Blood–brain barrier dysfunction and myelin basic protein in survival of amyotrophic lateral sclerosis with or without frontotemporal dementia.
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| Title: | Blood–brain barrier dysfunction and myelin basic protein in survival of amyotrophic lateral sclerosis with or without frontotemporal dementia. |
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| Authors: | Li, Jin-Yue (AUTHOR), Cai, Zheng-Yi (AUTHOR), Sun, Xiao-Han (AUTHOR), Shen, Dong-chao (AUTHOR), Yang, Xun-Zhe (AUTHOR), Liu, Ming-Sheng (AUTHOR), Cui, Li-Ying (AUTHOR) |
| Source: | Neurological Sciences. May2022, Vol. 43 Issue 5, p3201-3210. 10p. 3 Charts, 2 Graphs. |
| Abstract: | Objective: We aim to investigate blood–brain barrier (BBB) dysfunction and myelin basic protein (MBP) in amyotrophic lateral sclerosis (ALS) with or without frontotemporal dementia (FTD) and further determine the effect of these factors on the survival of ALS. Methods: This was a retrospective study of 113 ALS patients, 12 ALS-FTD patients, and 40 disease controls hospitalized between September 2013 and October 2020. CSF parameters including total protein (TP), albumin (Alb), immunoglobulin-G (IgG), and MBP were collected and compared between groups. The CSF-TP, CSF-Alb, CSF-IgG, and CSF/serum quotients of Alb and IgG (QAlb, QIgG) were used to reflect the BBB status. Patients were followed up until December 2020. Cox regression and Kaplan–Meier method were used for survival analysis. Results: The CSF-TP, CSF-Alb, and CSF-IgG concentrations were significantly higher in patients than controls (p < 0.01). Increased CSF-TP and CSF-IgG was found in 45 (39.8%) and 27 (23.9%) ALS patients, while in 7 (58.3%) and 5 (41.7%) ALS-FTD patients. The level of CSF-Alb, CSF-IgG, and CSF-MBP were significantly higher in patients with ALS-FTD than ALS. MBP showed a moderate accuracy in the distinction between ALS-FTD and ALS (AUC = 0.715 ± 0.101). No difference in MBP was found between patients and controls. Kaplan–Meier analysis indicated that a higher CSF-TP, CSF-IgG, QIgG, or QAlb was significantly associated with shorter survival. Cox regression model showed that CSF-TP, CSF-IgG, and QIgG were independent predictors of survival. Conclusion: Our findings suggested that BBB dysfunction was more prominent in ALS-FTD than ALS and associated with a worse prognosis. Further studies are needed to determine the role of CSF-MBP as a biomarker in ALS. [ABSTRACT FROM AUTHOR] |
| Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 156399604 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Blood–brain barrier dysfunction and myelin basic protein in survival of amyotrophic lateral sclerosis with or without frontotemporal dementia. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Li%2C+Jin-Yue%22">Li, Jin-Yue</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cai%2C+Zheng-Yi%22">Cai, Zheng-Yi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sun%2C+Xiao-Han%22">Sun, Xiao-Han</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shen%2C+Dong-chao%22">Shen, Dong-chao</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Xun-Zhe%22">Yang, Xun-Zhe</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Ming-Sheng%22">Liu, Ming-Sheng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cui%2C+Li-Ying%22">Cui, Li-Ying</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. May2022, Vol. 43 Issue 5, p3201-3210. 10p. 3 Charts, 2 Graphs. – Name: Abstract Label: Abstract Group: Ab Data: Objective: We aim to investigate blood–brain barrier (BBB) dysfunction and myelin basic protein (MBP) in amyotrophic lateral sclerosis (ALS) with or without frontotemporal dementia (FTD) and further determine the effect of these factors on the survival of ALS. Methods: This was a retrospective study of 113 ALS patients, 12 ALS-FTD patients, and 40 disease controls hospitalized between September 2013 and October 2020. CSF parameters including total protein (TP), albumin (Alb), immunoglobulin-G (IgG), and MBP were collected and compared between groups. The CSF-TP, CSF-Alb, CSF-IgG, and CSF/serum quotients of Alb and IgG (QAlb, QIgG) were used to reflect the BBB status. Patients were followed up until December 2020. Cox regression and Kaplan–Meier method were used for survival analysis. Results: The CSF-TP, CSF-Alb, and CSF-IgG concentrations were significantly higher in patients than controls (p < 0.01). Increased CSF-TP and CSF-IgG was found in 45 (39.8%) and 27 (23.9%) ALS patients, while in 7 (58.3%) and 5 (41.7%) ALS-FTD patients. The level of CSF-Alb, CSF-IgG, and CSF-MBP were significantly higher in patients with ALS-FTD than ALS. MBP showed a moderate accuracy in the distinction between ALS-FTD and ALS (AUC = 0.715 ± 0.101). No difference in MBP was found between patients and controls. Kaplan–Meier analysis indicated that a higher CSF-TP, CSF-IgG, QIgG, or QAlb was significantly associated with shorter survival. Cox regression model showed that CSF-TP, CSF-IgG, and QIgG were independent predictors of survival. Conclusion: Our findings suggested that BBB dysfunction was more prominent in ALS-FTD than ALS and associated with a worse prognosis. Further studies are needed to determine the role of CSF-MBP as a biomarker in ALS. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10072-021-05731-z Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 3201 Titles: – TitleFull: Blood–brain barrier dysfunction and myelin basic protein in survival of amyotrophic lateral sclerosis with or without frontotemporal dementia. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Li, Jin-Yue – PersonEntity: Name: NameFull: Cai, Zheng-Yi – PersonEntity: Name: NameFull: Sun, Xiao-Han – PersonEntity: Name: NameFull: Shen, Dong-chao – PersonEntity: Name: NameFull: Yang, Xun-Zhe – PersonEntity: Name: NameFull: Liu, Ming-Sheng – PersonEntity: Name: NameFull: Cui, Li-Ying IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 15901874 Numbering: – Type: volume Value: 43 – Type: issue Value: 5 Titles: – TitleFull: Neurological Sciences Type: main |
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