The associations of CD4 count, CD4/CD8 ratio, and HIV viral load with survival from non-small cell lung cancer in persons living with HIV.
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| Title: | The associations of CD4 count, CD4/CD8 ratio, and HIV viral load with survival from non-small cell lung cancer in persons living with HIV. |
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| Authors: | Klugman, M., Fazzari, M., Xue, X., Ginsberg, M., Rohan, T. E., Halmos, B., Hanna, D. B., Shuter, J., Hosgood III, H. D. |
| Source: | AIDS Care. Aug2022, Vol. 34 Issue 8, p1014-1021. 8p. 4 Charts, 1 Graph. |
| Subjects: | Lung cancer complications, HIV infection prognosis, Lung cancer diagnosis, HIV-positive persons, HIV infections, Biomarkers, Confidence intervals, Viral load, Cancer patients, CD4 lymphocyte count |
| Abstract: | HIV status may influence survival from non-small cell lung cancer (NSCLC). Among NSCLC patients in the Bronx, NY, we assessed (1) associations of CD4 count, CD4/CD8 ratio and HIV viral load (VL) with survival and (2) prognostic factors among persons living with HIV (PLWH). We compared survival from NSCLC diagnosis (2004–2017) between HIV-negative persons (HIV-, n=2,881) and PLWH (n=88) accounting for clinical and sociodemographic factors. HIV-survival was also compared with PLWH, dichotomized by CD4 (<200 vs. ≥200cells/µL), CD4/CD8 (median, <0.43 vs. ≥0.43) and VL (<75 vs. ≥75copies/mL) at NSCLC diagnosis. Among PLWH, we assessed the relationships of CD4, CD4/CD8, and VL with survival, adjusting for age, sex, and cancer stage. PLWH with CD4< 200cells/µL had lower survival than HIV- [hazard ratio, 95% confidence interval [HR(95%CI)]=1.86(0.98–3.55)]. Survival was similar between PLWH with CD4≥ 200cells/µL and HIV- [HR(95%CI) = 0.90(0.61–1.33)]. Results were similar when categorizing PLWH by CD4/CD8 [vs. HIV-: low CD4/CD8: HR(95%CI) = 1.74(1.07–3.89); high CD4/CD8: HR(95%CI) = 0.63(0.37–1.07)] and VL [vs. HIV-: <75copies/mL: HR(95%CI) = 0.74(0.46–1.21), ≥75copies/mL: HR(95%CI) = 1.41(0.88–2.27)]. Among PLWH, CD4< 200cells/µL was associated with worse survival [vs. CD4≥ 200cells/µL: HR(95%CI) = 2.37(1.14–4.92)]. CD4, CD4/CD8, and VL may be prognostic markers for PLWH with NSCLC, suggesting immune status may be important in NSCLC survival among PLWH. [ABSTRACT FROM AUTHOR] |
| Copyright of AIDS Care is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 158669741 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The associations of CD4 count, CD4/CD8 ratio, and HIV viral load with survival from non-small cell lung cancer in persons living with HIV. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Klugman%2C+M%2E%22">Klugman, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Fazzari%2C+M%2E%22">Fazzari, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Xue%2C+X%2E%22">Xue, X.</searchLink><br /><searchLink fieldCode="AR" term="%22Ginsberg%2C+M%2E%22">Ginsberg, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Rohan%2C+T%2E+E%2E%22">Rohan, T. E.</searchLink><br /><searchLink fieldCode="AR" term="%22Halmos%2C+B%2E%22">Halmos, B.</searchLink><br /><searchLink fieldCode="AR" term="%22Hanna%2C+D%2E+B%2E%22">Hanna, D. B.</searchLink><br /><searchLink fieldCode="AR" term="%22Shuter%2C+J%2E%22">Shuter, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Hosgood+III%2C+H%2E+D%2E%22">Hosgood III, H. D.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22AIDS+Care%22">AIDS Care</searchLink>. Aug2022, Vol. 34 Issue 8, p1014-1021. 8p. 4 Charts, 1 Graph. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Lung+cancer+complications%22">Lung cancer complications</searchLink><br /><searchLink fieldCode="DE" term="%22HIV+infection+prognosis%22">HIV infection prognosis</searchLink><br /><searchLink fieldCode="DE" term="%22Lung+cancer+diagnosis%22">Lung cancer diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22HIV-positive+persons%22">HIV-positive persons</searchLink><br /><searchLink fieldCode="DE" term="%22HIV+infections%22">HIV infections</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Viral+load%22">Viral load</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+patients%22">Cancer patients</searchLink><br /><searchLink fieldCode="DE" term="%22CD4+lymphocyte+count%22">CD4 lymphocyte count</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: HIV status may influence survival from non-small cell lung cancer (NSCLC). Among NSCLC patients in the Bronx, NY, we assessed (1) associations of CD4 count, CD4/CD8 ratio and HIV viral load (VL) with survival and (2) prognostic factors among persons living with HIV (PLWH). We compared survival from NSCLC diagnosis (2004–2017) between HIV-negative persons (HIV-, n=2,881) and PLWH (n=88) accounting for clinical and sociodemographic factors. HIV-survival was also compared with PLWH, dichotomized by CD4 (<200 vs. ≥200cells/µL), CD4/CD8 (median, <0.43 vs. ≥0.43) and VL (<75 vs. ≥75copies/mL) at NSCLC diagnosis. Among PLWH, we assessed the relationships of CD4, CD4/CD8, and VL with survival, adjusting for age, sex, and cancer stage. PLWH with CD4< 200cells/µL had lower survival than HIV- [hazard ratio, 95% confidence interval [HR(95%CI)]=1.86(0.98–3.55)]. Survival was similar between PLWH with CD4≥ 200cells/µL and HIV- [HR(95%CI) = 0.90(0.61–1.33)]. Results were similar when categorizing PLWH by CD4/CD8 [vs. HIV-: low CD4/CD8: HR(95%CI) = 1.74(1.07–3.89); high CD4/CD8: HR(95%CI) = 0.63(0.37–1.07)] and VL [vs. HIV-: <75copies/mL: HR(95%CI) = 0.74(0.46–1.21), ≥75copies/mL: HR(95%CI) = 1.41(0.88–2.27)]. Among PLWH, CD4< 200cells/µL was associated with worse survival [vs. CD4≥ 200cells/µL: HR(95%CI) = 2.37(1.14–4.92)]. CD4, CD4/CD8, and VL may be prognostic markers for PLWH with NSCLC, suggesting immune status may be important in NSCLC survival among PLWH. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of AIDS Care is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=158669741 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/09540121.2021.1934380 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 1014 Subjects: – SubjectFull: Lung cancer complications Type: general – SubjectFull: HIV infection prognosis Type: general – SubjectFull: Lung cancer diagnosis Type: general – SubjectFull: HIV-positive persons Type: general – SubjectFull: HIV infections Type: general – SubjectFull: Biomarkers Type: general – SubjectFull: Confidence intervals Type: general – SubjectFull: Viral load Type: general – SubjectFull: Cancer patients Type: general – SubjectFull: CD4 lymphocyte count Type: general Titles: – TitleFull: The associations of CD4 count, CD4/CD8 ratio, and HIV viral load with survival from non-small cell lung cancer in persons living with HIV. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Klugman, M. – PersonEntity: Name: NameFull: Fazzari, M. – PersonEntity: Name: NameFull: Xue, X. – PersonEntity: Name: NameFull: Ginsberg, M. – PersonEntity: Name: NameFull: Rohan, T. E. – PersonEntity: Name: NameFull: Halmos, B. – PersonEntity: Name: NameFull: Hanna, D. B. – PersonEntity: Name: NameFull: Shuter, J. – PersonEntity: Name: NameFull: Hosgood III, H. D. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 09540121 Numbering: – Type: volume Value: 34 – Type: issue Value: 8 Titles: – TitleFull: AIDS Care Type: main |
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