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The Italian tremor Network (TITAN): rationale, design and preliminary findings.

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Title: The Italian tremor Network (TITAN): rationale, design and preliminary findings.
Authors: Erro, Roberto (AUTHOR), Pilotto, Andrea (AUTHOR), Esposito, Marcello (AUTHOR), Olivola, Enrica (AUTHOR), Nicoletti, Alessandra (AUTHOR), Lazzeri, Giulia (AUTHOR), Magistrelli, Luca (AUTHOR), Dallocchio, Carlo (AUTHOR), Marchese, Roberta (AUTHOR), Bologna, Matteo (AUTHOR), Tessitore, Alessandro (AUTHOR), Misceo, Salvatore (AUTHOR), Gigante, Angelo Fabio (AUTHOR), Terranova, Carmen (AUTHOR), Moschella, Vincenzo (AUTHOR), di Biase, Lazzaro (AUTHOR), Di Giacopo, Raffaella (AUTHOR), Morgante, Francesca (AUTHOR), Valentino, Francesca (AUTHOR), De Rosa, Anna (AUTHOR)
Source: Neurological Sciences. Sep2022, Vol. 43 Issue 9, p5369-5376. 8p. 3 Charts.
Abstract: Introduction: The recently released classification has revised the nosology of tremor, defining essential tremor (ET) as a syndrome and fueling an enlightened debate about some newly conceptualized entities such as ET-plus. As a result, precise information of demographics, clinical features, and about the natural history of these conditions are lacking. Methods: The ITAlian tremor Network (TITAN) is a multicenter data collection platform, the aim of which is to prospectively assess, according to a standardized protocol, the phenomenology and natural history of tremor syndromes. Results: In the first year of activity, 679 patients have been recruited. The frequency of tremor syndromes varied from 32% of ET and 41% of ET-plus to less than 3% of rare forms, including focal tremors (2.30%), task-specific tremors (1.38%), isolated rest tremor (0.61%), and orthostatic tremor (0.61%). Patients with ET-plus were older and had a higher age at onset than ET, but a shorter disease duration, which might suggest that ET-plus is not a disease stage of ET. Familial aggregation of tremor and movement disorders was present in up to 60% of ET cases and in about 40% of patients with tremor combined with dystonia. The body site of tremor onset was different between tremor syndromes, with head tremor being most commonly, but not uniquely, associated with dystonia. Conclusions: The TITAN study is anticipated to provide clinically relevant prospective information about the clinical correlates of different tremor syndromes and their specific outcomes and might serve as a basis for future etiological, pathophysiological, and therapeutic research. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: The Italian tremor Network (TITAN): rationale, design and preliminary findings.
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  Data: <searchLink fieldCode="AR" term="%22Erro%2C+Roberto%22">Erro, Roberto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pilotto%2C+Andrea%22">Pilotto, Andrea</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Esposito%2C+Marcello%22">Esposito, Marcello</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Olivola%2C+Enrica%22">Olivola, Enrica</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nicoletti%2C+Alessandra%22">Nicoletti, Alessandra</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lazzeri%2C+Giulia%22">Lazzeri, Giulia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Magistrelli%2C+Luca%22">Magistrelli, Luca</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dallocchio%2C+Carlo%22">Dallocchio, Carlo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Marchese%2C+Roberta%22">Marchese, Roberta</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bologna%2C+Matteo%22">Bologna, Matteo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tessitore%2C+Alessandro%22">Tessitore, Alessandro</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Misceo%2C+Salvatore%22">Misceo, Salvatore</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gigante%2C+Angelo+Fabio%22">Gigante, Angelo Fabio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Terranova%2C+Carmen%22">Terranova, Carmen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Moschella%2C+Vincenzo%22">Moschella, Vincenzo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22di+Biase%2C+Lazzaro%22">di Biase, Lazzaro</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Di+Giacopo%2C+Raffaella%22">Di Giacopo, Raffaella</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Morgante%2C+Francesca%22">Morgante, Francesca</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Valentino%2C+Francesca%22">Valentino, Francesca</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22De+Rosa%2C+Anna%22">De Rosa, Anna</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Sep2022, Vol. 43 Issue 9, p5369-5376. 8p. 3 Charts.
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  Data: Introduction: The recently released classification has revised the nosology of tremor, defining essential tremor (ET) as a syndrome and fueling an enlightened debate about some newly conceptualized entities such as ET-plus. As a result, precise information of demographics, clinical features, and about the natural history of these conditions are lacking. Methods: The ITAlian tremor Network (TITAN) is a multicenter data collection platform, the aim of which is to prospectively assess, according to a standardized protocol, the phenomenology and natural history of tremor syndromes. Results: In the first year of activity, 679 patients have been recruited. The frequency of tremor syndromes varied from 32% of ET and 41% of ET-plus to less than 3% of rare forms, including focal tremors (2.30%), task-specific tremors (1.38%), isolated rest tremor (0.61%), and orthostatic tremor (0.61%). Patients with ET-plus were older and had a higher age at onset than ET, but a shorter disease duration, which might suggest that ET-plus is not a disease stage of ET. Familial aggregation of tremor and movement disorders was present in up to 60% of ET cases and in about 40% of patients with tremor combined with dystonia. The body site of tremor onset was different between tremor syndromes, with head tremor being most commonly, but not uniquely, associated with dystonia. Conclusions: The TITAN study is anticipated to provide clinically relevant prospective information about the clinical correlates of different tremor syndromes and their specific outcomes and might serve as a basis for future etiological, pathophysiological, and therapeutic research. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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