Maintenance of multi-domain neurocognitive functions in patients with newly-diagnosed primary CNS lymphoma after primary cranial radiotherapy combined with methotrexate-based chemotherapy: A preliminary case-series study.
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| Title: | Maintenance of multi-domain neurocognitive functions in patients with newly-diagnosed primary CNS lymphoma after primary cranial radiotherapy combined with methotrexate-based chemotherapy: A preliminary case-series study. |
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| Authors: | Lin, Shinn-Yn (AUTHOR), Chuang, Chi-Cheng (AUTHOR), Tsan, Din-Li (AUTHOR), Hung, Yu-Shin (AUTHOR), Fu, Chen-Ju (AUTHOR), Shen, Yi-Liang (AUTHOR), Chiang, Yin-Yin (AUTHOR), Huang, Yin-Cheng (AUTHOR), Lu, Yu-Jen (AUTHOR), Yang, Chi-Cheng (AUTHOR) |
| Source: | Applied Neuropsychology: Adult. May/Jun2022, Vol. 29 Issue 3, p432-441. 10p. 4 Charts, 2 Graphs. |
| Abstract: | Conventional treatment for treating primary central nervous system lymphoma (PCNSL) has consisted of either whole-brain radiotherapy (WBRT) or methotrexate (MTX)-based combined modality therapy. However, delayed cognitive sequelae have emerged as a significant debilitating complication in PCNSL patients. A prospective observational case-series study with prospective assessments of neurocognitive functions (NCFs), neuroimaging, and activities of daily living in newly-diagnosed PCNSL patients was undertaken. A battery of neuropsychological measures, used to evaluate NCFs, is composed of ten standardized NCF tests, representing four domains sensitive to disease and treatment effects (executive function, attention, verbal memory, psychomotor speed), and activities of daily living. A total of 15 patients with newly-diagnosed PCNSL were consecutively enrolled in this study. Comparing the NCF scores between the baseline (before WBRT) and post-treatment (after combined chemoradiation therapy) intervals (Mean = 122.33 days, SD = 34.49, range = 77-196), neurobehavioral outcomes consistently remained improving or stable in almost each domain of NCF. Specifically, the scores on Paced Auditory Serial Addition Test-Revised (PASAT-R) were significantly improved between the baseline and post-chemoradiation assessment. Under the multidisciplinary treatment guidelines for treating patients with newly-diagnosed PCNSL, multi-domain NCF become stabilized and even improved after the course of conformal WBRT combined with or without MTX-based chemotherapy. [ABSTRACT FROM AUTHOR] |
| Copyright of Applied Neuropsychology: Adult is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 156029087 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Maintenance of multi-domain neurocognitive functions in patients with newly-diagnosed primary CNS lymphoma after primary cranial radiotherapy combined with methotrexate-based chemotherapy: A preliminary case-series study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Lin%2C+Shinn-Yn%22">Lin, Shinn-Yn</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chuang%2C+Chi-Cheng%22">Chuang, Chi-Cheng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tsan%2C+Din-Li%22">Tsan, Din-Li</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hung%2C+Yu-Shin%22">Hung, Yu-Shin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fu%2C+Chen-Ju%22">Fu, Chen-Ju</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shen%2C+Yi-Liang%22">Shen, Yi-Liang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chiang%2C+Yin-Yin%22">Chiang, Yin-Yin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huang%2C+Yin-Cheng%22">Huang, Yin-Cheng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lu%2C+Yu-Jen%22">Lu, Yu-Jen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Chi-Cheng%22">Yang, Chi-Cheng</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Applied+Neuropsychology%3A+Adult%22">Applied Neuropsychology: Adult</searchLink>. May/Jun2022, Vol. 29 Issue 3, p432-441. 10p. 4 Charts, 2 Graphs. – Name: Abstract Label: Abstract Group: Ab Data: Conventional treatment for treating primary central nervous system lymphoma (PCNSL) has consisted of either whole-brain radiotherapy (WBRT) or methotrexate (MTX)-based combined modality therapy. However, delayed cognitive sequelae have emerged as a significant debilitating complication in PCNSL patients. A prospective observational case-series study with prospective assessments of neurocognitive functions (NCFs), neuroimaging, and activities of daily living in newly-diagnosed PCNSL patients was undertaken. A battery of neuropsychological measures, used to evaluate NCFs, is composed of ten standardized NCF tests, representing four domains sensitive to disease and treatment effects (executive function, attention, verbal memory, psychomotor speed), and activities of daily living. A total of 15 patients with newly-diagnosed PCNSL were consecutively enrolled in this study. Comparing the NCF scores between the baseline (before WBRT) and post-treatment (after combined chemoradiation therapy) intervals (Mean = 122.33 days, SD = 34.49, range = 77-196), neurobehavioral outcomes consistently remained improving or stable in almost each domain of NCF. Specifically, the scores on Paced Auditory Serial Addition Test-Revised (PASAT-R) were significantly improved between the baseline and post-chemoradiation assessment. Under the multidisciplinary treatment guidelines for treating patients with newly-diagnosed PCNSL, multi-domain NCF become stabilized and even improved after the course of conformal WBRT combined with or without MTX-based chemotherapy. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Applied Neuropsychology: Adult is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/23279095.2020.1749630 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 432 Titles: – TitleFull: Maintenance of multi-domain neurocognitive functions in patients with newly-diagnosed primary CNS lymphoma after primary cranial radiotherapy combined with methotrexate-based chemotherapy: A preliminary case-series study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lin, Shinn-Yn – PersonEntity: Name: NameFull: Chuang, Chi-Cheng – PersonEntity: Name: NameFull: Tsan, Din-Li – PersonEntity: Name: NameFull: Hung, Yu-Shin – PersonEntity: Name: NameFull: Fu, Chen-Ju – PersonEntity: Name: NameFull: Shen, Yi-Liang – PersonEntity: Name: NameFull: Chiang, Yin-Yin – PersonEntity: Name: NameFull: Huang, Yin-Cheng – PersonEntity: Name: NameFull: Lu, Yu-Jen – PersonEntity: Name: NameFull: Yang, Chi-Cheng IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May/Jun2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 23279095 Numbering: – Type: volume Value: 29 – Type: issue Value: 3 Titles: – TitleFull: Applied Neuropsychology: Adult Type: main |
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