Shared and distinct reward neural mechanisms among patients with schizophrenia, major depressive disorder, and bipolar disorder: an effort-based functional imaging study.
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| Title: | Shared and distinct reward neural mechanisms among patients with schizophrenia, major depressive disorder, and bipolar disorder: an effort-based functional imaging study. |
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| Authors: | Wang, Yan-yu (AUTHOR), Wang, Yi (AUTHOR), Huang, Jia (AUTHOR), Sun, Xi-he (AUTHOR), Wang, Xi-zhen (AUTHOR), Zhang, Shu-xian (AUTHOR), Zhu, Guo-hui (AUTHOR), Lui, Simon S. Y. (AUTHOR), Cheung, Eric F. C. (AUTHOR), Sun, Hong-wei (AUTHOR), Chan, Raymond C. K. (AUTHOR) |
| Source: | European Archives of Psychiatry & Clinical Neuroscience. Aug2022, Vol. 272 Issue 5, p859-871. 13p. 3 Charts, 2 Graphs. |
| Subjects: | Reward (Psychology), Mental depression, Bipolar disorder, Temporal lobe, Prefrontal cortex |
| Abstract: | Unwillingness to exert effort for rewards has been found in patients with schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BD), but the underlying shared and distinct reward neural mechanisms remain unclear. This study aimed to compare the neural correlates of such impairments across different diagnoses. The neural responses in an effort-expenditure for reward task (EEfRT) were assessed in 20 SCZ patients, 23 MDD patients, 17 BD patients, and 30 healthy controls (HC). The results found shared activation in the cingulate gyrus, the medial frontal gyrus, and the middle frontal gyrus during the EEfRT administration. Compared to HC, SCZ patients exhibited stronger variations of functional connectivity between the right caudate and the left amygdala, the left hippocampus and the left putamen, with increase in reward magnitude. In MDD patients, an enhanced activation compared to HC in the right superior temporal gyrus was found with the increase of reward magnitude. The variations of functional connectivity between the caudate and the right cingulate gyrus, the left postcentral gyrus and the left inferior parietal lobule with increase in reward magnitude were weaker than that found in HC. In BD patients, the degree of activation in the left precuneus was increased, but that in the left dorsolateral prefrontal cortex was decreased with increase in reward probability compared to HC. These findings demonstrate both shared and distinct reward neural mechanisms associated with EEfRT in patients with SCZ, MDD, and BD, implicating potential intervention targets to alleviate amotivation in these clinical disorders. [ABSTRACT FROM AUTHOR] |
| Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 157956279 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Shared and distinct reward neural mechanisms among patients with schizophrenia, major depressive disorder, and bipolar disorder: an effort-based functional imaging study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Wang%2C+Yan-yu%22">Wang, Yan-yu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Yi%22">Wang, Yi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huang%2C+Jia%22">Huang, Jia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sun%2C+Xi-he%22">Sun, Xi-he</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Xi-zhen%22">Wang, Xi-zhen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Shu-xian%22">Zhang, Shu-xian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhu%2C+Guo-hui%22">Zhu, Guo-hui</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lui%2C+Simon+S%2E+Y%2E%22">Lui, Simon S. Y.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cheung%2C+Eric+F%2E+C%2E%22">Cheung, Eric F. C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sun%2C+Hong-wei%22">Sun, Hong-wei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chan%2C+Raymond+C%2E+K%2E%22">Chan, Raymond C. K.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Aug2022, Vol. 272 Issue 5, p859-871. 13p. 3 Charts, 2 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Reward+%28Psychology%29%22">Reward (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Temporal+lobe%22">Temporal lobe</searchLink><br /><searchLink fieldCode="DE" term="%22Prefrontal+cortex%22">Prefrontal cortex</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Unwillingness to exert effort for rewards has been found in patients with schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BD), but the underlying shared and distinct reward neural mechanisms remain unclear. This study aimed to compare the neural correlates of such impairments across different diagnoses. The neural responses in an effort-expenditure for reward task (EEfRT) were assessed in 20 SCZ patients, 23 MDD patients, 17 BD patients, and 30 healthy controls (HC). The results found shared activation in the cingulate gyrus, the medial frontal gyrus, and the middle frontal gyrus during the EEfRT administration. Compared to HC, SCZ patients exhibited stronger variations of functional connectivity between the right caudate and the left amygdala, the left hippocampus and the left putamen, with increase in reward magnitude. In MDD patients, an enhanced activation compared to HC in the right superior temporal gyrus was found with the increase of reward magnitude. The variations of functional connectivity between the caudate and the right cingulate gyrus, the left postcentral gyrus and the left inferior parietal lobule with increase in reward magnitude were weaker than that found in HC. In BD patients, the degree of activation in the left precuneus was increased, but that in the left dorsolateral prefrontal cortex was decreased with increase in reward probability compared to HC. These findings demonstrate both shared and distinct reward neural mechanisms associated with EEfRT in patients with SCZ, MDD, and BD, implicating potential intervention targets to alleviate amotivation in these clinical disorders. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=157956279 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00406-021-01376-3 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 859 Subjects: – SubjectFull: Reward (Psychology) Type: general – SubjectFull: Mental depression Type: general – SubjectFull: Bipolar disorder Type: general – SubjectFull: Temporal lobe Type: general – SubjectFull: Prefrontal cortex Type: general Titles: – TitleFull: Shared and distinct reward neural mechanisms among patients with schizophrenia, major depressive disorder, and bipolar disorder: an effort-based functional imaging study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Wang, Yan-yu – PersonEntity: Name: NameFull: Wang, Yi – PersonEntity: Name: NameFull: Huang, Jia – PersonEntity: Name: NameFull: Sun, Xi-he – PersonEntity: Name: NameFull: Wang, Xi-zhen – PersonEntity: Name: NameFull: Zhang, Shu-xian – PersonEntity: Name: NameFull: Zhu, Guo-hui – PersonEntity: Name: NameFull: Lui, Simon S. Y. – PersonEntity: Name: NameFull: Cheung, Eric F. C. – PersonEntity: Name: NameFull: Sun, Hong-wei – PersonEntity: Name: NameFull: Chan, Raymond C. K. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 09401334 Numbering: – Type: volume Value: 272 – Type: issue Value: 5 Titles: – TitleFull: European Archives of Psychiatry & Clinical Neuroscience Type: main |
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