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Prodromal phase: Differences in prodromal symptoms, risk factors and markers of vulnerability in first episode mania versus first episode psychosis with onset in late adolescence or adulthood.

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Title: Prodromal phase: Differences in prodromal symptoms, risk factors and markers of vulnerability in first episode mania versus first episode psychosis with onset in late adolescence or adulthood.
Authors: Verdolini, Norma (AUTHOR), Borràs, Roger (AUTHOR), Sparacino, Giulio (AUTHOR), Garriga, Marina (AUTHOR), Sagué‐Vilavella, Maria (AUTHOR), Madero, Santiago (AUTHOR), Palacios‐Garrán, Roberto (AUTHOR), Serra, Maria (AUTHOR), Forte, Maria Florencia (AUTHOR), Salagre, Estela (AUTHOR), Aedo, Alberto (AUTHOR), Salgado‐Pineda, Pilar (AUTHOR), Salvatierra, Irene Montoro (AUTHOR), Sánchez Gistau, Vanessa (AUTHOR), Pomarol‐Clotet, Edith (AUTHOR), Ramos‐Quiroga, Josep Antoni (AUTHOR), Carvalho, Andre F. (AUTHOR), Garcia‐Rizo, Clemente (AUTHOR), Undurraga, Juan (AUTHOR), Reinares, María (AUTHOR)
Source: Acta Psychiatrica Scandinavica. Jul2022, Vol. 146 Issue 1, p36-50. 15p. 3 Charts, 1 Graph.
Subjects: Mania, Older people, Chi-squared test, Psychoses
Abstract: Objective: This study was aimed at identifying differences in the prodromal symptoms and their duration, risk factors and markers of vulnerability in patients presenting a first episode mania (FEM) or psychosis (FEP) with onset in late adolescence or adulthood in order to guide tailored treatment strategies. Methods: Patients with a FEM or FEP underwent a clinical assessment. Prodromes were evaluated with the Bipolar Prodrome Symptom Scale‐Retrospective (BPSS‐R). Chi‐squared tests were conducted to assess specific prodromal symptoms, risk factors or markers of vulnerability between groups. Significant prodromal symptoms were entered in a stepwise forward logistic regression model. The probabilities of a gradual versus rapid onset pattern of the prodromes were computed with logistic regression models. Results: The total sample included 108 patients (FEM = 72, FEP = 36). Social isolation was associated with the prodromal stage of a FEP whilst Increased energy or goal‐directed activity with the prodrome to a FEM. Physically slowed down presented the most gradual onset whilst Increased energy presented the most rapid. The presence of obstetric complications and difficulties in writing and reading during childhood were risk factors for FEP. As for markers of vulnerability, impairment in premorbid adjustment was characteristic of FEP patients. No specific risk factor or marker of vulnerability was identified for FEM. Conclusion: Early characteristics differentiating FEP from FEM were identified. These findings might help shape early identification and preventive intervention programmes. [ABSTRACT FROM AUTHOR]
Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Prodromal phase: Differences in prodromal symptoms, risk factors and markers of vulnerability in first episode mania versus first episode psychosis with onset in late adolescence or adulthood.
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  Data: <searchLink fieldCode="AR" term="%22Verdolini%2C+Norma%22">Verdolini, Norma</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Borràs%2C+Roger%22">Borràs, Roger</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sparacino%2C+Giulio%22">Sparacino, Giulio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Garriga%2C+Marina%22">Garriga, Marina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sagué‐Vilavella%2C+Maria%22">Sagué‐Vilavella, Maria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Madero%2C+Santiago%22">Madero, Santiago</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Palacios‐Garrán%2C+Roberto%22">Palacios‐Garrán, Roberto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Serra%2C+Maria%22">Serra, Maria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Forte%2C+Maria+Florencia%22">Forte, Maria Florencia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Salagre%2C+Estela%22">Salagre, Estela</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Aedo%2C+Alberto%22">Aedo, Alberto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Salgado‐Pineda%2C+Pilar%22">Salgado‐Pineda, Pilar</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Salvatierra%2C+Irene+Montoro%22">Salvatierra, Irene Montoro</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sánchez+Gistau%2C+Vanessa%22">Sánchez Gistau, Vanessa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pomarol‐Clotet%2C+Edith%22">Pomarol‐Clotet, Edith</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ramos‐Quiroga%2C+Josep+Antoni%22">Ramos‐Quiroga, Josep Antoni</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Carvalho%2C+Andre+F%2E%22">Carvalho, Andre F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Garcia‐Rizo%2C+Clemente%22">Garcia‐Rizo, Clemente</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Undurraga%2C+Juan%22">Undurraga, Juan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Reinares%2C+María%22">Reinares, María</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Psychiatrica+Scandinavica%22">Acta Psychiatrica Scandinavica</searchLink>. Jul2022, Vol. 146 Issue 1, p36-50. 15p. 3 Charts, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Mania%22">Mania</searchLink><br /><searchLink fieldCode="DE" term="%22Older+people%22">Older people</searchLink><br /><searchLink fieldCode="DE" term="%22Chi-squared+test%22">Chi-squared test</searchLink><br /><searchLink fieldCode="DE" term="%22Psychoses%22">Psychoses</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Objective: This study was aimed at identifying differences in the prodromal symptoms and their duration, risk factors and markers of vulnerability in patients presenting a first episode mania (FEM) or psychosis (FEP) with onset in late adolescence or adulthood in order to guide tailored treatment strategies. Methods: Patients with a FEM or FEP underwent a clinical assessment. Prodromes were evaluated with the Bipolar Prodrome Symptom Scale‐Retrospective (BPSS‐R). Chi‐squared tests were conducted to assess specific prodromal symptoms, risk factors or markers of vulnerability between groups. Significant prodromal symptoms were entered in a stepwise forward logistic regression model. The probabilities of a gradual versus rapid onset pattern of the prodromes were computed with logistic regression models. Results: The total sample included 108 patients (FEM = 72, FEP = 36). Social isolation was associated with the prodromal stage of a FEP whilst Increased energy or goal‐directed activity with the prodrome to a FEM. Physically slowed down presented the most gradual onset whilst Increased energy presented the most rapid. The presence of obstetric complications and difficulties in writing and reading during childhood were risk factors for FEP. As for markers of vulnerability, impairment in premorbid adjustment was characteristic of FEP patients. No specific risk factor or marker of vulnerability was identified for FEM. Conclusion: Early characteristics differentiating FEP from FEM were identified. These findings might help shape early identification and preventive intervention programmes. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/acps.13415
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        Text: English
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