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Subjects with bipolar disorder showed different reward system activation than subjects with major depressive disorder in the monetary incentive delay task.

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Title: Subjects with bipolar disorder showed different reward system activation than subjects with major depressive disorder in the monetary incentive delay task.
Authors: Wakatsuki, Yumi (AUTHOR), Ogura, Yukiko (AUTHOR), Hashimoto, Naoki (AUTHOR), Toyomaki, Atsuhito (AUTHOR), Miyamoto, Tamaki (AUTHOR), Nakagawa, Shin (AUTHOR), Inoue, Takeshi (AUTHOR), Kusumi, Ichiro (AUTHOR)
Source: Psychiatry & Clinical Neurosciences. Aug2022, Vol. 76 Issue 8, p393-400. 8p. 4 Charts, 1 Graph.
Subjects: Reward (Psychology), Mental depression, Monetary incentives, Bipolar disorder, Hypomania, Delay of gratification, Functional magnetic resonance imaging
Abstract: Background: Differentiating between bipolar disorder (BD) and major depressive disorder (MDD) during the depressive episode is an important clinical challenge. Reward system abnormalities have received much attention as one of the biological underpinnings of BD and MDD, but few studies have directly compared these abnormalities in remitted and depressed states. Methods: This was a functional MRI study using the Monetary Incentive Delay task in 65 patients (BD [n = 33], MDD [n = 32]) and 33 healthy controls (HC). Regions of interest (ROI) analysis with 21 ROIs related to reward anticipation and 17 ROIs related to gain outcome were implemented, as well as whole‐brain analysis. The difference in the dimensional effect of depression on brain activation was also examined. Results: Relative to the HC group, BD patients showed significantly decreased activation during reward anticipation in the anterior cingulate cortex, anterior insula (AI), and putamen, and MDD patients showed significantly decreased activation in the AI and brainstem. The dimensional effect of depression severity showed a trend‐level difference between BD and MDD in the right brainstem and left AI. Conclusions: The current study showed a possible differential effect of depression on the reward system between MDD and BD. Further studies on reward systems might offer reliable markers to distinguish between MDD and BD patients in the depressive phase. [ABSTRACT FROM AUTHOR]
Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
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  Data: Subjects with bipolar disorder showed different reward system activation than subjects with major depressive disorder in the monetary incentive delay task.
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  Data: <searchLink fieldCode="AR" term="%22Wakatsuki%2C+Yumi%22">Wakatsuki, Yumi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ogura%2C+Yukiko%22">Ogura, Yukiko</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hashimoto%2C+Naoki%22">Hashimoto, Naoki</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Toyomaki%2C+Atsuhito%22">Toyomaki, Atsuhito</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Miyamoto%2C+Tamaki%22">Miyamoto, Tamaki</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nakagawa%2C+Shin%22">Nakagawa, Shin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Inoue%2C+Takeshi%22">Inoue, Takeshi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kusumi%2C+Ichiro%22">Kusumi, Ichiro</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Psychiatry+%26+Clinical+Neurosciences%22">Psychiatry & Clinical Neurosciences</searchLink>. Aug2022, Vol. 76 Issue 8, p393-400. 8p. 4 Charts, 1 Graph.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Reward+%28Psychology%29%22">Reward (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Monetary+incentives%22">Monetary incentives</searchLink><br /><searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Hypomania%22">Hypomania</searchLink><br /><searchLink fieldCode="DE" term="%22Delay+of+gratification%22">Delay of gratification</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+magnetic+resonance+imaging%22">Functional magnetic resonance imaging</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Differentiating between bipolar disorder (BD) and major depressive disorder (MDD) during the depressive episode is an important clinical challenge. Reward system abnormalities have received much attention as one of the biological underpinnings of BD and MDD, but few studies have directly compared these abnormalities in remitted and depressed states. Methods: This was a functional MRI study using the Monetary Incentive Delay task in 65 patients (BD [n = 33], MDD [n = 32]) and 33 healthy controls (HC). Regions of interest (ROI) analysis with 21 ROIs related to reward anticipation and 17 ROIs related to gain outcome were implemented, as well as whole‐brain analysis. The difference in the dimensional effect of depression on brain activation was also examined. Results: Relative to the HC group, BD patients showed significantly decreased activation during reward anticipation in the anterior cingulate cortex, anterior insula (AI), and putamen, and MDD patients showed significantly decreased activation in the AI and brainstem. The dimensional effect of depression severity showed a trend‐level difference between BD and MDD in the right brainstem and left AI. Conclusions: The current study showed a possible differential effect of depression on the reward system between MDD and BD. Further studies on reward systems might offer reliable markers to distinguish between MDD and BD patients in the depressive phase. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/pcn.13429
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      – SubjectFull: Monetary incentives
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      – SubjectFull: Delay of gratification
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      – SubjectFull: Functional magnetic resonance imaging
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              Text: Aug2022
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