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Specialized inpatient treatment for young people with early psychosis: acute-treatment and 12-month results.

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Title: Specialized inpatient treatment for young people with early psychosis: acute-treatment and 12-month results.
Authors: Siebert, Stefan (AUTHOR), Leopold, Karolina (AUTHOR), Baumgardt, Johanna (AUTHOR), von Hardenberg, Laura-Sophie (AUTHOR), Burkhardt, Eva (AUTHOR), Bechdolf, Andreas (AUTHOR)
Source: European Archives of Psychiatry & Clinical Neuroscience. Oct2022, Vol. 272 Issue 7, p1-14. 14p. 4 Charts.
Subjects: Young adults, Termination of treatment, Psychoses, Patient satisfaction, People with mental illness
Geographic Terms: Berlin (Germany)
Abstract: The objective of the study was to investigate the development of clinical outcomes of young people with early psychosis in a specialized inpatient treatment and assess the feasibility of such an intervention in an inpatient setting. The study was a prospective cohort study of patients with early psychosis treated at the specialized inpatient treatment "Fühinterventions-und Therapiezentrum, FRITZ" (early intervention and therapy center) in Berlin, Germany. The primary outcomes were attitudes towards psychiatric medication and patient satisfaction with treatment after 6 weeks. Secondary outcomes were clinical symptoms, functioning, remission, recovery, all-cause treatment discontinuation, and rehospitalisation at 6 and 12 months after inpatient treatment. We recruited 95 inpatients with early psychosis. Attitudes towards psychiatric medication (Δ6weeks = 3.00, d6weeks = 0.55; Δ6mo = 2.15, d6mo = 0.35; Δ12mo = 3.03, d12mo = 0.52) and patient satisfaction (Δ6weeks = 0.21, d6weeks = 0.40; Δ6mo = 0.32, d6mo = 0.43; Δ12mo = 0.13, d12mo = 0.17) changed with medium effect sizes at six weeks up to a 6- and 12-month follow-up. Clinical outcomes changed significantly with medium-to-large-effect sizes over 12 months CGIΔ12mo = 1.64, d12mo = −1.12; PANSS totalΔ12mo = 20.10, d12mo = −0.76; GAFΔ12mo = 19.58, d12mo = 1.25). The all-cause treatment discontinuation rate was 13.69% (n = 13) at a 6-month and 35.79% (n = 34) at a 12-month follow-up. The rehospitalization rate was 30.53% (n = 29) at a 6-month and 43.16% (n = 41) at a 12-month follow-up. Patients with specialized inpatient treatment for early psychosis showed improvements in attitude towards psychiatric medication, patient satisfaction, symptoms, and functioning for up to 12 months. Trial registration: DRKS00024351, 2021/02/11 retrospectively registered. [ABSTRACT FROM AUTHOR]
Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Specialized inpatient treatment for young people with early psychosis: acute-treatment and 12-month results.
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  Data: <searchLink fieldCode="AR" term="%22Siebert%2C+Stefan%22">Siebert, Stefan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Leopold%2C+Karolina%22">Leopold, Karolina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Baumgardt%2C+Johanna%22">Baumgardt, Johanna</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22von+Hardenberg%2C+Laura-Sophie%22">von Hardenberg, Laura-Sophie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Burkhardt%2C+Eva%22">Burkhardt, Eva</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bechdolf%2C+Andreas%22">Bechdolf, Andreas</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Oct2022, Vol. 272 Issue 7, p1-14. 14p. 4 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Young+adults%22">Young adults</searchLink><br /><searchLink fieldCode="DE" term="%22Termination+of+treatment%22">Termination of treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Psychoses%22">Psychoses</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+satisfaction%22">Patient satisfaction</searchLink><br /><searchLink fieldCode="DE" term="%22People+with+mental+illness%22">People with mental illness</searchLink>
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  Data: The objective of the study was to investigate the development of clinical outcomes of young people with early psychosis in a specialized inpatient treatment and assess the feasibility of such an intervention in an inpatient setting. The study was a prospective cohort study of patients with early psychosis treated at the specialized inpatient treatment "Fühinterventions-und Therapiezentrum, FRITZ" (early intervention and therapy center) in Berlin, Germany. The primary outcomes were attitudes towards psychiatric medication and patient satisfaction with treatment after 6 weeks. Secondary outcomes were clinical symptoms, functioning, remission, recovery, all-cause treatment discontinuation, and rehospitalisation at 6 and 12 months after inpatient treatment. We recruited 95 inpatients with early psychosis. Attitudes towards psychiatric medication (Δ6weeks = 3.00, d6weeks = 0.55; Δ6mo = 2.15, d6mo = 0.35; Δ12mo = 3.03, d12mo = 0.52) and patient satisfaction (Δ6weeks = 0.21, d6weeks = 0.40; Δ6mo = 0.32, d6mo = 0.43; Δ12mo = 0.13, d12mo = 0.17) changed with medium effect sizes at six weeks up to a 6- and 12-month follow-up. Clinical outcomes changed significantly with medium-to-large-effect sizes over 12 months CGIΔ12mo = 1.64, d12mo = −1.12; PANSS totalΔ12mo = 20.10, d12mo = −0.76; GAFΔ12mo = 19.58, d12mo = 1.25). The all-cause treatment discontinuation rate was 13.69% (n = 13) at a 6-month and 35.79% (n = 34) at a 12-month follow-up. The rehospitalization rate was 30.53% (n = 29) at a 6-month and 43.16% (n = 41) at a 12-month follow-up. Patients with specialized inpatient treatment for early psychosis showed improvements in attitude towards psychiatric medication, patient satisfaction, symptoms, and functioning for up to 12 months. Trial registration: DRKS00024351, 2021/02/11 retrospectively registered. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00406-022-01379-8
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        Text: English
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      – SubjectFull: Young adults
        Type: general
      – SubjectFull: Termination of treatment
        Type: general
      – SubjectFull: Psychoses
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      – SubjectFull: Patient satisfaction
        Type: general
      – SubjectFull: People with mental illness
        Type: general
      – SubjectFull: Berlin (Germany)
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      – TitleFull: Specialized inpatient treatment for young people with early psychosis: acute-treatment and 12-month results.
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              M: 10
              Text: Oct2022
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              Y: 2022
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              Value: 272
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