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Ambient air pollution and epileptic seizures: A panel study in Australia.

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Title: Ambient air pollution and epileptic seizures: A panel study in Australia.
Authors: Chen, Zhuying (AUTHOR), Yu, Wenhua (AUTHOR), Xu, Rongbin (AUTHOR), Karoly, Philippa J. (AUTHOR), Maturana, Matias I. (AUTHOR), Payne, Daniel E. (AUTHOR), Li, Lyra (AUTHOR), Nurse, Ewan S. (AUTHOR), Freestone, Dean R. (AUTHOR), Li, Shanshan (AUTHOR), Burkitt, Anthony N. (AUTHOR), Cook, Mark J. (AUTHOR), Guo, Yuming (AUTHOR), Grayden, David B. (AUTHOR)
Source: Epilepsia (Series 4). Jul2022, Vol. 63 Issue 7, p1682-1692. 11p.
Subjects: Epilepsy, Air pollution, Panel analysis, Partial epilepsy, Air pollutants
Geographic Terms: Australia
Abstract: Objective: Emerging evidence has shown that ambient air pollution affects brain health, but little is known about its effect on epileptic seizures. This work aimed to assess the association between daily exposure to ambient air pollution and the risk of epileptic seizures. Methods: This study used epileptic seizure data from two independent data sources (NeuroVista and Seer App seizure diary). In the NeuroVista data set, 3273 seizures were recorded using intracranial electroencephalography (iEEG) from 15 participants with refractory focal epilepsy in Australia in 2010–2012. In the seizure diary data set, 3419 self‐reported seizures were collected through a mobile application from 34 participants with epilepsy in Australia in 2018–2021. Daily average concentrations of carbon monoxide (CO), nitrogen dioxide (NO2), ozone (O3), particulate matter ≤10 μm in diameter (PM10), and sulfur dioxide (SO2) were retrieved from the Environment Protection Authority (EPA) based on participants' postcodes. A patient‐time‐stratified case‐crossover design with the conditional Poisson regression model was used to determine the associations between air pollutants and epileptic seizures. Results: A significant association between CO concentrations and epileptic seizure risks was observed, with an increased seizure risk of 4% (relative risk [RR]: 1.04, 95% confidence interval [CI]: 1.01–1.07) for an interquartile range (IQR) increase of CO concentrations (0.13 parts per million), whereas no significant associations were found for the other four air pollutants in the whole study population. Female participants had a significantly increased risk of seizures when exposed to elevated CO and NO2, with RRs of 1.05 (95% CI: 1.01–1.08) and 1.09 (95% CI: 1.01–1.16), respectively. In addition, a significant association was observed between CO and the risk of subclinical seizures (RR: 1.20, 95% CI: 1.12–1.28). Significance: Daily exposure to elevated CO concentrations may be associated with an increased risk of epileptic seizures, especially for subclinical seizures. [ABSTRACT FROM AUTHOR]
Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Ambient air pollution and epileptic seizures: A panel study in Australia.
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  Data: <searchLink fieldCode="AR" term="%22Chen%2C+Zhuying%22">Chen, Zhuying</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yu%2C+Wenhua%22">Yu, Wenhua</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Rongbin%22">Xu, Rongbin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Karoly%2C+Philippa+J%2E%22">Karoly, Philippa J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Maturana%2C+Matias+I%2E%22">Maturana, Matias I.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Payne%2C+Daniel+E%2E%22">Payne, Daniel E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Lyra%22">Li, Lyra</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nurse%2C+Ewan+S%2E%22">Nurse, Ewan S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Freestone%2C+Dean+R%2E%22">Freestone, Dean R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Shanshan%22">Li, Shanshan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Burkitt%2C+Anthony+N%2E%22">Burkitt, Anthony N.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cook%2C+Mark+J%2E%22">Cook, Mark J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guo%2C+Yuming%22">Guo, Yuming</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Grayden%2C+David+B%2E%22">Grayden, David B.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Epilepsia+%28Series+4%29%22">Epilepsia (Series 4)</searchLink>. Jul2022, Vol. 63 Issue 7, p1682-1692. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Epilepsy%22">Epilepsy</searchLink><br /><searchLink fieldCode="DE" term="%22Air+pollution%22">Air pollution</searchLink><br /><searchLink fieldCode="DE" term="%22Panel+analysis%22">Panel analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Partial+epilepsy%22">Partial epilepsy</searchLink><br /><searchLink fieldCode="DE" term="%22Air+pollutants%22">Air pollutants</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Australia%22">Australia</searchLink>
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  Data: Objective: Emerging evidence has shown that ambient air pollution affects brain health, but little is known about its effect on epileptic seizures. This work aimed to assess the association between daily exposure to ambient air pollution and the risk of epileptic seizures. Methods: This study used epileptic seizure data from two independent data sources (NeuroVista and Seer App seizure diary). In the NeuroVista data set, 3273 seizures were recorded using intracranial electroencephalography (iEEG) from 15 participants with refractory focal epilepsy in Australia in 2010–2012. In the seizure diary data set, 3419 self‐reported seizures were collected through a mobile application from 34 participants with epilepsy in Australia in 2018–2021. Daily average concentrations of carbon monoxide (CO), nitrogen dioxide (NO2), ozone (O3), particulate matter ≤10 μm in diameter (PM10), and sulfur dioxide (SO2) were retrieved from the Environment Protection Authority (EPA) based on participants' postcodes. A patient‐time‐stratified case‐crossover design with the conditional Poisson regression model was used to determine the associations between air pollutants and epileptic seizures. Results: A significant association between CO concentrations and epileptic seizure risks was observed, with an increased seizure risk of 4% (relative risk [RR]: 1.04, 95% confidence interval [CI]: 1.01–1.07) for an interquartile range (IQR) increase of CO concentrations (0.13 parts per million), whereas no significant associations were found for the other four air pollutants in the whole study population. Female participants had a significantly increased risk of seizures when exposed to elevated CO and NO2, with RRs of 1.05 (95% CI: 1.01–1.08) and 1.09 (95% CI: 1.01–1.16), respectively. In addition, a significant association was observed between CO and the risk of subclinical seizures (RR: 1.20, 95% CI: 1.12–1.28). Significance: Daily exposure to elevated CO concentrations may be associated with an increased risk of epileptic seizures, especially for subclinical seizures. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1111/epi.17253
    Languages:
      – Code: eng
        Text: English
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        PageCount: 11
        StartPage: 1682
    Subjects:
      – SubjectFull: Epilepsy
        Type: general
      – SubjectFull: Air pollution
        Type: general
      – SubjectFull: Panel analysis
        Type: general
      – SubjectFull: Partial epilepsy
        Type: general
      – SubjectFull: Air pollutants
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      – SubjectFull: Australia
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      – TitleFull: Ambient air pollution and epileptic seizures: A panel study in Australia.
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              M: 07
              Text: Jul2022
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              Y: 2022
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