Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators.
Saved in:
| Title: | Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators. |
|---|---|
| Authors: | Wu, Zhaofa (AUTHOR), Lin, Dayu (AUTHOR), Li, Yulong (AUTHOR) |
| Source: | Nature Reviews Neuroscience. May2022, Vol. 23 Issue 5, p257-274. 18p. |
| Subjects: | Neurotransmitters, Drugs |
| Abstract: | Neurotransmitters and neuromodulators have a wide range of key roles throughout the nervous system. However, their dynamics in both health and disease have been challenging to assess, owing to the lack of in vivo tools to track them with high spatiotemporal resolution. Thus, developing a platform that enables minimally invasive, large-scale and long-term monitoring of neurotransmitters and neuromodulators with high sensitivity, high molecular specificity and high spatiotemporal resolution has been essential. Here, we review the methods available for monitoring the dynamics of neurotransmitters and neuromodulators. Following a brief summary of non-genetically encoded methods, we focus on recent developments in genetically encoded fluorescent indicators, highlighting how these novel indicators have facilitated advances in our understanding of the functional roles of neurotransmitters and neuromodulators in the nervous system. These studies present a promising outlook for the future development and use of tools to monitor neurotransmitters and neuromodulators. [ABSTRACT FROM AUTHOR] |
| Copyright of Nature Reviews Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 156495083 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Wu%2C+Zhaofa%22">Wu, Zhaofa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lin%2C+Dayu%22">Lin, Dayu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Yulong%22">Li, Yulong</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nature+Reviews+Neuroscience%22">Nature Reviews Neuroscience</searchLink>. May2022, Vol. 23 Issue 5, p257-274. 18p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Neurotransmitters%22">Neurotransmitters</searchLink><br /><searchLink fieldCode="DE" term="%22Drugs%22">Drugs</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Neurotransmitters and neuromodulators have a wide range of key roles throughout the nervous system. However, their dynamics in both health and disease have been challenging to assess, owing to the lack of in vivo tools to track them with high spatiotemporal resolution. Thus, developing a platform that enables minimally invasive, large-scale and long-term monitoring of neurotransmitters and neuromodulators with high sensitivity, high molecular specificity and high spatiotemporal resolution has been essential. Here, we review the methods available for monitoring the dynamics of neurotransmitters and neuromodulators. Following a brief summary of non-genetically encoded methods, we focus on recent developments in genetically encoded fluorescent indicators, highlighting how these novel indicators have facilitated advances in our understanding of the functional roles of neurotransmitters and neuromodulators in the nervous system. These studies present a promising outlook for the future development and use of tools to monitor neurotransmitters and neuromodulators. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nature Reviews Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=156495083 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41583-022-00577-6 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 18 StartPage: 257 Subjects: – SubjectFull: Neurotransmitters Type: general – SubjectFull: Drugs Type: general Titles: – TitleFull: Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Wu, Zhaofa – PersonEntity: Name: NameFull: Lin, Dayu – PersonEntity: Name: NameFull: Li, Yulong IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 1471003X Numbering: – Type: volume Value: 23 – Type: issue Value: 5 Titles: – TitleFull: Nature Reviews Neuroscience Type: main |
| ResultId | 1 |
