Salivary Cortisol and Alpha-Amylase in Posttraumatic Stress Disorder and Their Potential Role in the Evaluation of Cognitive Behavioral Treatment Outcomes.
Saved in:
| Title: | Salivary Cortisol and Alpha-Amylase in Posttraumatic Stress Disorder and Their Potential Role in the Evaluation of Cognitive Behavioral Treatment Outcomes. |
|---|---|
| Authors: | Schumacher, Sarah, Engel, Sinha, Niemeyer, Helen, Küster, Annika, Burchert, Sebastian, Skoluda, Nadine, Rau, Heinrich, Nater, Urs M., Willmund, Gerd-Dieter, Knaevelsrud, Christine |
| Source: | Journal of Traumatic Stress. Feb2022, Vol. 35 Issue 1, p78-89. 12p. |
| Subjects: | Post-traumatic stress disorder, Psychobiology, Behavioral assessment, Alpha-amylase, Cognitive therapy, Treatment effectiveness |
| Abstract: | Alterations in HPA-axis and autonomic nervous system activity have been associated with posttraumatic stress disorder (PTSD) development and maintenance and are potentially associated with trauma-focused cognitive behavioral therapy (TF-CBT) outcomes. We examined the role of salivary cortisol (sCort) and alpha-amylase (sAA) in PTSD and TF-CBT outcomes in German Armed Forces service members (N = 100). Participants categorized as PTSD patients (n = 39), previously deployed healthy controls (n = 33), and nondeployed healthy controls (n = 28) provided diurnal profiles of sCort and sAA; PTSD patients provided samples before, immediately after, and 3 months after an internet-based TF-CBT intervention. No group differences emerged regarding total daily sCort and sAA output or daily slopes, ps = .224-.897, fs = 0.05-0.24. Participants with PTSD demonstrated a significantly attenuated sCort awakening response compared to deployed, p = .021, d = 0.59, but not nondeployed controls, p = .918, d = 0.08. Moreover, a significantly steeper sAA awakening response emerged in PTSD patients, p = .034, d = 0.67, and deployed controls, p = .014, d = 0.80, compared to nondeployed controls. From pretreatment to posttreatment (n = 21) and posttreatment to follow-up (n = 14), stable sCort, ps = .282-.628, fs = 0.34-0.49, and sAA concentrations, ps = .068-.758, fs = 0.24-1.13 paralleled a nonsignificant treatment effect. Both PTSD and trauma exposure were associated with alterations in awakening responses, but further investigation is needed to determine whether the observed correspondence remains when PTSD symptoms significantly decline. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Traumatic Stress is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 155881094 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Salivary Cortisol and Alpha-Amylase in Posttraumatic Stress Disorder and Their Potential Role in the Evaluation of Cognitive Behavioral Treatment Outcomes. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Schumacher%2C+Sarah%22">Schumacher, Sarah</searchLink><br /><searchLink fieldCode="AR" term="%22Engel%2C+Sinha%22">Engel, Sinha</searchLink><br /><searchLink fieldCode="AR" term="%22Niemeyer%2C+Helen%22">Niemeyer, Helen</searchLink><br /><searchLink fieldCode="AR" term="%22Küster%2C+Annika%22">Küster, Annika</searchLink><br /><searchLink fieldCode="AR" term="%22Burchert%2C+Sebastian%22">Burchert, Sebastian</searchLink><br /><searchLink fieldCode="AR" term="%22Skoluda%2C+Nadine%22">Skoluda, Nadine</searchLink><br /><searchLink fieldCode="AR" term="%22Rau%2C+Heinrich%22">Rau, Heinrich</searchLink><br /><searchLink fieldCode="AR" term="%22Nater%2C+Urs+M%2E%22">Nater, Urs M.</searchLink><br /><searchLink fieldCode="AR" term="%22Willmund%2C+Gerd-Dieter%22">Willmund, Gerd-Dieter</searchLink><br /><searchLink fieldCode="AR" term="%22Knaevelsrud%2C+Christine%22">Knaevelsrud, Christine</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Traumatic+Stress%22">Journal of Traumatic Stress</searchLink>. Feb2022, Vol. 35 Issue 1, p78-89. 12p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Post-traumatic+stress+disorder%22">Post-traumatic stress disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Psychobiology%22">Psychobiology</searchLink><br /><searchLink fieldCode="DE" term="%22Behavioral+assessment%22">Behavioral assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Alpha-amylase%22">Alpha-amylase</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+therapy%22">Cognitive therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Alterations in HPA-axis and autonomic nervous system activity have been associated with posttraumatic stress disorder (PTSD) development and maintenance and are potentially associated with trauma-focused cognitive behavioral therapy (TF-CBT) outcomes. We examined the role of salivary cortisol (sCort) and alpha-amylase (sAA) in PTSD and TF-CBT outcomes in German Armed Forces service members (N = 100). Participants categorized as PTSD patients (n = 39), previously deployed healthy controls (n = 33), and nondeployed healthy controls (n = 28) provided diurnal profiles of sCort and sAA; PTSD patients provided samples before, immediately after, and 3 months after an internet-based TF-CBT intervention. No group differences emerged regarding total daily sCort and sAA output or daily slopes, ps = .224-.897, fs = 0.05-0.24. Participants with PTSD demonstrated a significantly attenuated sCort awakening response compared to deployed, p = .021, d = 0.59, but not nondeployed controls, p = .918, d = 0.08. Moreover, a significantly steeper sAA awakening response emerged in PTSD patients, p = .034, d = 0.67, and deployed controls, p = .014, d = 0.80, compared to nondeployed controls. From pretreatment to posttreatment (n = 21) and posttreatment to follow-up (n = 14), stable sCort, ps = .282-.628, fs = 0.34-0.49, and sAA concentrations, ps = .068-.758, fs = 0.24-1.13 paralleled a nonsignificant treatment effect. Both PTSD and trauma exposure were associated with alterations in awakening responses, but further investigation is needed to determine whether the observed correspondence remains when PTSD symptoms significantly decline. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Traumatic Stress is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=155881094 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/jts.22683 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 78 Subjects: – SubjectFull: Post-traumatic stress disorder Type: general – SubjectFull: Psychobiology Type: general – SubjectFull: Behavioral assessment Type: general – SubjectFull: Alpha-amylase Type: general – SubjectFull: Cognitive therapy Type: general – SubjectFull: Treatment effectiveness Type: general Titles: – TitleFull: Salivary Cortisol and Alpha-Amylase in Posttraumatic Stress Disorder and Their Potential Role in the Evaluation of Cognitive Behavioral Treatment Outcomes. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Schumacher, Sarah – PersonEntity: Name: NameFull: Engel, Sinha – PersonEntity: Name: NameFull: Niemeyer, Helen – PersonEntity: Name: NameFull: Küster, Annika – PersonEntity: Name: NameFull: Burchert, Sebastian – PersonEntity: Name: NameFull: Skoluda, Nadine – PersonEntity: Name: NameFull: Rau, Heinrich – PersonEntity: Name: NameFull: Nater, Urs M. – PersonEntity: Name: NameFull: Willmund, Gerd-Dieter – PersonEntity: Name: NameFull: Knaevelsrud, Christine IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 08949867 Numbering: – Type: volume Value: 35 – Type: issue Value: 1 Titles: – TitleFull: Journal of Traumatic Stress Type: main |
| ResultId | 1 |
