Using DNA to predict behaviour problems from preschool to adulthood.
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| Title: | Using DNA to predict behaviour problems from preschool to adulthood. |
|---|---|
| Authors: | Gidziela, Agnieszka, Rimfeld, Kaili, Malanchini, Margherita, Allegrini, Andrea G., McMillan, Andrew, Selzam, Saskia, Ronald, Angelica, Viding, Essi, von Stumm, Sophie, Eley, Thalia C., Plomin, Robert |
| Source: | Journal of Child Psychology & Psychiatry. Jul2022, Vol. 63 Issue 7, p781-792. 12p. 1 Diagram, 4 Graphs. |
| Subjects: | DNA, Transition to adulthood, Descriptive statistics |
| Abstract: | Background: One goal of the DNA revolution is to predict problems in order to prevent them. We tested here if the prediction of behaviour problems from genome‐wide polygenic scores (GPS) can be improved by creating composites across ages and across raters and by using a multi‐GPS approach that includes GPS for adult psychiatric disorders as well as for childhood behaviour problems. Method: Our sample included 3,065 genotyped unrelated individuals from the Twins Early Development Study who were assessed longitudinally for hyperactivity, conduct, emotional problems, and peer problems as rated by parents, teachers, and children themselves. GPS created from 15 genome‐wide association studies were used separately and jointly to test the prediction of behaviour problems composites (general behaviour problems, externalising, and internalising) across ages (from age 2 to 21) and across raters in penalised regression models. Based on the regression weights, we created multi‐trait GPS reflecting the best prediction of behaviour problems. We compared GPS prediction to twin heritability using the same sample and measures. Results: Multi‐GPS prediction of behaviour problems increased from <2% of the variance for observed traits to up to 6% for cross‐age and cross‐rater composites. Twin study estimates of heritability, although to a lesser extent, mirrored patterns of multi‐GPS prediction as they increased from <40% to 83%. Conclusions: The ability of GPS to predict behaviour problems can be improved by using multiple GPS, cross‐age composites and cross‐rater composites, although the effect sizes remain modest, up to 6%. Our approach can be used in any genotyped sample to create multi‐trait GPS predictors of behaviour problems that will be more predictive than polygenic scores based on a single age, rater, or GPS. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Child Psychology & Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 157276009 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Using DNA to predict behaviour problems from preschool to adulthood. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Gidziela%2C+Agnieszka%22">Gidziela, Agnieszka</searchLink><br /><searchLink fieldCode="AR" term="%22Rimfeld%2C+Kaili%22">Rimfeld, Kaili</searchLink><br /><searchLink fieldCode="AR" term="%22Malanchini%2C+Margherita%22">Malanchini, Margherita</searchLink><br /><searchLink fieldCode="AR" term="%22Allegrini%2C+Andrea+G%2E%22">Allegrini, Andrea G.</searchLink><br /><searchLink fieldCode="AR" term="%22McMillan%2C+Andrew%22">McMillan, Andrew</searchLink><br /><searchLink fieldCode="AR" term="%22Selzam%2C+Saskia%22">Selzam, Saskia</searchLink><br /><searchLink fieldCode="AR" term="%22Ronald%2C+Angelica%22">Ronald, Angelica</searchLink><br /><searchLink fieldCode="AR" term="%22Viding%2C+Essi%22">Viding, Essi</searchLink><br /><searchLink fieldCode="AR" term="%22von+Stumm%2C+Sophie%22">von Stumm, Sophie</searchLink><br /><searchLink fieldCode="AR" term="%22Eley%2C+Thalia+C%2E%22">Eley, Thalia C.</searchLink><br /><searchLink fieldCode="AR" term="%22Plomin%2C+Robert%22">Plomin, Robert</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Child+Psychology+%26+Psychiatry%22">Journal of Child Psychology & Psychiatry</searchLink>. Jul2022, Vol. 63 Issue 7, p781-792. 12p. 1 Diagram, 4 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22DNA%22">DNA</searchLink><br /><searchLink fieldCode="DE" term="%22Transition+to+adulthood%22">Transition to adulthood</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: One goal of the DNA revolution is to predict problems in order to prevent them. We tested here if the prediction of behaviour problems from genome‐wide polygenic scores (GPS) can be improved by creating composites across ages and across raters and by using a multi‐GPS approach that includes GPS for adult psychiatric disorders as well as for childhood behaviour problems. Method: Our sample included 3,065 genotyped unrelated individuals from the Twins Early Development Study who were assessed longitudinally for hyperactivity, conduct, emotional problems, and peer problems as rated by parents, teachers, and children themselves. GPS created from 15 genome‐wide association studies were used separately and jointly to test the prediction of behaviour problems composites (general behaviour problems, externalising, and internalising) across ages (from age 2 to 21) and across raters in penalised regression models. Based on the regression weights, we created multi‐trait GPS reflecting the best prediction of behaviour problems. We compared GPS prediction to twin heritability using the same sample and measures. Results: Multi‐GPS prediction of behaviour problems increased from <2% of the variance for observed traits to up to 6% for cross‐age and cross‐rater composites. Twin study estimates of heritability, although to a lesser extent, mirrored patterns of multi‐GPS prediction as they increased from <40% to 83%. Conclusions: The ability of GPS to predict behaviour problems can be improved by using multiple GPS, cross‐age composites and cross‐rater composites, although the effect sizes remain modest, up to 6%. Our approach can be used in any genotyped sample to create multi‐trait GPS predictors of behaviour problems that will be more predictive than polygenic scores based on a single age, rater, or GPS. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Child Psychology & Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/jcpp.13519 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 781 Subjects: – SubjectFull: DNA Type: general – SubjectFull: Transition to adulthood Type: general – SubjectFull: Descriptive statistics Type: general Titles: – TitleFull: Using DNA to predict behaviour problems from preschool to adulthood. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Gidziela, Agnieszka – PersonEntity: Name: NameFull: Rimfeld, Kaili – PersonEntity: Name: NameFull: Malanchini, Margherita – PersonEntity: Name: NameFull: Allegrini, Andrea G. – PersonEntity: Name: NameFull: McMillan, Andrew – PersonEntity: Name: NameFull: Selzam, Saskia – PersonEntity: Name: NameFull: Ronald, Angelica – PersonEntity: Name: NameFull: Viding, Essi – PersonEntity: Name: NameFull: von Stumm, Sophie – PersonEntity: Name: NameFull: Eley, Thalia C. – PersonEntity: Name: NameFull: Plomin, Robert IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 00219630 Numbering: – Type: volume Value: 63 – Type: issue Value: 7 Titles: – TitleFull: Journal of Child Psychology & Psychiatry Type: main |
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