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Cannabinoids modulate proliferation, differentiation, and migration signaling pathways in oligodendrocytes.

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Title: Cannabinoids modulate proliferation, differentiation, and migration signaling pathways in oligodendrocytes.
Authors: de Almeida, Valéria (AUTHOR), Seabra, Gabriela (AUTHOR), Reis-de-Oliveira, Guilherme (AUTHOR), Zuccoli, Giuliana S. (AUTHOR), Rumin, Priscila (AUTHOR), Fioramonte, Mariana (AUTHOR), Smith, Bradley J. (AUTHOR), Zuardi, Antonio W. (AUTHOR), Hallak, Jaime E. C. (AUTHOR), Campos, Alline C. (AUTHOR), Crippa, José A. (AUTHOR), Martins-de-Souza, Daniel (AUTHOR)
Source: European Archives of Psychiatry & Clinical Neuroscience. Oct2022, Vol. 272 Issue 7, p1311-1323. 13p. 1 Color Photograph, 1 Diagram, 1 Chart, 2 Graphs.
Subjects: Cannabinoids, Cellular signal transduction, Oligodendroglia, Lipid metabolism, Cannabidiol
Geographic Terms: Tripoli (Libya)
Abstract: Cannabinoid signaling, mainly via CB1 and CB2 receptors, plays an essential role in oligodendrocyte health and functions. However, the specific molecular signals associated with the activation or blockade of CB1 and CB2 receptors in this glial cell have yet to be elucidated. Mass spectrometry-based shotgun proteomics and in silico biology tools were used to determine which signaling pathways and molecular mechanisms are triggered in a human oligodendrocytic cell line (MO3.13) by several pharmacological stimuli: the phytocannabinoid cannabidiol (CBD); CB1 and CB2 agonists ACEA, HU308, and WIN55, 212–2; CB1 and CB2 antagonists AM251 and AM630; and endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG). The modulation of cannabinoid signaling in MO3.13 was found to affect pathways linked to cell proliferation, migration, and differentiation of oligodendrocyte progenitor cells. Additionally, we found that carbohydrate and lipid metabolism, as well as mitochondrial function, were modulated by these compounds. Comparing the proteome changes and upstream regulators among treatments, the highest overlap was between the CB1 and CB2 antagonists, followed by overlaps between AEA and 2-AG. Our study opens new windows of opportunities, suggesting that cannabinoid signaling in oligodendrocytes might be relevant in the context of demyelinating and neurodegenerative diseases. Proteomics data are available at ProteomeXchange (PXD031923). [ABSTRACT FROM AUTHOR]
Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Cannabinoids modulate proliferation, differentiation, and migration signaling pathways in oligodendrocytes.
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  Data: <searchLink fieldCode="AR" term="%22de+Almeida%2C+Valéria%22">de Almeida, Valéria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Seabra%2C+Gabriela%22">Seabra, Gabriela</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Reis-de-Oliveira%2C+Guilherme%22">Reis-de-Oliveira, Guilherme</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zuccoli%2C+Giuliana+S%2E%22">Zuccoli, Giuliana S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rumin%2C+Priscila%22">Rumin, Priscila</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fioramonte%2C+Mariana%22">Fioramonte, Mariana</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Smith%2C+Bradley+J%2E%22">Smith, Bradley J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zuardi%2C+Antonio+W%2E%22">Zuardi, Antonio W.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hallak%2C+Jaime+E%2E+C%2E%22">Hallak, Jaime E. C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Campos%2C+Alline+C%2E%22">Campos, Alline C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Crippa%2C+José+A%2E%22">Crippa, José A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Martins-de-Souza%2C+Daniel%22">Martins-de-Souza, Daniel</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Oct2022, Vol. 272 Issue 7, p1311-1323. 13p. 1 Color Photograph, 1 Diagram, 1 Chart, 2 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Cannabinoids%22">Cannabinoids</searchLink><br /><searchLink fieldCode="DE" term="%22Cellular+signal+transduction%22">Cellular signal transduction</searchLink><br /><searchLink fieldCode="DE" term="%22Oligodendroglia%22">Oligodendroglia</searchLink><br /><searchLink fieldCode="DE" term="%22Lipid+metabolism%22">Lipid metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Cannabidiol%22">Cannabidiol</searchLink>
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  Data: Cannabinoid signaling, mainly via CB1 and CB2 receptors, plays an essential role in oligodendrocyte health and functions. However, the specific molecular signals associated with the activation or blockade of CB1 and CB2 receptors in this glial cell have yet to be elucidated. Mass spectrometry-based shotgun proteomics and in silico biology tools were used to determine which signaling pathways and molecular mechanisms are triggered in a human oligodendrocytic cell line (MO3.13) by several pharmacological stimuli: the phytocannabinoid cannabidiol (CBD); CB1 and CB2 agonists ACEA, HU308, and WIN55, 212–2; CB1 and CB2 antagonists AM251 and AM630; and endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG). The modulation of cannabinoid signaling in MO3.13 was found to affect pathways linked to cell proliferation, migration, and differentiation of oligodendrocyte progenitor cells. Additionally, we found that carbohydrate and lipid metabolism, as well as mitochondrial function, were modulated by these compounds. Comparing the proteome changes and upstream regulators among treatments, the highest overlap was between the CB1 and CB2 antagonists, followed by overlaps between AEA and 2-AG. Our study opens new windows of opportunities, suggesting that cannabinoid signaling in oligodendrocytes might be relevant in the context of demyelinating and neurodegenerative diseases. Proteomics data are available at ProteomeXchange (PXD031923). [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00406-022-01425-5
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        Text: English
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      – SubjectFull: Cannabinoids
        Type: general
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      – SubjectFull: Oligodendroglia
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