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Risk of hospitalization and death for COVID‐19 in persons with epilepsy over a 20‐month period: The EpiLink Bologna cohort, Italy.

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Title: Risk of hospitalization and death for COVID‐19 in persons with epilepsy over a 20‐month period: The EpiLink Bologna cohort, Italy.
Authors: Muccioli, Lorenzo (AUTHOR), Zenesini, Corrado (AUTHOR), Taruffi, Lisa (AUTHOR), Licchetta, Laura (AUTHOR), Mostacci, Barbara (AUTHOR), Di Vito, Lidia (AUTHOR), Pasini, Elena (AUTHOR), Volpi, Lilia (AUTHOR), Riguzzi, Patrizia (AUTHOR), Ferri, Lorenzo (AUTHOR), Baccari, Flavia (AUTHOR), Nonino, Francesco (AUTHOR), Michelucci, Roberto (AUTHOR), Tinuper, Paolo (AUTHOR), Vignatelli, Luca (AUTHOR), Bisulli, Francesca (AUTHOR)
Source: Epilepsia (Series 4). Sep2022, Vol. 63 Issue 9, p2279-2289. 11p.
Subjects: People with epilepsy, COVID-19, Partial epilepsy, Hospital care, COVID-19 pandemic
Geographic Terms: Bologna (Italy), Italy
Abstract: Objective: Data on COVID‐19 outcomes in persons with epilepsy (PWE) are scarce and inconclusive. We aimed to study the risk of hospitalization and death for COVID‐19 in a large cohort of PWE from March 1, 2020 to October 31, 2021. Methods: The historical cohort design (EpiLink Bologna) compared adult PWE grouped into people with focal epilepsy (PFE), idiopathic generalized epilepsy (PIGE), and developmental and/or epileptic encephalopathy (PDEE), and a population cohort matched (ratio 1:10) for age, sex, residence, and comorbidity (assessed with the multisource comorbidity score), living in the local health trust of Bologna (approximately 800 000 residents). Clinical data were linked to health administrative data. Results: In both cohorts (EpiLink: n = 1575 subjects, 1128 PFE, 267 PIGE, 148 PDEE, 32 other; controls: n = 15 326 subjects), 52% were females, and the mean age was 50 years (SD = 18). Hospital admissions for COVID‐19 in the whole period were 49 (3.1%) in PWE and 225 (1.5%) in controls. The adjusted hazard ratio (aHR) in PWE was 1.9 (95% confidence interval [CI] = 1.4–2.7). The subgroups at higher risk were PFE (aHR = 1.9, 95% CI = 1.3–2.8) and PDEE (aHR = 3.9, 95% CI = 1.7–8.7), whereas PIGE had a risk comparable to the controls (aHR = 1.1, 95% CI =.3–3.5). Stratified analyses of the two main epidemic waves (March–May 2020, October 2020–May 2021) disclosed a higher risk of COVID‐19‐related hospitalization during the first epidemic wave (March–May 2020; aHR = 3.8, 95% CI = 2.2–6.7). Polytherapy with antiseizure medications contributed to a higher risk of hospital admission. Thirty‐day risk of death after hospitalization was 14% in both PWE and controls. Significance: During the first 20 months since the outbreak of COVID‐19 in Bologna, PWE had a doubled risk of COVID‐19 hospital admission compared to a matched control population. Conversely, epilepsy did not represent a risk factor for COVID‐19‐related death. [ABSTRACT FROM AUTHOR]
Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
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  Data: Risk of hospitalization and death for COVID‐19 in persons with epilepsy over a 20‐month period: The EpiLink Bologna cohort, Italy.
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  Data: <searchLink fieldCode="AR" term="%22Muccioli%2C+Lorenzo%22">Muccioli, Lorenzo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zenesini%2C+Corrado%22">Zenesini, Corrado</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Taruffi%2C+Lisa%22">Taruffi, Lisa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Licchetta%2C+Laura%22">Licchetta, Laura</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mostacci%2C+Barbara%22">Mostacci, Barbara</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Di+Vito%2C+Lidia%22">Di Vito, Lidia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pasini%2C+Elena%22">Pasini, Elena</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Volpi%2C+Lilia%22">Volpi, Lilia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Riguzzi%2C+Patrizia%22">Riguzzi, Patrizia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ferri%2C+Lorenzo%22">Ferri, Lorenzo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Baccari%2C+Flavia%22">Baccari, Flavia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nonino%2C+Francesco%22">Nonino, Francesco</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Michelucci%2C+Roberto%22">Michelucci, Roberto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tinuper%2C+Paolo%22">Tinuper, Paolo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vignatelli%2C+Luca%22">Vignatelli, Luca</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bisulli%2C+Francesca%22">Bisulli, Francesca</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Epilepsia+%28Series+4%29%22">Epilepsia (Series 4)</searchLink>. Sep2022, Vol. 63 Issue 9, p2279-2289. 11p.
– Name: Subject
  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22People+with+epilepsy%22">People with epilepsy</searchLink><br /><searchLink fieldCode="DE" term="%22COVID-19%22">COVID-19</searchLink><br /><searchLink fieldCode="DE" term="%22Partial+epilepsy%22">Partial epilepsy</searchLink><br /><searchLink fieldCode="DE" term="%22Hospital+care%22">Hospital care</searchLink><br /><searchLink fieldCode="DE" term="%22COVID-19+pandemic%22">COVID-19 pandemic</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Bologna+%28Italy%29%22">Bologna (Italy)</searchLink><br /><searchLink fieldCode="DE" term="%22Italy%22">Italy</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: Data on COVID‐19 outcomes in persons with epilepsy (PWE) are scarce and inconclusive. We aimed to study the risk of hospitalization and death for COVID‐19 in a large cohort of PWE from March 1, 2020 to October 31, 2021. Methods: The historical cohort design (EpiLink Bologna) compared adult PWE grouped into people with focal epilepsy (PFE), idiopathic generalized epilepsy (PIGE), and developmental and/or epileptic encephalopathy (PDEE), and a population cohort matched (ratio 1:10) for age, sex, residence, and comorbidity (assessed with the multisource comorbidity score), living in the local health trust of Bologna (approximately 800 000 residents). Clinical data were linked to health administrative data. Results: In both cohorts (EpiLink: n = 1575 subjects, 1128 PFE, 267 PIGE, 148 PDEE, 32 other; controls: n = 15 326 subjects), 52% were females, and the mean age was 50 years (SD = 18). Hospital admissions for COVID‐19 in the whole period were 49 (3.1%) in PWE and 225 (1.5%) in controls. The adjusted hazard ratio (aHR) in PWE was 1.9 (95% confidence interval [CI] = 1.4–2.7). The subgroups at higher risk were PFE (aHR = 1.9, 95% CI = 1.3–2.8) and PDEE (aHR = 3.9, 95% CI = 1.7–8.7), whereas PIGE had a risk comparable to the controls (aHR = 1.1, 95% CI =.3–3.5). Stratified analyses of the two main epidemic waves (March–May 2020, October 2020–May 2021) disclosed a higher risk of COVID‐19‐related hospitalization during the first epidemic wave (March–May 2020; aHR = 3.8, 95% CI = 2.2–6.7). Polytherapy with antiseizure medications contributed to a higher risk of hospital admission. Thirty‐day risk of death after hospitalization was 14% in both PWE and controls. Significance: During the first 20 months since the outbreak of COVID‐19 in Bologna, PWE had a doubled risk of COVID‐19 hospital admission compared to a matched control population. Conversely, epilepsy did not represent a risk factor for COVID‐19‐related death. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1111/epi.17356
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      – Code: eng
        Text: English
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      – SubjectFull: People with epilepsy
        Type: general
      – SubjectFull: COVID-19
        Type: general
      – SubjectFull: Partial epilepsy
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      – SubjectFull: Hospital care
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      – SubjectFull: COVID-19 pandemic
        Type: general
      – SubjectFull: Bologna (Italy)
        Type: general
      – SubjectFull: Italy
        Type: general
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      – TitleFull: Risk of hospitalization and death for COVID‐19 in persons with epilepsy over a 20‐month period: The EpiLink Bologna cohort, Italy.
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              Text: Sep2022
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