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Predictors of methacholine challenge testing results in subjects without airflow obstruction.

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Title: Predictors of methacholine challenge testing results in subjects without airflow obstruction.
Authors: Chevrier, Stephanie (AUTHOR), Abdulnour, Joseph (AUTHOR), Saint-Pierre, Mathieu D. (AUTHOR)
Source: Journal of Asthma. Oct2022, Vol. 59 Issue 10, p2060-2068. 9p.
Subjects: Air flow, Methacholine chloride, Pulmonary function tests, Wheeze, Airway resistance (Respiration), Body mass index
Abstract: Methacholine challenge testing (MCT) is considered when asthma remains clinically suspected despite normal spirometry. Few studies have attempted to determine the predictive factors of MCT results. We aimed to establish which demographic data, clinical symptoms, pulmonary function testing results, and laboratory values were associated with abnormal MCT (provocation concentration causing a 20% decrease in FEV1 (PC20) ≤ 16 mg/mL) in subjects without airflow obstruction on spirometry. All patients who completed MCT at Montfort Hospital between January 1st, 2016 and December 31st, 2018 were identified. Subjects with a reduced FEV1/FVC ratio were excluded. We used Pearson's chi-squared test and point-biserial correlation method to determine which variables had a significant relationship (p < 0.05) with MCT results. 23.3% of patients who underwent MCT had airflow limitation. In the 1126 subjects with a normal FEV1/FVC ratio, PC20 ≤ 16 mg/mL was found in 13.0%. Younger age, female gender, body mass index ≥ 40, and reported wheezing were factors associated with increased probability of airway hyper responsiveness. Lower FEV1, significant improvement of the FEV1 post-bronchodilator, reduced FEF25%-75%, greater FEF25%-75% reversibility, airway resistance measurements above the upper limit of normal, and increased blood eosinophil counts were predictive of abnormal MCT. Only 13.0% of patients referred for MCT had a PC20 ≤ 16 mg/mL when the FEV1/FVC ratio was normal, highlighting the need to further define in which individuals this test is truly warranted. Further investigation is required to develop an easy-to-use and validated prediction model in order to better understand patients' pretest probability of abnormal MCT. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Asthma is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Predictors of methacholine challenge testing results in subjects without airflow obstruction.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Chevrier%2C+Stephanie%22&quot;&gt;Chevrier, Stephanie&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Abdulnour%2C+Joseph%22&quot;&gt;Abdulnour, Joseph&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Saint-Pierre%2C+Mathieu+D%2E%22&quot;&gt;Saint-Pierre, Mathieu D.&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Journal+of+Asthma%22&quot;&gt;Journal of Asthma&lt;/searchLink&gt;. Oct2022, Vol. 59 Issue 10, p2060-2068. 9p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Air+flow%22&quot;&gt;Air flow&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Methacholine+chloride%22&quot;&gt;Methacholine chloride&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Pulmonary+function+tests%22&quot;&gt;Pulmonary function tests&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Wheeze%22&quot;&gt;Wheeze&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Airway+resistance+%28Respiration%29%22&quot;&gt;Airway resistance (Respiration)&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Body+mass+index%22&quot;&gt;Body mass index&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Methacholine challenge testing (MCT) is considered when asthma remains clinically suspected despite normal spirometry. Few studies have attempted to determine the predictive factors of MCT results. We aimed to establish which demographic data, clinical symptoms, pulmonary function testing results, and laboratory values were associated with abnormal MCT (provocation concentration causing a 20% decrease in FEV1 (PC20) ≤ 16 mg/mL) in subjects without airflow obstruction on spirometry. All patients who completed MCT at Montfort Hospital between January 1st, 2016 and December 31st, 2018 were identified. Subjects with a reduced FEV1/FVC ratio were excluded. We used Pearson&#39;s chi-squared test and point-biserial correlation method to determine which variables had a significant relationship (p &lt; 0.05) with MCT results. 23.3% of patients who underwent MCT had airflow limitation. In the 1126 subjects with a normal FEV1/FVC ratio, PC20 ≤ 16 mg/mL was found in 13.0%. Younger age, female gender, body mass index ≥ 40, and reported wheezing were factors associated with increased probability of airway hyper responsiveness. Lower FEV1, significant improvement of the FEV1 post-bronchodilator, reduced FEF25%-75%, greater FEF25%-75% reversibility, airway resistance measurements above the upper limit of normal, and increased blood eosinophil counts were predictive of abnormal MCT. Only 13.0% of patients referred for MCT had a PC20 ≤ 16 mg/mL when the FEV1/FVC ratio was normal, highlighting the need to further define in which individuals this test is truly warranted. Further investigation is required to develop an easy-to-use and validated prediction model in order to better understand patients&#39; pretest probability of abnormal MCT. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Journal of Asthma is the property of Taylor &amp; Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/02770903.2021.1986838
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 9
        StartPage: 2060
    Subjects:
      – SubjectFull: Air flow
        Type: general
      – SubjectFull: Methacholine chloride
        Type: general
      – SubjectFull: Pulmonary function tests
        Type: general
      – SubjectFull: Wheeze
        Type: general
      – SubjectFull: Airway resistance (Respiration)
        Type: general
      – SubjectFull: Body mass index
        Type: general
    Titles:
      – TitleFull: Predictors of methacholine challenge testing results in subjects without airflow obstruction.
        Type: main
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          Name:
            NameFull: Chevrier, Stephanie
      – PersonEntity:
          Name:
            NameFull: Abdulnour, Joseph
      – PersonEntity:
          Name:
            NameFull: Saint-Pierre, Mathieu D.
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          Dates:
            – D: 01
              M: 10
              Text: Oct2022
              Type: published
              Y: 2022
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              Value: 02770903
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              Value: 59
            – Type: issue
              Value: 10
          Titles:
            – TitleFull: Journal of Asthma
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