusions: Our results showed differences in amygdala activity and SC responses to emotional faces between cases with ODD/CD and TD, while CU traits moderate both central (amygdala) and peripheral (SC) responses. Our insights regarding subtypes and trait-specific aggression could be used for improved diagnostics and personalized treatment. [ABSTRACT FROM AUTHOR]
Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: The effects of callous-unemotional traits and aggression subtypes on amygdala activity in response to negative faces.
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  Data: <searchLink fieldCode="AR" term="%22Aggensteiner%2C+Pascal-M%22">Aggensteiner, Pascal-M</searchLink><br /><searchLink fieldCode="AR" term="%22Holz%2C+Nathalie+E%2E%22">Holz, Nathalie E.</searchLink><br /><searchLink fieldCode="AR" term="%22Böttinger%2C+Boris+W%2E%22">Böttinger, Boris W.</searchLink><br /><searchLink fieldCode="AR" term="%22Baumeister%2C+Sarah%22">Baumeister, Sarah</searchLink><br /><searchLink fieldCode="AR" term="%22Hohmann%2C+Sarah%22">Hohmann, Sarah</searchLink><br /><searchLink fieldCode="AR" term="%22Werhahn%2C+Julia+E%2E%22">Werhahn, Julia E.</searchLink><br /><searchLink fieldCode="AR" term="%22Naaijen%2C+Jilly%22">Naaijen, Jilly</searchLink><br /><searchLink fieldCode="AR" term="%22Ilbegi%2C+Shahrzad%22">Ilbegi, Shahrzad</searchLink><br /><searchLink fieldCode="AR" term="%22Glennon%2C+Jeffrey+C%2E%22">Glennon, Jeffrey C.</searchLink><br /><searchLink fieldCode="AR" term="%22Hoekstra%2C+Pieter+J%2E%22">Hoekstra, Pieter J.</searchLink><br /><searchLink fieldCode="AR" term="%22Dietrich%2C+Andrea%22">Dietrich, Andrea</searchLink><br /><searchLink fieldCode="AR" term="%22Deters%2C+Renee+Kleine%22">Deters, Renee Kleine</searchLink><br /><searchLink fieldCode="AR" term="%22Saam%2C+Melanie+C%2E%22">Saam, Melanie C.</searchLink><br /><searchLink fieldCode="AR" term="%22Schulze%2C+Ulrike+M%2E+E%2E%22">Schulze, Ulrike M. E.</searchLink><br /><searchLink fieldCode="AR" term="%22Lythgoe%2C+David+J%2E%22">Lythgoe, David J.</searchLink><br /><searchLink fieldCode="AR" term="%22Sethi%2C+Arjun%22">Sethi, Arjun</searchLink><br /><searchLink fieldCode="AR" term="%22Craig%2C+Michael+C%2E%22">Craig, Michael C.</searchLink><br /><searchLink fieldCode="AR" term="%22Mastroianni%2C+Mathilde%22">Mastroianni, Mathilde</searchLink><br /><searchLink fieldCode="AR" term="%22Sagar-Ouriaghli%2C+Ilyas%22">Sagar-Ouriaghli, Ilyas</searchLink><br /><searchLink fieldCode="AR" term="%22Santosh%2C+Paramala+J%2E%22">Santosh, Paramala J.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Psychological+Medicine%22">Psychological Medicine</searchLink>. Feb2022, Vol. 52 Issue 3, p476-484. 9p.
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  Data: Background: Brain imaging studies have shown altered amygdala activity during emotion processing in children and adolescents with oppositional defiant disorder (ODD) and conduct disorder (CD) compared to typically developing children and adolescents (TD). Here we aimed to assess whether aggression-related subtypes (reactive and proactive aggression) and callous-unemotional (CU) traits predicted variation in amygdala activity and skin conductance (SC) response during emotion processing. Methods: We included 177 participants (n = 108 cases with disruptive behaviour and/or ODD/CD and n = 69 TD), aged 8–18 years, across nine sites in Europe, as part of the EU Aggressotype and MATRICS projects. All participants performed an emotional face-matching functional magnetic resonance imaging task. Results: Differences between cases and TD in affective processing, as well as specificity of activation patterns for aggression subtypes and CU traits, were assessed. Simultaneous SC recordings were acquired in a subsample (n = 63). Cases compared to TDs showed higher amygdala activity in response to negative faces (fearful and angry) v. shapes. Subtyping cases according to aggression-related subtypes did not significantly influence on amygdala activity; while stratification based on CU traits was more sensitive and revealed decreased amygdala activity in the high CU group. SC responses were significantly lower in cases and negatively correlated with CU traits, reactive and proactive aggression. Conclusions: Our results showed differences in amygdala activity and SC responses to emotional faces between cases with ODD/CD and TD, while CU traits moderate both central (amygdala) and peripheral (SC) responses. Our insights regarding subtypes and trait-specific aggression could be used for improved diagnostics and personalized treatment. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1017/S0033291720002111
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