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Allergic and non-allergic asthma phenotypes and exposure to air pollution.

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Title: Allergic and non-allergic asthma phenotypes and exposure to air pollution.
Authors: Pekince, md, Busra (AUTHOR), Baccioglu, md, Ayse (AUTHOR)
Source: Journal of Asthma. Aug2022, Vol. 59 Issue 8, p1509-1520. 12p.
Subjects: Air pollution, Cough, Oxidant status, Asthma, Respiratory organs, Pulmonary function tests
Abstract: Although harmful effects of air pollution on airway diseases are well-established, its effect on allergy still remains unclear. The aim of this study was to examine changes on asthma clinic and oxidant homeostasis due to air pollution between allergic asthma (AA) and non-allergic asthma (NA) phenotypes. This prospective, case-control study included patients with well-controlled asthma under regular treatment (n = 57) and healthy individuals (n = 51). Of asthma patients, 22 had AA and 35 had NA phenotypes. Respiratory symptoms, pulmonary function tests, serum total antioxidant status (TAS) and total oxidant status (TOS), and thiol/disulfide levels were compared between the most (V1) and least (V2) air-polluted times. High air pollution exposure resulted to an increase in the frequency of respiratory symptoms and serum inflammation markers in both asthmatic and healthy individuals. Frequency of dyspnea and cough in AA and rhinitis in NA decreased from V1 to V2. Hospitalization due to asthma exacerbation, systemic corticosteroid use, and eosinophil counts were more frequent in NA group than AA in V1. An increase of blood eosinophil counts was observed in AA group at the same visit. Mean TAS and TOS levels were higher in asthma group than control group, and the decline in TAS and TOS levels from V1 to V2 was seen only in NA. All thiols decreased and SH/total SH ratios significantly increased from V1 to V2 in all groups. This study demonstrates that air pollution affects both asthma patients and healthy individuals. Through oxidant-antioxidant and thiol pathways, however, it adversely affects respiratory system of asthma patients, at a greater extent, than healthy individuals. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Asthma is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Allergic and non-allergic asthma phenotypes and exposure to air pollution.
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  Data: <searchLink fieldCode="AR" term="%22Pekince%2C+md%2C+Busra%22">Pekince, md, Busra</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Baccioglu%2C+md%2C+Ayse%22">Baccioglu, md, Ayse</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Asthma%22">Journal of Asthma</searchLink>. Aug2022, Vol. 59 Issue 8, p1509-1520. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Air+pollution%22">Air pollution</searchLink><br /><searchLink fieldCode="DE" term="%22Cough%22">Cough</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidant+status%22">Oxidant status</searchLink><br /><searchLink fieldCode="DE" term="%22Asthma%22">Asthma</searchLink><br /><searchLink fieldCode="DE" term="%22Respiratory+organs%22">Respiratory organs</searchLink><br /><searchLink fieldCode="DE" term="%22Pulmonary+function+tests%22">Pulmonary function tests</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Although harmful effects of air pollution on airway diseases are well-established, its effect on allergy still remains unclear. The aim of this study was to examine changes on asthma clinic and oxidant homeostasis due to air pollution between allergic asthma (AA) and non-allergic asthma (NA) phenotypes. This prospective, case-control study included patients with well-controlled asthma under regular treatment (n = 57) and healthy individuals (n = 51). Of asthma patients, 22 had AA and 35 had NA phenotypes. Respiratory symptoms, pulmonary function tests, serum total antioxidant status (TAS) and total oxidant status (TOS), and thiol/disulfide levels were compared between the most (V1) and least (V2) air-polluted times. High air pollution exposure resulted to an increase in the frequency of respiratory symptoms and serum inflammation markers in both asthmatic and healthy individuals. Frequency of dyspnea and cough in AA and rhinitis in NA decreased from V1 to V2. Hospitalization due to asthma exacerbation, systemic corticosteroid use, and eosinophil counts were more frequent in NA group than AA in V1. An increase of blood eosinophil counts was observed in AA group at the same visit. Mean TAS and TOS levels were higher in asthma group than control group, and the decline in TAS and TOS levels from V1 to V2 was seen only in NA. All thiols decreased and SH/total SH ratios significantly increased from V1 to V2 in all groups. This study demonstrates that air pollution affects both asthma patients and healthy individuals. Through oxidant-antioxidant and thiol pathways, however, it adversely affects respiratory system of asthma patients, at a greater extent, than healthy individuals. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Asthma is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=157957294
RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1080/02770903.2021.1955133
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      – Code: eng
        Text: English
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        PageCount: 12
        StartPage: 1509
    Subjects:
      – SubjectFull: Air pollution
        Type: general
      – SubjectFull: Cough
        Type: general
      – SubjectFull: Oxidant status
        Type: general
      – SubjectFull: Asthma
        Type: general
      – SubjectFull: Respiratory organs
        Type: general
      – SubjectFull: Pulmonary function tests
        Type: general
    Titles:
      – TitleFull: Allergic and non-allergic asthma phenotypes and exposure to air pollution.
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            NameFull: Pekince, md, Busra
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            NameFull: Baccioglu, md, Ayse
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          Dates:
            – D: 01
              M: 08
              Text: Aug2022
              Type: published
              Y: 2022
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              Value: 59
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              Value: 8
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