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In silico gene expression and pathway analysis of DEK in the human brain across the lifespan.

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Title: In silico gene expression and pathway analysis of DEK in the human brain across the lifespan.
Authors: Greene, Allie N. (AUTHOR), Nguyen, Elizabeth T. (AUTHOR), Paranjpe, Aditi (AUTHOR), Lane, Adam (AUTHOR), Privette Vinnedge, Lisa M. (AUTHOR), Solomon, Matia B. (AUTHOR)
Source: European Journal of Neuroscience. Sep2022, Vol. 56 Issue 6, p4720-4743. 24p. 3 Diagrams, 8 Charts, 2 Graphs.
Subjects: Neural transmission, Gene expression, Alzheimer's disease, Central nervous system diseases, Older people, Fetal development
Abstract: DEK, a chromatin‐remodelling phosphoprotein, is associated with various functions and biological pathways in the periphery, including inflammation, oncogenesis, DNA repair, and transcriptional regulation. We recently identified an association between DEK loss and central nervous system diseases, such as Alzheimer's. To understand DEK's potential role in disease, it is critical to characterize DEK in healthy human brain to distinguish between neural DEK expression and function in healthy versus diseased states like dementia. We utilized two public databases, BrainCloud and Human Brain Transcriptome, and analysed DEK mRNA expression across the lifespan in learning and memory relevant brain regions. Since DEK loss induces phenotypes associated with brain ageing (e.g., DNA damage and apoptosis), we hypothesized that neural DEK expression may be highest during foetal development and lower in elderly individuals. In agreement with this hypothesis, DEK was most prominently expressed during foetal development in all queried forebrain areas, relative to other ages. Consistent with its roles in the periphery, pathways related to DEK in the brain were associated with cellular proliferation, DNA replication and repair, apoptosis, and inflammation. We also found novel neural development‐relevant pathways (e.g., synaptic transmission, neurite outgrowth, and myelination) to be enriched from genes correlated with DEK expression. These findings suggest that DEK is important for human brain development. Overall, we highlight age‐related changes in neural DEK expression across the human lifespan and illuminate novel biological pathways associated with DEK that are distinct from normal brain ageing. These findings may further our understanding of how DEK impacts brain function and disease susceptibility. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: In silico gene expression and pathway analysis of DEK in the human brain across the lifespan.
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  Data: <searchLink fieldCode="AR" term="%22Greene%2C+Allie+N%2E%22">Greene, Allie N.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nguyen%2C+Elizabeth+T%2E%22">Nguyen, Elizabeth T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Paranjpe%2C+Aditi%22">Paranjpe, Aditi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lane%2C+Adam%22">Lane, Adam</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Privette+Vinnedge%2C+Lisa+M%2E%22">Privette Vinnedge, Lisa M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Solomon%2C+Matia+B%2E%22">Solomon, Matia B.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Sep2022, Vol. 56 Issue 6, p4720-4743. 24p. 3 Diagrams, 8 Charts, 2 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Neural+transmission%22">Neural transmission</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+expression%22">Gene expression</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+disease%22">Alzheimer's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Central+nervous+system+diseases%22">Central nervous system diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Older+people%22">Older people</searchLink><br /><searchLink fieldCode="DE" term="%22Fetal+development%22">Fetal development</searchLink>
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  Label: Abstract
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  Data: DEK, a chromatin‐remodelling phosphoprotein, is associated with various functions and biological pathways in the periphery, including inflammation, oncogenesis, DNA repair, and transcriptional regulation. We recently identified an association between DEK loss and central nervous system diseases, such as Alzheimer's. To understand DEK's potential role in disease, it is critical to characterize DEK in healthy human brain to distinguish between neural DEK expression and function in healthy versus diseased states like dementia. We utilized two public databases, BrainCloud and Human Brain Transcriptome, and analysed DEK mRNA expression across the lifespan in learning and memory relevant brain regions. Since DEK loss induces phenotypes associated with brain ageing (e.g., DNA damage and apoptosis), we hypothesized that neural DEK expression may be highest during foetal development and lower in elderly individuals. In agreement with this hypothesis, DEK was most prominently expressed during foetal development in all queried forebrain areas, relative to other ages. Consistent with its roles in the periphery, pathways related to DEK in the brain were associated with cellular proliferation, DNA replication and repair, apoptosis, and inflammation. We also found novel neural development‐relevant pathways (e.g., synaptic transmission, neurite outgrowth, and myelination) to be enriched from genes correlated with DEK expression. These findings suggest that DEK is important for human brain development. Overall, we highlight age‐related changes in neural DEK expression across the human lifespan and illuminate novel biological pathways associated with DEK that are distinct from normal brain ageing. These findings may further our understanding of how DEK impacts brain function and disease susceptibility. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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