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Premorbid Sociality Moderates Social Adjustment Change during Cognitive Enhancement Therapy for Adults with Early Schizophrenia.

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Title: Premorbid Sociality Moderates Social Adjustment Change during Cognitive Enhancement Therapy for Adults with Early Schizophrenia.
Authors: Wojtalik, Jessica A. (AUTHOR), Flores, Ana T. (AUTHOR), Keshavan, Matcheri S. (AUTHOR), Eack, Shaun M. (AUTHOR)
Source: Journal of Clinical Child & Adolescent Psychology. May/Jun2022, Vol. 51 Issue 3, p312-322. 11p.
Subjects: Social adjustment, Cognitive therapy, People with schizophrenia, Cognitive remediation, Social change
Abstract: Cognitive remediation approaches for early course schizophrenia are promising interventions for improving social adjustment. Premorbid sociality is a potentially important moderator of social adjustment response to cognitive remediation and may serve to personalize such interventions. Eighty-eight early course schizophrenia outpatients with premorbid sociality scores were included in this preliminary investigation. Secondary data came from a recent 18-month multi-site confirmatory trial of Cognitive Enhancement Therapy (CET) compared to Enriched Supportive Therapy (EST). Intent-to-treat mixed effects models examined the moderating effect of premorbid sociality assessed at baseline on differential social adjustment change between CET and EST assessed at baseline, 9, and 18 months. Premorbid sociality significantly moderated the differential effect of CET vs. EST on overall social adjustment change at 18 months, such that CET was particularly effective for patients with high premorbid sociality and EST for low premorbid sociality. This significant group x time x premorbid sociality interaction was also observed for 18-month change in interpersonal anguish, self-care, and sexual relations. Again, CET was largely favorable for higher premorbid sociality patients and EST for lower premorbid sociality for these sub-scales. The results provide initial evidence that premorbid sociality moderates differential social adjustment change during cognitive remediation in early course schizophrenia. In many, but not all cases, better social functioning prior to the development of schizophrenia was associated with a significantly better social adjustment response to CET. Data on social functioning during childhood and adolescence is possibly useful for personalizing treatment planning in the early course of schizophrenia. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Clinical Child & Adolescent Psychology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Premorbid Sociality Moderates Social Adjustment Change during Cognitive Enhancement Therapy for Adults with Early Schizophrenia.
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  Data: <searchLink fieldCode="AR" term="%22Wojtalik%2C+Jessica+A%2E%22">Wojtalik, Jessica A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Flores%2C+Ana+T%2E%22">Flores, Ana T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Keshavan%2C+Matcheri+S%2E%22">Keshavan, Matcheri S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Eack%2C+Shaun+M%2E%22">Eack, Shaun M.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Clinical+Child+%26+Adolescent+Psychology%22">Journal of Clinical Child & Adolescent Psychology</searchLink>. May/Jun2022, Vol. 51 Issue 3, p312-322. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Social+adjustment%22">Social adjustment</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+therapy%22">Cognitive therapy</searchLink><br /><searchLink fieldCode="DE" term="%22People+with+schizophrenia%22">People with schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+remediation%22">Cognitive remediation</searchLink><br /><searchLink fieldCode="DE" term="%22Social+change%22">Social change</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Cognitive remediation approaches for early course schizophrenia are promising interventions for improving social adjustment. Premorbid sociality is a potentially important moderator of social adjustment response to cognitive remediation and may serve to personalize such interventions. Eighty-eight early course schizophrenia outpatients with premorbid sociality scores were included in this preliminary investigation. Secondary data came from a recent 18-month multi-site confirmatory trial of Cognitive Enhancement Therapy (CET) compared to Enriched Supportive Therapy (EST). Intent-to-treat mixed effects models examined the moderating effect of premorbid sociality assessed at baseline on differential social adjustment change between CET and EST assessed at baseline, 9, and 18 months. Premorbid sociality significantly moderated the differential effect of CET vs. EST on overall social adjustment change at 18 months, such that CET was particularly effective for patients with high premorbid sociality and EST for low premorbid sociality. This significant group x time x premorbid sociality interaction was also observed for 18-month change in interpersonal anguish, self-care, and sexual relations. Again, CET was largely favorable for higher premorbid sociality patients and EST for lower premorbid sociality for these sub-scales. The results provide initial evidence that premorbid sociality moderates differential social adjustment change during cognitive remediation in early course schizophrenia. In many, but not all cases, better social functioning prior to the development of schizophrenia was associated with a significantly better social adjustment response to CET. Data on social functioning during childhood and adolescence is possibly useful for personalizing treatment planning in the early course of schizophrenia. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Clinical Child & Adolescent Psychology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1080/15374416.2022.2025599
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        Text: English
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        Type: general
      – SubjectFull: Cognitive therapy
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      – SubjectFull: People with schizophrenia
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            NameFull: Flores, Ana T.
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            NameFull: Keshavan, Matcheri S.
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              M: 05
              Text: May/Jun2022
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              Y: 2022
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