α7 nicotinic acetylcholine receptor modulation of accumbal dopamine release covaries with novelty seeking.
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| Title: | α7 nicotinic acetylcholine receptor modulation of accumbal dopamine release covaries with novelty seeking. |
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| Authors: | Leach, Amy C. (AUTHOR), Pitts, Elizabeth G. (AUTHOR), Siciliano, Cody A. (AUTHOR), Ferris, Mark J. (AUTHOR) |
| Source: | European Journal of Neuroscience. Mar2022, Vol. 55 Issue 5, p1162-1173. 12p. 4 Graphs. |
| Subjects: | Nicotinic acetylcholine receptors, Dopamine, Nucleus accumbens, Methyl aspartate receptors |
| Abstract: | Heightened novelty‐seeking phenotypes are associated with a range of behavioural traits including susceptibility to drug use. These relationships are recapitulated in preclinical models, where rats that exhibit increased exploratory activity in novel environments (high responders—HR) acquire self‐administration of psychostimulants more rapidly compared to rats that display low novelty exploration (low responders—LR). Dopamine release dynamics in the nucleus accumbens (NAc) covaries with response to novelty, and differences in dopaminergic signalling are thought to be a major underlying driver of the link between novelty seeking and drug use vulnerability. Accumbal dopamine release is controlled by local microcircuits including modulation through glutamatergic and nicotinic acetylcholine receptor (nAChR) systems, but whether these mechanisms contribute to disparate dopamine signalling across novelty phenotypes is unclear. Here, we used ex vivo voltammetry in the NAc of rats to determine if α7 nAChRs contribute to differential dopamine dynamics associated with individual differences in novelty exploration. We found that blockade of α7 nAChRs attenuates tonic dopamine release evoked by low‐frequency stimulations across phenotypes but that phasic release is decreased in LRs while HRs are unaffected. These stimulation frequency‐ and phenotype‐dependent effects result in a decreased dynamic range of release exclusively in LRs. Furthermore, we found that differential α7 modulation of dopamine release in LRs is dependent on AMPA but not NMDA receptors. These results help to form an understanding of the local NAc microcircuitry and provide a potential mechanism for covariance of dopamine dynamics and sensitivity to the reinforcing effects of drugs of abuse. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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