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Completed suicide is associated with a higher polygenic burden for psychiatric disorders.

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Title: Completed suicide is associated with a higher polygenic burden for psychiatric disorders.
Authors: Mitjans, Marina (AUTHOR), Papiol, Sergi (AUTHOR), Barrot, Carme (AUTHOR), Guardiola-Ripoll, Maria (AUTHOR), Giménez-Palomo, Anna (AUTHOR), Gavín, Patricia (AUTHOR), Oraki Kohshour, Mojtaba (AUTHOR), Acosta, Miriam (AUTHOR), Pomarol-Clotet, Edith (AUTHOR), Castellà-García, Josep (AUTHOR), Pérez-Pérez, Rosa M. (AUTHOR), Gutiérrez, Blanca (AUTHOR), Schulze, Thomas G. (AUTHOR), Fatjó-Vilas, Mar (AUTHOR), Arias, Bárbara (AUTHOR), Benabarre, Antoni (AUTHOR)
Source: European Archives of Psychiatry & Clinical Neuroscience. Apr2022, Vol. 272 Issue 3, p355-358. 4p. 1 Graph.
Subjects: Mental illness, Suicide, Disease risk factors, Suicide victims, Hypomania, Suicide risk factors, Attempted suicide
Abstract: Polygenic Scores (PGS) were calculated using the imputation dosage for each risk allele based on the results of the following GWAS: SCZ [[8]], BD [[9]], MDD [[10]], and SA [[6]]. However, our positive results could derive not only from the proportion of individuals with a previous diagnosis of SCZ or BD in our sample of suicide completers but also from the shared genetic bases between SB and these psychiatric disorders. Keywords: Completed suicide; Polygenic risk score; Schizophrenia; Bipolar disorder; Major depressive disorder; Suicide attempt EN Completed suicide Polygenic risk score Schizophrenia Bipolar disorder Major depressive disorder Suicide attempt 355 358 4 03/24/22 20220401 NES 220401 Marina Mitjans and Sergi Papiol are co-first authors; Bárbara Arias and Antoni Benabarre are co-last authors. [Extracted from the article]
Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Completed suicide is associated with a higher polygenic burden for psychiatric disorders.
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  Data: <searchLink fieldCode="AR" term="%22Mitjans%2C+Marina%22">Mitjans, Marina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Papiol%2C+Sergi%22">Papiol, Sergi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Barrot%2C+Carme%22">Barrot, Carme</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guardiola-Ripoll%2C+Maria%22">Guardiola-Ripoll, Maria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Giménez-Palomo%2C+Anna%22">Giménez-Palomo, Anna</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gavín%2C+Patricia%22">Gavín, Patricia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Oraki+Kohshour%2C+Mojtaba%22">Oraki Kohshour, Mojtaba</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Acosta%2C+Miriam%22">Acosta, Miriam</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pomarol-Clotet%2C+Edith%22">Pomarol-Clotet, Edith</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Castellà-García%2C+Josep%22">Castellà-García, Josep</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pérez-Pérez%2C+Rosa+M%2E%22">Pérez-Pérez, Rosa M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gutiérrez%2C+Blanca%22">Gutiérrez, Blanca</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schulze%2C+Thomas+G%2E%22">Schulze, Thomas G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fatjó-Vilas%2C+Mar%22">Fatjó-Vilas, Mar</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Arias%2C+Bárbara%22">Arias, Bárbara</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Benabarre%2C+Antoni%22">Benabarre, Antoni</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Apr2022, Vol. 272 Issue 3, p355-358. 4p. 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Mental+illness%22">Mental illness</searchLink><br /><searchLink fieldCode="DE" term="%22Suicide%22">Suicide</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Suicide+victims%22">Suicide victims</searchLink><br /><searchLink fieldCode="DE" term="%22Hypomania%22">Hypomania</searchLink><br /><searchLink fieldCode="DE" term="%22Suicide+risk+factors%22">Suicide risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Attempted+suicide%22">Attempted suicide</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Polygenic Scores (PGS) were calculated using the imputation dosage for each risk allele based on the results of the following GWAS: SCZ [[8]], BD [[9]], MDD [[10]], and SA [[6]]. However, our positive results could derive not only from the proportion of individuals with a previous diagnosis of SCZ or BD in our sample of suicide completers but also from the shared genetic bases between SB and these psychiatric disorders. Keywords: Completed suicide; Polygenic risk score; Schizophrenia; Bipolar disorder; Major depressive disorder; Suicide attempt EN Completed suicide Polygenic risk score Schizophrenia Bipolar disorder Major depressive disorder Suicide attempt 355 358 4 03/24/22 20220401 NES 220401 Marina Mitjans and Sergi Papiol are co-first authors; Bárbara Arias and Antoni Benabarre are co-last authors. [Extracted from the article]
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  Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=155888665
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        Value: 10.1007/s00406-022-01398-5
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        Type: general
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      – TitleFull: Completed suicide is associated with a higher polygenic burden for psychiatric disorders.
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