Brain grey matter perfusion in primary progressive multiple sclerosis: Mild decrease over years and regional associations with cognition and hand function.
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| Title: | Brain grey matter perfusion in primary progressive multiple sclerosis: Mild decrease over years and regional associations with cognition and hand function. |
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| Authors: | Testud, Benoit (AUTHOR), Delacour, Clara (AUTHOR), El Ahmadi, Ahmed Ali (AUTHOR), Brun, Gilles (AUTHOR), Girard, Nadine (AUTHOR), Duhamel, Guillaume (AUTHOR), Heesen, Christoph (AUTHOR), Häußler, Vivien (AUTHOR), Thaler, Christian (AUTHOR), Has Silemek, Arzu Ceylan (AUTHOR), Stellmann, Jan‐Patrick (AUTHOR) |
| Source: | European Journal of Neurology. Jun2022, Vol. 29 Issue 6, p1741-1752. 12p. |
| Subjects: | Multiple sclerosis, Perfusion, Cerebral circulation, Magnetic resonance imaging, Isolation perfusion |
| Abstract: | Background and purpose: Extent and dynamic of neurodegeneration in progressive multiple sclerosis (MS) might be reflected by global and regional brain perfusion, an outcome at the intercept between structure and function. Here, we provide a first insight into the evolution of brain perfusion and its association with disability in primary progressive MS (PPMS) over several years. Methods: Seventy‐seven persons with PPMS were followed over up to 5 years. Visits included a 3‐T magnetic resonance imaging with pulsed arterial spin labelling perfusion, the Timed 25‐Foot Walk, 9‐Hole Peg Test (NHPT), Symbol Digit Modalities Test (SDMT), and Expanded Disability Status Scale (EDSS). We extracted regional cerebral blood flow surrogates and compared them to 11 controls. Analyses focused on cortical and deep grey matter, the change over time, and associations with disability on the regional and global levels. Results: Baseline brain perfusion of patients and controls was comparable for the cortex (p = 0.716) and deep grey matter (p = 0.095). EDSS disability increased mildly (p = 0.023), whereas brain perfusion decreased during follow‐up (p < 0.001) and with disease duration (p = 0.009). Lower global perfusion correlated with higher disability as indicated by EDSS, NHPT, and Timed 25‐Foot Walk (p < 0.001). The motor task NHPT showed associations with 20 grey matter regions. In contrast, better SDMT performance correlated with lower perfusion (p < 0.001) in seven predominantly frontal regions, indicating a functional maladaptation. Conclusions: Decreasing perfusion indicates a putative association with MS disease mechanisms such as neurodegeneration, reduced metabolism, and loss of resilience. A low alteration rate limits its use in clinical practice, but regional association patterns might provide a snapshot of adaptive and maladaptive functional reorganization. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 156736714 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Brain grey matter perfusion in primary progressive multiple sclerosis: Mild decrease over years and regional associations with cognition and hand function. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Testud%2C+Benoit%22">Testud, Benoit</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Delacour%2C+Clara%22">Delacour, Clara</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22El+Ahmadi%2C+Ahmed+Ali%22">El Ahmadi, Ahmed Ali</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Brun%2C+Gilles%22">Brun, Gilles</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Girard%2C+Nadine%22">Girard, Nadine</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Duhamel%2C+Guillaume%22">Duhamel, Guillaume</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Heesen%2C+Christoph%22">Heesen, Christoph</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Häußler%2C+Vivien%22">Häußler, Vivien</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Thaler%2C+Christian%22">Thaler, Christian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Has+Silemek%2C+Arzu+Ceylan%22">Has Silemek, Arzu Ceylan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stellmann%2C+Jan‐Patrick%22">Stellmann, Jan‐Patrick</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Jun2022, Vol. 29 Issue 6, p1741-1752. 12p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Multiple+sclerosis%22">Multiple sclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22Perfusion%22">Perfusion</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+circulation%22">Cerebral circulation</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Isolation+perfusion%22">Isolation perfusion</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background and purpose: Extent and dynamic of neurodegeneration in progressive multiple sclerosis (MS) might be reflected by global and regional brain perfusion, an outcome at the intercept between structure and function. Here, we provide a first insight into the evolution of brain perfusion and its association with disability in primary progressive MS (PPMS) over several years. Methods: Seventy‐seven persons with PPMS were followed over up to 5 years. Visits included a 3‐T magnetic resonance imaging with pulsed arterial spin labelling perfusion, the Timed 25‐Foot Walk, 9‐Hole Peg Test (NHPT), Symbol Digit Modalities Test (SDMT), and Expanded Disability Status Scale (EDSS). We extracted regional cerebral blood flow surrogates and compared them to 11 controls. Analyses focused on cortical and deep grey matter, the change over time, and associations with disability on the regional and global levels. Results: Baseline brain perfusion of patients and controls was comparable for the cortex (p = 0.716) and deep grey matter (p = 0.095). EDSS disability increased mildly (p = 0.023), whereas brain perfusion decreased during follow‐up (p < 0.001) and with disease duration (p = 0.009). Lower global perfusion correlated with higher disability as indicated by EDSS, NHPT, and Timed 25‐Foot Walk (p < 0.001). The motor task NHPT showed associations with 20 grey matter regions. In contrast, better SDMT performance correlated with lower perfusion (p < 0.001) in seven predominantly frontal regions, indicating a functional maladaptation. Conclusions: Decreasing perfusion indicates a putative association with MS disease mechanisms such as neurodegeneration, reduced metabolism, and loss of resilience. A low alteration rate limits its use in clinical practice, but regional association patterns might provide a snapshot of adaptive and maladaptive functional reorganization. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/ene.15289 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 1741 Subjects: – SubjectFull: Multiple sclerosis Type: general – SubjectFull: Perfusion Type: general – SubjectFull: Cerebral circulation Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Isolation perfusion Type: general Titles: – TitleFull: Brain grey matter perfusion in primary progressive multiple sclerosis: Mild decrease over years and regional associations with cognition and hand function. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Testud, Benoit – PersonEntity: Name: NameFull: Delacour, Clara – PersonEntity: Name: NameFull: El Ahmadi, Ahmed Ali – PersonEntity: Name: NameFull: Brun, Gilles – PersonEntity: Name: NameFull: Girard, Nadine – PersonEntity: Name: NameFull: Duhamel, Guillaume – PersonEntity: Name: NameFull: Heesen, Christoph – PersonEntity: Name: NameFull: Häußler, Vivien – PersonEntity: Name: NameFull: Thaler, Christian – PersonEntity: Name: NameFull: Has Silemek, Arzu Ceylan – PersonEntity: Name: NameFull: Stellmann, Jan‐Patrick IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 13515101 Numbering: – Type: volume Value: 29 – Type: issue Value: 6 Titles: – TitleFull: European Journal of Neurology Type: main |
| ResultId | 1 |
