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Change in posttraumatic stress disorder-related thoughts during treatment: Do thoughts drive change when pills are involved?

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Title: Change in posttraumatic stress disorder-related thoughts during treatment: Do thoughts drive change when pills are involved?
Authors: Rauch, Sheila A.M. (AUTHOR), Kim, H. Myra (AUTHOR), Venners, Margaret R. (AUTHOR), Porter, Katherine E. (AUTHOR), Norman, Sonya B. (AUTHOR), Simon, Naomi M. (AUTHOR), Rothbaum, Barbara O. (AUTHOR), Tuerk, Peter W. (AUTHOR), Acierno, Ronald E. (AUTHOR), Bui, Eric (AUTHOR), Powell, Corey (AUTHOR), Smith, Erin R. (AUTHOR), Goetter, Elizabeth (AUTHOR), McSweeney, Lauren B. (AUTHOR)
Source: Journal of Traumatic Stress. Apr2022, Vol. 35 Issue 2, p496-507. 12p.
Subjects: Post-traumatic stress disorder, Sertraline, Psychological distress, Association of ideas, Change (Psychology), Veterans, Cognitive therapy, Drugs
Abstract: Posttraumatic negative thoughts about one's self and the world are related to posttraumatic stress disorder (PTSD) symptom severity and change in cognitive behavioral treatment (CBT), but little is known about this association when CBT is delivered with medication. The current study presents a planned comparison of changes in negative posttraumatic thoughts during (a) prolonged exposure (PE) plus pill placebo (PE+PLB), (b) sertraline plus enhanced medication management (SERT+EMM), and (c) PE plus sertraline (PE+SERT) as part of a randomized clinical trial in a sample of 176 veterans. Lagged regression modeling revealed that change in posttraumatic negative thoughts was associated with PTSD symptom change in the conditions in which participants received sertraline, ds = 0.14-0.25, ps = 0.04-.001). However, contrary to previous research, the models that started with symptom change were also statistically significant, d = 0.23, p < .001, for the lagged effect of symptoms on negative thoughts about self in the SERT+EMM condition, indicating a bidirectional association between such thoughts and PTSD symptoms. In the PE+PLB condition, no significant association between posttraumatic thoughts and PTSD symptoms emerged in either direction. These results suggest that the previously demonstrated role of change in posttraumatic thoughts leading to PTSD symptom reduction in PE may be altered when combined with pill administration, either active or placebo. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Traumatic Stress is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Change in posttraumatic stress disorder-related thoughts during treatment: Do thoughts drive change when pills are involved?
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rauch%2C+Sheila+A%2EM%2E%22&quot;&gt;Rauch, Sheila A.M.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kim%2C+H%2E+Myra%22&quot;&gt;Kim, H. Myra&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Venners%2C+Margaret+R%2E%22&quot;&gt;Venners, Margaret R.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Porter%2C+Katherine+E%2E%22&quot;&gt;Porter, Katherine E.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Norman%2C+Sonya+B%2E%22&quot;&gt;Norman, Sonya B.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Simon%2C+Naomi+M%2E%22&quot;&gt;Simon, Naomi M.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rothbaum%2C+Barbara+O%2E%22&quot;&gt;Rothbaum, Barbara O.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Tuerk%2C+Peter+W%2E%22&quot;&gt;Tuerk, Peter W.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Acierno%2C+Ronald+E%2E%22&quot;&gt;Acierno, Ronald E.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bui%2C+Eric%22&quot;&gt;Bui, Eric&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Powell%2C+Corey%22&quot;&gt;Powell, Corey&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Smith%2C+Erin+R%2E%22&quot;&gt;Smith, Erin R.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Goetter%2C+Elizabeth%22&quot;&gt;Goetter, Elizabeth&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22McSweeney%2C+Lauren+B%2E%22&quot;&gt;McSweeney, Lauren B.&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Journal+of+Traumatic+Stress%22&quot;&gt;Journal of Traumatic Stress&lt;/searchLink&gt;. Apr2022, Vol. 35 Issue 2, p496-507. 12p.
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  Data: Posttraumatic negative thoughts about one&#39;s self and the world are related to posttraumatic stress disorder (PTSD) symptom severity and change in cognitive behavioral treatment (CBT), but little is known about this association when CBT is delivered with medication. The current study presents a planned comparison of changes in negative posttraumatic thoughts during (a) prolonged exposure (PE) plus pill placebo (PE+PLB), (b) sertraline plus enhanced medication management (SERT+EMM), and (c) PE plus sertraline (PE+SERT) as part of a randomized clinical trial in a sample of 176 veterans. Lagged regression modeling revealed that change in posttraumatic negative thoughts was associated with PTSD symptom change in the conditions in which participants received sertraline, ds&#160;=&#160;0.14-0.25, ps&#160;=&#160;0.04-.001). However, contrary to previous research, the models that started with symptom change were also statistically significant, d&#160;=&#160;0.23, p&#160;&lt;&#160;.001, for the lagged effect of symptoms on negative thoughts about self in the SERT+EMM condition, indicating a bidirectional association between such thoughts and PTSD symptoms. In the PE+PLB condition, no significant association between posttraumatic thoughts and PTSD symptoms emerged in either direction. These results suggest that the previously demonstrated role of change in posttraumatic thoughts leading to PTSD symptom reduction in PE may be altered when combined with pill administration, either active or placebo. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Journal of Traumatic Stress is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=156397912
RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1002/jts.22762
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 12
        StartPage: 496
    Subjects:
      – SubjectFull: Post-traumatic stress disorder
        Type: general
      – SubjectFull: Sertraline
        Type: general
      – SubjectFull: Psychological distress
        Type: general
      – SubjectFull: Association of ideas
        Type: general
      – SubjectFull: Change (Psychology)
        Type: general
      – SubjectFull: Veterans
        Type: general
      – SubjectFull: Cognitive therapy
        Type: general
      – SubjectFull: Drugs
        Type: general
    Titles:
      – TitleFull: Change in posttraumatic stress disorder-related thoughts during treatment: Do thoughts drive change when pills are involved?
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            – D: 01
              M: 04
              Text: Apr2022
              Type: published
              Y: 2022
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