Awake perception is associated with dedicated neuronal assemblies in the cerebral cortex.
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| Title: | Awake perception is associated with dedicated neuronal assemblies in the cerebral cortex. |
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| Authors: | Filipchuk, Anton (AUTHOR), Schwenkgrub, Joanna (AUTHOR), Destexhe, Alain (AUTHOR), Bathellier, Brice (AUTHOR) |
| Source: | Nature Neuroscience. Oct2022, Vol. 25 Issue 10, p1327-1338. 12p. |
| Abstract: | Neural activity in the sensory cortex combines stimulus responses and ongoing activity, but it remains unclear whether these reflect the same underlying dynamics or separate processes. In the present study, we show in mice that, during wakefulness, the neuronal assemblies evoked by sounds in the auditory cortex and thalamus are specific to the stimulus and distinct from the assemblies observed in ongoing activity. By contrast, under three different anesthetics, evoked assemblies are indistinguishable from ongoing assemblies in the cortex. However, they remain distinct in the thalamus. A strong remapping of sensory responses accompanies this dynamic state change produced by anesthesia. Together, these results show that the awake cortex engages dedicated neuronal assemblies in response to sensory inputs, which we suggest is a network correlate of sensory perception. Filipchuk et al. show that when awake mice perceive sounds, the auditory cortex produces sound-specific neuronal assemblies distinct from its ongoing activity, whereas under anesthesia sound-evoked assemblies are indistinguishable from ongoing activity. [ABSTRACT FROM AUTHOR] |
| Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 159499951 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Awake perception is associated with dedicated neuronal assemblies in the cerebral cortex. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Filipchuk%2C+Anton%22">Filipchuk, Anton</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schwenkgrub%2C+Joanna%22">Schwenkgrub, Joanna</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Destexhe%2C+Alain%22">Destexhe, Alain</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bathellier%2C+Brice%22">Bathellier, Brice</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nature+Neuroscience%22">Nature Neuroscience</searchLink>. Oct2022, Vol. 25 Issue 10, p1327-1338. 12p. – Name: Abstract Label: Abstract Group: Ab Data: Neural activity in the sensory cortex combines stimulus responses and ongoing activity, but it remains unclear whether these reflect the same underlying dynamics or separate processes. In the present study, we show in mice that, during wakefulness, the neuronal assemblies evoked by sounds in the auditory cortex and thalamus are specific to the stimulus and distinct from the assemblies observed in ongoing activity. By contrast, under three different anesthetics, evoked assemblies are indistinguishable from ongoing assemblies in the cortex. However, they remain distinct in the thalamus. A strong remapping of sensory responses accompanies this dynamic state change produced by anesthesia. Together, these results show that the awake cortex engages dedicated neuronal assemblies in response to sensory inputs, which we suggest is a network correlate of sensory perception. Filipchuk et al. show that when awake mice perceive sounds, the auditory cortex produces sound-specific neuronal assemblies distinct from its ongoing activity, whereas under anesthesia sound-evoked assemblies are indistinguishable from ongoing activity. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=159499951 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41593-022-01168-5 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 1327 Titles: – TitleFull: Awake perception is associated with dedicated neuronal assemblies in the cerebral cortex. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Filipchuk, Anton – PersonEntity: Name: NameFull: Schwenkgrub, Joanna – PersonEntity: Name: NameFull: Destexhe, Alain – PersonEntity: Name: NameFull: Bathellier, Brice IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 10976256 Numbering: – Type: volume Value: 25 – Type: issue Value: 10 Titles: – TitleFull: Nature Neuroscience Type: main |
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