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Human tissue lead (Pb) levels and amyotrophic lateral sclerosis: a systematic review and meta-analysis of case-control studies.

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Title: Human tissue lead (Pb) levels and amyotrophic lateral sclerosis: a systematic review and meta-analysis of case-control studies.
Authors: Farace, Cristiano (AUTHOR), Fiorito, Giovanni (AUTHOR), Pisano, Andrea (AUTHOR), Etzi, Federica (AUTHOR), Sabalic, Angela (AUTHOR), Fenu, Grazia (AUTHOR), Asara, Yolande (AUTHOR), Solinas, Giuliana (AUTHOR), Madeddu, Roberto (AUTHOR)
Source: Neurological Sciences. Oct2022, Vol. 43 Issue 10, p5851-5859. 9p. 4 Diagrams, 1 Chart, 1 Graph.
Subjects: Meta-analysis, Systematic reviews, Case-control method, Amyotrophic lateral sclerosis, Research funding, Lead
Abstract: Aim: To combine the current scientific literature evidence and elucidate the differences of lead (Pb) bioaccumulation in human tissues by comparing amyotrophic lateral sclerosis (ALS) patients and healthy controls.Methods: We systematically searched for case-control studies on the association of Pb levels with ALS, in human cells, tissues, and body fluids (nervous tissue, muscle, blood, cerebrospinal fluid, urine, skin appendages). Then, we performed a meta-analysis for all the tissues in which at least five case-control studies were available: whole blood (9 studies), serum/plasma (5 studies), and cerebrospinal fluid (CSF) (6 studies). Differences between cases and controls were evaluated using standardized mean difference, and combined estimates were derived using random effect maximum likelihood (REML) meta-analyses.Results: Among 1734 records, we identified 46 full-text studies, of which 14 case-control studies met the meta-analysis inclusion criteria. We found higher Pb levels in ALS cases than controls in blood (standardized mean difference (SMD) = 0.61; 95% confidence interval (CI) 0.20, 1.01; p = 0.003), plasma/serum (SMD = 0.27; 95% CI - 0.16, 0.70; p = 0.26), and CSF (SMD = 0.53; 95% CI - 0.09, 1.15; p = 0.09).Conclusions: This work provides further evidence of the association between Pb bioaccumulation and ALS in body fluids. The lack of association studies in solid tissues did not allow a robust meta-analysis. Future prospective studies are needed to clarify the causality in the association of Pb bioaccumulation with ALS. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Human tissue lead (Pb) levels and amyotrophic lateral sclerosis: a systematic review and meta-analysis of case-control studies.
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  Data: <searchLink fieldCode="AR" term="%22Farace%2C+Cristiano%22">Farace, Cristiano</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fiorito%2C+Giovanni%22">Fiorito, Giovanni</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pisano%2C+Andrea%22">Pisano, Andrea</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Etzi%2C+Federica%22">Etzi, Federica</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sabalic%2C+Angela%22">Sabalic, Angela</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fenu%2C+Grazia%22">Fenu, Grazia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Asara%2C+Yolande%22">Asara, Yolande</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Solinas%2C+Giuliana%22">Solinas, Giuliana</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Madeddu%2C+Roberto%22">Madeddu, Roberto</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Oct2022, Vol. 43 Issue 10, p5851-5859. 9p. 4 Diagrams, 1 Chart, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Meta-analysis%22">Meta-analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Systematic+reviews%22">Systematic reviews</searchLink><br /><searchLink fieldCode="DE" term="%22Case-control+method%22">Case-control method</searchLink><br /><searchLink fieldCode="DE" term="%22Amyotrophic+lateral+sclerosis%22">Amyotrophic lateral sclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Lead%22">Lead</searchLink>
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  Data: <bold>Aim: </bold>To combine the current scientific literature evidence and elucidate the differences of lead (Pb) bioaccumulation in human tissues by comparing amyotrophic lateral sclerosis (ALS) patients and healthy controls.<bold>Methods: </bold>We systematically searched for case-control studies on the association of Pb levels with ALS, in human cells, tissues, and body fluids (nervous tissue, muscle, blood, cerebrospinal fluid, urine, skin appendages). Then, we performed a meta-analysis for all the tissues in which at least five case-control studies were available: whole blood (9 studies), serum/plasma (5 studies), and cerebrospinal fluid (CSF) (6 studies). Differences between cases and controls were evaluated using standardized mean difference, and combined estimates were derived using random effect maximum likelihood (REML) meta-analyses.<bold>Results: </bold>Among 1734 records, we identified 46 full-text studies, of which 14 case-control studies met the meta-analysis inclusion criteria. We found higher Pb levels in ALS cases than controls in blood (standardized mean difference (SMD) = 0.61; 95% confidence interval (CI) 0.20, 1.01; p = 0.003), plasma/serum (SMD = 0.27; 95% CI - 0.16, 0.70; p = 0.26), and CSF (SMD = 0.53; 95% CI - 0.09, 1.15; p = 0.09).<bold>Conclusions: </bold>This work provides further evidence of the association between Pb bioaccumulation and ALS in body fluids. The lack of association studies in solid tissues did not allow a robust meta-analysis. Future prospective studies are needed to clarify the causality in the association of Pb bioaccumulation with ALS. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10072-022-06237-y
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