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Eye movement abnormalities in neurodegenerative langerhans cell histiocytosis.

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Title: Eye movement abnormalities in neurodegenerative langerhans cell histiocytosis.
Authors: Autier, Lila (AUTHOR), Gaymard, Bertrand (AUTHOR), Bayen, Eléonore (AUTHOR), Del Cul, Antoine (AUTHOR), Cohen-Aubart, Fleur (AUTHOR), Martin-Duverneuil, Nadine (AUTHOR), Haroche, Julien (AUTHOR), Mokhtari, Karima (AUTHOR), Héritier, Sébastien (AUTHOR), Donadieu, Jean (AUTHOR), Hoang-Xuan, Khê (AUTHOR), Idbaih, Ahmed (AUTHOR)
Source: Neurological Sciences. Nov2022, Vol. 43 Issue 11, p6539-6546. 8p. 2 Charts, 4 Graphs.
Subjects: Langerhans-cell histiocytosis, Eye movements, Erdheim-Chester disease, Cerebellar ataxia, Square waves, Central nervous system
Abstract: Langerhans cell histiocytosis (LCH) is a rare inflammatory myeloid neoplasm characterized by proliferation of tumor histiocytes that involves multiple organs including central nervous system. The physiopathologic process underlying degenerative neuro-LCH (i.e., DN-LCH) remains imperfectly settled. Since the main clinical features of DN-LCH are cerebellar ataxia and dysexecutive syndrome, eye movements might be disrupted and may help in disease diagnosis and monitoring. We retrospectively analyzed the medical records of twenty DN-LCH patients investigated using eye movement recording (EMR) in our hospital between 2015 and 2018. DN-LCH patients exhibited (i) abnormal gain in visually guided saccades including hypermetric saccades and excessive gain variability -45.0%-, (ii) increased mean antisaccade error rates -66.7%-, (iii) altered smooth pursuit -50.0%-, and (iv) excessive number of square wave jerks-25%- and gaze-evoked nystagmus. Our study suggests that DN-LCH patients present a peculiar pattern of eye movement impairments supporting cerebellar and prefrontal dysfunctions. As a non-invasive method, EMR could therefore be a useful tool for quantitative monitoring of DN-LCH patients. Further studies are warranted to support our findings. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Eye movement abnormalities in neurodegenerative langerhans cell histiocytosis.
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  Data: <searchLink fieldCode="AR" term="%22Autier%2C+Lila%22">Autier, Lila</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gaymard%2C+Bertrand%22">Gaymard, Bertrand</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bayen%2C+Eléonore%22">Bayen, Eléonore</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Del+Cul%2C+Antoine%22">Del Cul, Antoine</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cohen-Aubart%2C+Fleur%22">Cohen-Aubart, Fleur</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Martin-Duverneuil%2C+Nadine%22">Martin-Duverneuil, Nadine</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Haroche%2C+Julien%22">Haroche, Julien</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mokhtari%2C+Karima%22">Mokhtari, Karima</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Héritier%2C+Sébastien%22">Héritier, Sébastien</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Donadieu%2C+Jean%22">Donadieu, Jean</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hoang-Xuan%2C+Khê%22">Hoang-Xuan, Khê</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Idbaih%2C+Ahmed%22">Idbaih, Ahmed</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Nov2022, Vol. 43 Issue 11, p6539-6546. 8p. 2 Charts, 4 Graphs.
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  Data: Langerhans cell histiocytosis (LCH) is a rare inflammatory myeloid neoplasm characterized by proliferation of tumor histiocytes that involves multiple organs including central nervous system. The physiopathologic process underlying degenerative neuro-LCH (i.e., DN-LCH) remains imperfectly settled. Since the main clinical features of DN-LCH are cerebellar ataxia and dysexecutive syndrome, eye movements might be disrupted and may help in disease diagnosis and monitoring. We retrospectively analyzed the medical records of twenty DN-LCH patients investigated using eye movement recording (EMR) in our hospital between 2015 and 2018. DN-LCH patients exhibited (i) abnormal gain in visually guided saccades including hypermetric saccades and excessive gain variability -45.0%-, (ii) increased mean antisaccade error rates -66.7%-, (iii) altered smooth pursuit -50.0%-, and (iv) excessive number of square wave jerks-25%- and gaze-evoked nystagmus. Our study suggests that DN-LCH patients present a peculiar pattern of eye movement impairments supporting cerebellar and prefrontal dysfunctions. As a non-invasive method, EMR could therefore be a useful tool for quantitative monitoring of DN-LCH patients. Further studies are warranted to support our findings. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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