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Neuropathological studies of serotonergic and noradrenergic systems in Lewy body disease patients with delusion or depression.

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Title: Neuropathological studies of serotonergic and noradrenergic systems in Lewy body disease patients with delusion or depression.
Authors: Mizutani, Masashi (AUTHOR), Sano, Terunori (AUTHOR), Ohira, Masayuki (AUTHOR), Takao, Masaki (AUTHOR)
Source: Psychiatry & Clinical Neurosciences. Sep2022, Vol. 76 Issue 9, p459-467. 9p. 3 Charts, 5 Graphs.
Subjects: Delusions, Mental depression, Raphe nuclei, Locus coeruleus, Prefrontal cortex, Neurons, Serotonin syndrome
Abstract: Aim: The association between psychiatric symptoms in Lewy body disease (LBD) and the noradrenergic and serotonergic systems is still controversial. This study investigated the quantitative relationships of depression and delusion with these systems. Methods: We studied 24 postmortem tissues from individuals with a pathological diagnosis of LBD with sufficient clinical history. The numbers of neurons and Lewy bodies (LBs) in the locus coeruleus (LC) and dorsal raphe nucleus (DRN) were counted, and the density of neurons in the DRN was analyzed. In addition, the densities of tryptophan hydroxylase‐positive neurites and norepinephrine transporter‐positive neurites in the amygdala and dorsal prefrontal cortex were measured. Finally, we divided the cases into two groups: with or without depressive mood, and with or without delusion. Quantitative histological data were compared between the groups. Results: The group with depressive mood had a significantly smaller number of neurons in the LC compared with the group without depressive mood. The group with delusion had a significantly larger number of LBs in the DRN compared with the group without delusion. The density of norepinephrine transporter‐positive neurites in the dorsal prefrontal cortex was significantly correlated with the number of neurons in the LC. Conclusions: The accumulation of LBs in the DRN of individuals with LBD was associated with delusion, whereas a decrease in the number of neurons in the LC was associated with depressive mood. These neurodegenerative changes involved the serotonergic and noradrenergic systems and may be associated with the formation of delusion and depression, respectively, in LBD. [ABSTRACT FROM AUTHOR]
Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Neuropathological studies of serotonergic and noradrenergic systems in Lewy body disease patients with delusion or depression.
– Name: Author
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  Data: <searchLink fieldCode="AR" term="%22Mizutani%2C+Masashi%22">Mizutani, Masashi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sano%2C+Terunori%22">Sano, Terunori</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ohira%2C+Masayuki%22">Ohira, Masayuki</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Takao%2C+Masaki%22">Takao, Masaki</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Psychiatry+%26+Clinical+Neurosciences%22">Psychiatry & Clinical Neurosciences</searchLink>. Sep2022, Vol. 76 Issue 9, p459-467. 9p. 3 Charts, 5 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Delusions%22">Delusions</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Raphe+nuclei%22">Raphe nuclei</searchLink><br /><searchLink fieldCode="DE" term="%22Locus+coeruleus%22">Locus coeruleus</searchLink><br /><searchLink fieldCode="DE" term="%22Prefrontal+cortex%22">Prefrontal cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Neurons%22">Neurons</searchLink><br /><searchLink fieldCode="DE" term="%22Serotonin+syndrome%22">Serotonin syndrome</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Aim: The association between psychiatric symptoms in Lewy body disease (LBD) and the noradrenergic and serotonergic systems is still controversial. This study investigated the quantitative relationships of depression and delusion with these systems. Methods: We studied 24 postmortem tissues from individuals with a pathological diagnosis of LBD with sufficient clinical history. The numbers of neurons and Lewy bodies (LBs) in the locus coeruleus (LC) and dorsal raphe nucleus (DRN) were counted, and the density of neurons in the DRN was analyzed. In addition, the densities of tryptophan hydroxylase‐positive neurites and norepinephrine transporter‐positive neurites in the amygdala and dorsal prefrontal cortex were measured. Finally, we divided the cases into two groups: with or without depressive mood, and with or without delusion. Quantitative histological data were compared between the groups. Results: The group with depressive mood had a significantly smaller number of neurons in the LC compared with the group without depressive mood. The group with delusion had a significantly larger number of LBs in the DRN compared with the group without delusion. The density of norepinephrine transporter‐positive neurites in the dorsal prefrontal cortex was significantly correlated with the number of neurons in the LC. Conclusions: The accumulation of LBs in the DRN of individuals with LBD was associated with delusion, whereas a decrease in the number of neurons in the LC was associated with depressive mood. These neurodegenerative changes involved the serotonergic and noradrenergic systems and may be associated with the formation of delusion and depression, respectively, in LBD. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/pcn.13436
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      – Code: eng
        Text: English
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        PageCount: 9
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      – SubjectFull: Delusions
        Type: general
      – SubjectFull: Mental depression
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      – SubjectFull: Raphe nuclei
        Type: general
      – SubjectFull: Locus coeruleus
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      – SubjectFull: Prefrontal cortex
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      – SubjectFull: Neurons
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      – SubjectFull: Serotonin syndrome
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      – TitleFull: Neuropathological studies of serotonergic and noradrenergic systems in Lewy body disease patients with delusion or depression.
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            NameFull: Mizutani, Masashi
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            – D: 01
              M: 09
              Text: Sep2022
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              Y: 2022
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