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Abnormal connectivity model of raphe nuclei with sensory-associated cortex in Parkinson's disease with chronic pain.

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Title: Abnormal connectivity model of raphe nuclei with sensory-associated cortex in Parkinson's disease with chronic pain.
Authors: Shen, Yalian (AUTHOR), Wang, Juan (AUTHOR), Peng, Juan (AUTHOR), Wu, Xiaolin (AUTHOR), Chen, Xiaocui (AUTHOR), Liu, Jinjin (AUTHOR), Wei, Min (AUTHOR), Zou, Dezhi (AUTHOR), Han, Yu (AUTHOR), Wang, Anran (AUTHOR), Cheng, Oumei (AUTHOR)
Source: Neurological Sciences. May2022, Vol. 43 Issue 5, p3175-3185. 11p. 2 Color Photographs, 3 Charts, 1 Graph.
Subjects: Chronic pain, Parietal lobe, Neural pathways, Dopa, Magnetic resonance imaging, Brain mapping, Parkinson's disease, Brain stem, Disease complications
Abstract: Background and Objective: There are indicates that raphe nuclei may be involved in the occurrence of chronic pain in Parkinson's disease (PD). In the study, we investigated the functional connectivity pattern of raphe nuclei in Parkinson's disease with chronic pain (PDP) to uncover its possible pathophysiology.Methods: Fifteen PDP, who suffered from pain, lasted longer than 3 months, sixteen Parkinson's disease patients with no pain (nPDP) and eighteen matched normal health controls (NCs) were recruited. All subjects completed the King's Parkinson's Pain Scale (KPPS) besides Parkinson-related scale and demographics. We performed a seed-based resting-state analysis of functional magnetic resonance imaging to explore whole-brain functional connectivity of the raphe nuclei. Multiple regression model was used to explore the related factors of pain including disease duration, disease severity, Hamilton Depression Rating Scale, age, sex, levodopa equivalent dose and the strength of network functional connectivity.Results: Compared with the nPDP, the PDP group showed stronger functional connectivity between raphe nuclei and pain-related brain regions, including parietal lobe, insular lobe, cingulum cortex and prefrontal cortex, and the functional connectivity values of those areas were significantly positively correlated with KPPS independent of the clinical variables. Compared with NCs, the combined PD groups showed decreased functional connectivity including prefrontal cortex and cingulum cortex.Conclusions: Abnormal functional connectivity model of raphe nuclei may be partly involved in pathophysiological mechanism of pain in PD. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Abnormal connectivity model of raphe nuclei with sensory-associated cortex in Parkinson's disease with chronic pain.
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  Data: <searchLink fieldCode="AR" term="%22Shen%2C+Yalian%22">Shen, Yalian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Juan%22">Wang, Juan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Peng%2C+Juan%22">Peng, Juan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wu%2C+Xiaolin%22">Wu, Xiaolin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Xiaocui%22">Chen, Xiaocui</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Jinjin%22">Liu, Jinjin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wei%2C+Min%22">Wei, Min</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zou%2C+Dezhi%22">Zou, Dezhi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Han%2C+Yu%22">Han, Yu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Anran%22">Wang, Anran</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cheng%2C+Oumei%22">Cheng, Oumei</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. May2022, Vol. 43 Issue 5, p3175-3185. 11p. 2 Color Photographs, 3 Charts, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Chronic+pain%22">Chronic pain</searchLink><br /><searchLink fieldCode="DE" term="%22Parietal+lobe%22">Parietal lobe</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+pathways%22">Neural pathways</searchLink><br /><searchLink fieldCode="DE" term="%22Dopa%22">Dopa</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+mapping%22">Brain mapping</searchLink><br /><searchLink fieldCode="DE" term="%22Parkinson's+disease%22">Parkinson's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+stem%22">Brain stem</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+complications%22">Disease complications</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: <bold>Background and Objective: </bold>There are indicates that raphe nuclei may be involved in the occurrence of chronic pain in Parkinson's disease (PD). In the study, we investigated the functional connectivity pattern of raphe nuclei in Parkinson's disease with chronic pain (PDP) to uncover its possible pathophysiology.<bold>Methods: </bold>Fifteen PDP, who suffered from pain, lasted longer than 3 months, sixteen Parkinson's disease patients with no pain (nPDP) and eighteen matched normal health controls (NCs) were recruited. All subjects completed the King's Parkinson's Pain Scale (KPPS) besides Parkinson-related scale and demographics. We performed a seed-based resting-state analysis of functional magnetic resonance imaging to explore whole-brain functional connectivity of the raphe nuclei. Multiple regression model was used to explore the related factors of pain including disease duration, disease severity, Hamilton Depression Rating Scale, age, sex, levodopa equivalent dose and the strength of network functional connectivity.<bold>Results: </bold>Compared with the nPDP, the PDP group showed stronger functional connectivity between raphe nuclei and pain-related brain regions, including parietal lobe, insular lobe, cingulum cortex and prefrontal cortex, and the functional connectivity values of those areas were significantly positively correlated with KPPS independent of the clinical variables. Compared with NCs, the combined PD groups showed decreased functional connectivity including prefrontal cortex and cingulum cortex.<bold>Conclusions: </bold>Abnormal functional connectivity model of raphe nuclei may be partly involved in pathophysiological mechanism of pain in PD. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10072-022-05864-9
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