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Efficacy and safety of intravenous high-dose immunoglobulin in treatment of the severe form of Japanese encephalitis.

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Title: Efficacy and safety of intravenous high-dose immunoglobulin in treatment of the severe form of Japanese encephalitis.
Authors: Chen, Dan (AUTHOR), Peng, Xiaoling (AUTHOR), Zhan, Yu (AUTHOR), Wu, Peng (AUTHOR), Jiang, Li (AUTHOR), Hu, Yue (AUTHOR)
Source: Neurological Sciences. Jun2022, Vol. 43 Issue 6, p3911-3918. 8p. 4 Charts, 1 Graph.
Subjects: Japanese B encephalitis, Intravenous immunoglobulins, Gastrointestinal hemorrhage, Survival analysis (Biometry), Regression analysis, Mucocutaneous lymph node syndrome, Intravenous therapy, Epidemic encephalitis, Retrospective studies, Treatment effectiveness
Abstract: Purpose: To explore the efficacy and safety of intravenous immunoglobulin (IVIG) in the treatment of severe Japanese encephalitis (JE).Methods: A retrospective study of 124 children diagnosed with the severe or very severe form of JE was undertaken. There were 62 cases in the IVIG group and control group. The efficacy, safety, and tolerability of IVIG were evaluated 3 days, as well as 1, 2, and 3 weeks after IVIG, respectively, and the prognosis was assessed at 6 months.Results: Cox regression survival analysis suggested that the IVIG group reached the criteria for efficacious treatment faster than that in the control group. The duration of unconsciousness and the number of days of seizures, a dull response to light, the pyramidal sign, and meningeal-irritation sign in the IVIG group were shorter than those in the control group (p < 0.05). The number of complications occurring in the IVIG group (including gastrointestinal bleeding and pneumonia) was less than that in the control group (p < 0.05). Cox regression survival analysis suggested that age (p = 0.003) and imaging abnormalities (p = 0.042) had an effect on the efficacy of IVIG treatment. The Liverpool Outcome Score at 6 months showed that the prognosis of the IVIG group was better than that of the control group (p < 0.05). IVIG treatment was safe and tolerable.Conclusion: IVIG showed good efficacy, safety, and tolerance for treatment of the severe form of JE. The age and imaging abnormalities of patients affect the efficacy of IVIG treatment. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Efficacy and safety of intravenous high-dose immunoglobulin in treatment of the severe form of Japanese encephalitis.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Chen%2C+Dan%22&quot;&gt;Chen, Dan&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Peng%2C+Xiaoling%22&quot;&gt;Peng, Xiaoling&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zhan%2C+Yu%22&quot;&gt;Zhan, Yu&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wu%2C+Peng%22&quot;&gt;Wu, Peng&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Jiang%2C+Li%22&quot;&gt;Jiang, Li&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hu%2C+Yue%22&quot;&gt;Hu, Yue&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Neurological+Sciences%22&quot;&gt;Neurological Sciences&lt;/searchLink&gt;. Jun2022, Vol. 43 Issue 6, p3911-3918. 8p. 4 Charts, 1 Graph.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Japanese+B+encephalitis%22&quot;&gt;Japanese B encephalitis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Intravenous+immunoglobulins%22&quot;&gt;Intravenous immunoglobulins&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Gastrointestinal+hemorrhage%22&quot;&gt;Gastrointestinal hemorrhage&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Survival+analysis+%28Biometry%29%22&quot;&gt;Survival analysis (Biometry)&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Regression+analysis%22&quot;&gt;Regression analysis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Mucocutaneous+lymph+node+syndrome%22&quot;&gt;Mucocutaneous lymph node syndrome&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Intravenous+therapy%22&quot;&gt;Intravenous therapy&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Epidemic+encephalitis%22&quot;&gt;Epidemic encephalitis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Retrospective+studies%22&quot;&gt;Retrospective studies&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Treatment+effectiveness%22&quot;&gt;Treatment effectiveness&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: &lt;bold&gt;Purpose: &lt;/bold&gt;To explore the efficacy and safety of intravenous immunoglobulin (IVIG) in the treatment of severe Japanese encephalitis (JE).&lt;bold&gt;Methods: &lt;/bold&gt;A retrospective study of 124 children diagnosed with the severe or very severe form of JE was undertaken. There were 62 cases in the IVIG group and control group. The efficacy, safety, and tolerability of IVIG were evaluated 3&#160;days, as well as 1, 2, and 3&#160;weeks after IVIG, respectively, and the prognosis was assessed at 6&#160;months.&lt;bold&gt;Results: &lt;/bold&gt;Cox regression survival analysis suggested that the IVIG group reached the criteria for efficacious treatment faster than that in the control group. The duration of unconsciousness and the number of days of seizures, a dull response to light, the pyramidal sign, and meningeal-irritation sign in the IVIG group were shorter than those in the control group (p &lt; 0.05). The number of complications occurring in the IVIG group (including gastrointestinal bleeding and pneumonia) was less than that in the control group (p &lt; 0.05). Cox regression survival analysis suggested that age (p = 0.003) and imaging abnormalities (p = 0.042) had an effect on the efficacy of IVIG treatment. The Liverpool Outcome Score at 6&#160;months showed that the prognosis of the IVIG group was better than that of the control group (p &lt; 0.05). IVIG treatment was safe and tolerable.&lt;bold&gt;Conclusion: &lt;/bold&gt;IVIG showed good efficacy, safety, and tolerance for treatment of the severe form of JE. The age and imaging abnormalities of patients affect the efficacy of IVIG treatment. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10072-022-05891-6
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      – Code: eng
        Text: English
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        StartPage: 3911
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      – SubjectFull: Japanese B encephalitis
        Type: general
      – SubjectFull: Intravenous immunoglobulins
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      – SubjectFull: Gastrointestinal hemorrhage
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      – SubjectFull: Mucocutaneous lymph node syndrome
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              Text: Jun2022
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