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Stepwise-edited, human melanoma models reveal mutations’ effect on tumor and microenvironment.

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Title: Stepwise-edited, human melanoma models reveal mutations’ effect on tumor and microenvironment.
Authors: Hodis, Eran, Triglia, Elena Torlai, Kwon, John Y. H., Biancalani, Tommaso, Zakka, Labib R., Parkar, Saurabh, Hütter, Jan-Christian, Buffoni, Lorenzo, Delorey, Toni M., Phillips, Devan, Dionne, Danielle, Nguyen, Lan T., Schapiro, Denis, Maliga, Zoltan, Jacobson, Connor A., Hendel, Ayal, Rozenblatt-Rosen, Orit, Mihm, Martin C. Jr., Garraway, Levi A., Regev, Aviv
Source: Science (pre-March 2025). 4/29/2022, Vol. 376 Issue 6592, p474-474. 1p. 1 Diagram.
Subjects: Cancer, Investigational therapies, Genomes, Phenotypes, Experimental design
Abstract: The article presents the discussion on understanding of the mechanisms of cancer pathogenesis and genetically linked disease features. Topics include specific genetic alterations in particular cancer types being linked to prognosis in response or resistance to therapies; and genome-edited models replicating the precise genetics, lineage relationships and stepwise progression of cancer and establishing genotype-to-phenotype links in a controlled experimental design.
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Stepwise-edited, human melanoma models reveal mutations’ effect on tumor and microenvironment.
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  Data: <searchLink fieldCode="AR" term="%22Hodis%2C+Eran%22">Hodis, Eran</searchLink><br /><searchLink fieldCode="AR" term="%22Triglia%2C+Elena+Torlai%22">Triglia, Elena Torlai</searchLink><br /><searchLink fieldCode="AR" term="%22Kwon%2C+John+Y%2E+H%2E%22">Kwon, John Y. H.</searchLink><br /><searchLink fieldCode="AR" term="%22Biancalani%2C+Tommaso%22">Biancalani, Tommaso</searchLink><br /><searchLink fieldCode="AR" term="%22Zakka%2C+Labib+R%2E%22">Zakka, Labib R.</searchLink><br /><searchLink fieldCode="AR" term="%22Parkar%2C+Saurabh%22">Parkar, Saurabh</searchLink><br /><searchLink fieldCode="AR" term="%22Hütter%2C+Jan-Christian%22">Hütter, Jan-Christian</searchLink><br /><searchLink fieldCode="AR" term="%22Buffoni%2C+Lorenzo%22">Buffoni, Lorenzo</searchLink><br /><searchLink fieldCode="AR" term="%22Delorey%2C+Toni+M%2E%22">Delorey, Toni M.</searchLink><br /><searchLink fieldCode="AR" term="%22Phillips%2C+Devan%22">Phillips, Devan</searchLink><br /><searchLink fieldCode="AR" term="%22Dionne%2C+Danielle%22">Dionne, Danielle</searchLink><br /><searchLink fieldCode="AR" term="%22Nguyen%2C+Lan+T%2E%22">Nguyen, Lan T.</searchLink><br /><searchLink fieldCode="AR" term="%22Schapiro%2C+Denis%22">Schapiro, Denis</searchLink><br /><searchLink fieldCode="AR" term="%22Maliga%2C+Zoltan%22">Maliga, Zoltan</searchLink><br /><searchLink fieldCode="AR" term="%22Jacobson%2C+Connor+A%2E%22">Jacobson, Connor A.</searchLink><br /><searchLink fieldCode="AR" term="%22Hendel%2C+Ayal%22">Hendel, Ayal</searchLink><br /><searchLink fieldCode="AR" term="%22Rozenblatt-Rosen%2C+Orit%22">Rozenblatt-Rosen, Orit</searchLink><br /><searchLink fieldCode="AR" term="%22Mihm%2C+Martin+C%2E+Jr%2E%22">Mihm, Martin C. Jr.</searchLink><br /><searchLink fieldCode="AR" term="%22Garraway%2C+Levi+A%2E%22">Garraway, Levi A.</searchLink><br /><searchLink fieldCode="AR" term="%22Regev%2C+Aviv%22">Regev, Aviv</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 4/29/2022, Vol. 376 Issue 6592, p474-474. 1p. 1 Diagram.
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  Data: <searchLink fieldCode="DE" term="%22Cancer%22">Cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Investigational+therapies%22">Investigational therapies</searchLink><br /><searchLink fieldCode="DE" term="%22Genomes%22">Genomes</searchLink><br /><searchLink fieldCode="DE" term="%22Phenotypes%22">Phenotypes</searchLink><br /><searchLink fieldCode="DE" term="%22Experimental+design%22">Experimental design</searchLink>
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  Data: The article presents the discussion on understanding of the mechanisms of cancer pathogenesis and genetically linked disease features. Topics include specific genetic alterations in particular cancer types being linked to prognosis in response or resistance to therapies; and genome-edited models replicating the precise genetics, lineage relationships and stepwise progression of cancer and establishing genotype-to-phenotype links in a controlled experimental design.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=156564366
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        Value: 10.1126/science.abi8175
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        Text: English
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      – TitleFull: Stepwise-edited, human melanoma models reveal mutations’ effect on tumor and microenvironment.
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              Text: 4/29/2022
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              Y: 2022
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