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Impact of adjuvant therapy on survival for sinonasal mucosal melanoma.

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Title: Impact of adjuvant therapy on survival for sinonasal mucosal melanoma.
Authors: Yuting Lai, Xinjun Meng, Quan Liu, Hanyu Lu, Limin Guo, Shuyi Wang, Dehui Wang
Source: Acta Oto-Laryngologica (Supplement). 2020, Vol. 140 Issue 1, p79-84. 6p. 5 Charts, 4 Graphs.
Subjects: Adjuvant chemotherapy, Confidence intervals, Melanoma, Operative surgery, Cancer chemotherapy, Log-rank test, Paranasal sinus cancer, Retrospective studies, Metastasis, Adjuvant treatment of cancer, Chemoradiotherapy, Treatment effectiveness, Comparative studies, Kaplan-Meier estimator, Descriptive statistics, Progression-free survival, Radiotherapy, Odds ratio
Abstract: Background: The optimal treatment modality for sinonasal mucosal melanoma (SNMM) remains controversial. Objectives: To investigate the impact of adjuvant therapy on SNMM. Material and methods: Ninety-two patients were retrospectively analyzed and were grouped into surgery alone (SA), surgery plus radiotherapy (SR), surgery plus chemotherapy (SC) and surgery plus radiochemotherapy (SRC) groups. Survival outcomes among different treatment modalities were analyzed using the Kaplan–Meier method and log-rank test. Results: Twenty-nine patients (31.5%) developed local recurrence, 10 patients (10.9%) had nodal metastasis, and 41 patients (44.6%) had distant metastasis. The overall survival time (OS) for SA, SR and SRC were 16, 29 and 27 months, respectively, and the disease-free survival time (DFS) were 10, 16 and 16 months, respectively. Significant differences were found between SA and SR (OS: p= .003; DFS: p = .016) and SA and SRC (OS: p = .002; DFS: p = .008). Superior outcomes were also found in SRC group compared to that in SA group for both OS (15 vs. 27 months, p = .012) and DFS (10 vs. 20 months, p =.017) in endoscopic approach. Conclusions and significance: SNMM had poor prognosis with high rates of local recurrence and metastasis. Adjuvant therapy improved survival outcomes for SNMM. [ABSTRACT FROM AUTHOR]
Copyright of Acta Oto-Laryngologica (Supplement) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Group: Ti
  Data: Impact of adjuvant therapy on survival for sinonasal mucosal melanoma.
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  Data: <searchLink fieldCode="AR" term="%22Yuting+Lai%22">Yuting Lai</searchLink><br /><searchLink fieldCode="AR" term="%22Xinjun+Meng%22">Xinjun Meng</searchLink><br /><searchLink fieldCode="AR" term="%22Quan+Liu%22">Quan Liu</searchLink><br /><searchLink fieldCode="AR" term="%22Hanyu+Lu%22">Hanyu Lu</searchLink><br /><searchLink fieldCode="AR" term="%22Limin+Guo%22">Limin Guo</searchLink><br /><searchLink fieldCode="AR" term="%22Shuyi+Wang%22">Shuyi Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Dehui+Wang%22">Dehui Wang</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Acta+Oto-Laryngologica+%28Supplement%29%22">Acta Oto-Laryngologica (Supplement)</searchLink>. 2020, Vol. 140 Issue 1, p79-84. 6p. 5 Charts, 4 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Adjuvant+chemotherapy%22">Adjuvant chemotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Melanoma%22">Melanoma</searchLink><br /><searchLink fieldCode="DE" term="%22Operative+surgery%22">Operative surgery</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+chemotherapy%22">Cancer chemotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Log-rank+test%22">Log-rank test</searchLink><br /><searchLink fieldCode="DE" term="%22Paranasal+sinus+cancer%22">Paranasal sinus cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Retrospective+studies%22">Retrospective studies</searchLink><br /><searchLink fieldCode="DE" term="%22Metastasis%22">Metastasis</searchLink><br /><searchLink fieldCode="DE" term="%22Adjuvant+treatment+of+cancer%22">Adjuvant treatment of cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Chemoradiotherapy%22">Chemoradiotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Kaplan-Meier+estimator%22">Kaplan-Meier estimator</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Progression-free+survival%22">Progression-free survival</searchLink><br /><searchLink fieldCode="DE" term="%22Radiotherapy%22">Radiotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Odds+ratio%22">Odds ratio</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: The optimal treatment modality for sinonasal mucosal melanoma (SNMM) remains controversial. Objectives: To investigate the impact of adjuvant therapy on SNMM. Material and methods: Ninety-two patients were retrospectively analyzed and were grouped into surgery alone (SA), surgery plus radiotherapy (SR), surgery plus chemotherapy (SC) and surgery plus radiochemotherapy (SRC) groups. Survival outcomes among different treatment modalities were analyzed using the Kaplan–Meier method and log-rank test. Results: Twenty-nine patients (31.5%) developed local recurrence, 10 patients (10.9%) had nodal metastasis, and 41 patients (44.6%) had distant metastasis. The overall survival time (OS) for SA, SR and SRC were 16, 29 and 27 months, respectively, and the disease-free survival time (DFS) were 10, 16 and 16 months, respectively. Significant differences were found between SA and SR (OS: p= .003; DFS: p = .016) and SA and SRC (OS: p = .002; DFS: p = .008). Superior outcomes were also found in SRC group compared to that in SA group for both OS (15 vs. 27 months, p = .012) and DFS (10 vs. 20 months, p =.017) in endoscopic approach. Conclusions and significance: SNMM had poor prognosis with high rates of local recurrence and metastasis. Adjuvant therapy improved survival outcomes for SNMM. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Oto-Laryngologica (Supplement) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/00016489.2019.1635269
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 6
        StartPage: 79
    Subjects:
      – SubjectFull: Adjuvant chemotherapy
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Melanoma
        Type: general
      – SubjectFull: Operative surgery
        Type: general
      – SubjectFull: Cancer chemotherapy
        Type: general
      – SubjectFull: Log-rank test
        Type: general
      – SubjectFull: Paranasal sinus cancer
        Type: general
      – SubjectFull: Retrospective studies
        Type: general
      – SubjectFull: Metastasis
        Type: general
      – SubjectFull: Adjuvant treatment of cancer
        Type: general
      – SubjectFull: Chemoradiotherapy
        Type: general
      – SubjectFull: Treatment effectiveness
        Type: general
      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Kaplan-Meier estimator
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      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Progression-free survival
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      – SubjectFull: Radiotherapy
        Type: general
      – SubjectFull: Odds ratio
        Type: general
    Titles:
      – TitleFull: Impact of adjuvant therapy on survival for sinonasal mucosal melanoma.
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            NameFull: Yuting Lai
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              Text: 2020
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              Y: 2020
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