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Sex differences in the relationship of sleep-disordered breathing and asthma control among children with severe asthma.

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Title: Sex differences in the relationship of sleep-disordered breathing and asthma control among children with severe asthma.
Authors: Gunnlaugsson, Sigfus (AUTHOR), Greco, Kimberly F. (AUTHOR), Petty, Carter R. (AUTHOR), Sierra, Gabriella C. (AUTHOR), Stamatiadis, Natalie P. (AUTHOR), Thayer, Christine (AUTHOR), Hammond, Adam G. (AUTHOR), Giancola, Lauren M. (NURSE), Katwa, Umakanth (AUTHOR), Simoneau, Tregony (AUTHOR), Baxi, Sachin N. (AUTHOR), Gaffin, Jonathan M. (AUTHOR)
Source: Journal of Asthma. Jun2022, Vol. 59 Issue 6, p1148-1156. 9p.
Subjects: Asthma in children, Sleep apnea syndromes, Asthma, Children's hospitals, Wheeze
Abstract: Children with severe asthma are underrepresented in studies of the relationship of sleep-disordered breathing (SDB) and asthma and little is known about sex differences of these relationships. We sought to determine the relationship of SDB with asthma control and lung function among boys and girls within a pediatric severe asthma cohort. Patients attending clinic visits at the Boston Children's Hospital Pediatric Severe Asthma Program completed the Pediatric Sleep Questionnaire (PSQ), Asthma Control Test (ACT) and Spirometry. The prevalence of SDB was defined as a PSQ score >0.33. We analyzed the association between PSQ score and both ACT score and spirometry values in mixed effect models, testing interactions for age and sex. Among 37 subjects, mean age was 11.8 years (4.4) and 23 (62.2%) were male, the prevalence of SDB was 43.2% (16/37). Including all 80 observations, there was a moderate negative correlation between PSQ and ACT scores (r=-0.46, p < 0.001). Multivariable linear regression models revealed a significant sex interaction with PSQ on asthma control (p = 0.003), such that for each 0.10 point increase in PSQ there was a 1.88 point decrease in ACT score for females but only 0.21 point decrease in ACT score for males. A positive PSQ screen was associated with a 9.44 point (CI 5.54, 13.34, p < 0.001) lower ACT score for females and a 3.22 point (CI 0.56, 5.88, p = 0.02) lower score for males. SDB is common among children with severe asthma. Among children with severe asthma, SDB in girls portends to significantly worse asthma control than boys. Supplemental data for this article is available online at . [ABSTRACT FROM AUTHOR]
Copyright of Journal of Asthma is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Sex differences in the relationship of sleep-disordered breathing and asthma control among children with severe asthma.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gunnlaugsson%2C+Sigfus%22&quot;&gt;Gunnlaugsson, Sigfus&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Greco%2C+Kimberly+F%2E%22&quot;&gt;Greco, Kimberly F.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Petty%2C+Carter+R%2E%22&quot;&gt;Petty, Carter R.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Sierra%2C+Gabriella+C%2E%22&quot;&gt;Sierra, Gabriella C.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Stamatiadis%2C+Natalie+P%2E%22&quot;&gt;Stamatiadis, Natalie P.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Thayer%2C+Christine%22&quot;&gt;Thayer, Christine&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hammond%2C+Adam+G%2E%22&quot;&gt;Hammond, Adam G.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Giancola%2C+Lauren+M%2E%22&quot;&gt;Giancola, Lauren M.&lt;/searchLink&gt; (NURSE)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Katwa%2C+Umakanth%22&quot;&gt;Katwa, Umakanth&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Simoneau%2C+Tregony%22&quot;&gt;Simoneau, Tregony&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Baxi%2C+Sachin+N%2E%22&quot;&gt;Baxi, Sachin N.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gaffin%2C+Jonathan+M%2E%22&quot;&gt;Gaffin, Jonathan M.&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Journal+of+Asthma%22&quot;&gt;Journal of Asthma&lt;/searchLink&gt;. Jun2022, Vol. 59 Issue 6, p1148-1156. 9p.
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  Data: Children with severe asthma are underrepresented in studies of the relationship of sleep-disordered breathing (SDB) and asthma and little is known about sex differences of these relationships. We sought to determine the relationship of SDB with asthma control and lung function among boys and girls within a pediatric severe asthma cohort. Patients attending clinic visits at the Boston Children&#39;s Hospital Pediatric Severe Asthma Program completed the Pediatric Sleep Questionnaire (PSQ), Asthma Control Test (ACT) and Spirometry. The prevalence of SDB was defined as a PSQ score &gt;0.33. We analyzed the association between PSQ score and both ACT score and spirometry values in mixed effect models, testing interactions for age and sex. Among 37 subjects, mean age was 11.8 years (4.4) and 23 (62.2%) were male, the prevalence of SDB was 43.2% (16/37). Including all 80 observations, there was a moderate negative correlation between PSQ and ACT scores (r=-0.46, p &lt; 0.001). Multivariable linear regression models revealed a significant sex interaction with PSQ on asthma control (p = 0.003), such that for each 0.10 point increase in PSQ there was a 1.88 point decrease in ACT score for females but only 0.21 point decrease in ACT score for males. A positive PSQ screen was associated with a 9.44 point (CI 5.54, 13.34, p &lt; 0.001) lower ACT score for females and a 3.22 point (CI 0.56, 5.88, p = 0.02) lower score for males. SDB is common among children with severe asthma. Among children with severe asthma, SDB in girls portends to significantly worse asthma control than boys. Supplemental data for this article is available online at . [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: &lt;i&gt;Copyright of Journal of Asthma is the property of Taylor &amp; Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1080/02770903.2021.1897838
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        Text: English
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        PageCount: 9
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      – SubjectFull: Asthma in children
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              Text: Jun2022
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