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Longitudinal changes in behaviour, mood and functional capacity in the primary progressive aphasia variants.

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Title: Longitudinal changes in behaviour, mood and functional capacity in the primary progressive aphasia variants.
Authors: Foxe, David (AUTHOR), Irish, Muireann (AUTHOR), Ramanan, Siddharth (AUTHOR), Stark, Samuel (AUTHOR), Cordato, Nicholas J. (AUTHOR), Burrell, James R. (AUTHOR), Piguet, Olivier (AUTHOR)
Source: European Journal of Neuroscience. Nov2022, Vol. 56 Issue 9, p5601-5614. 14p. 2 Charts, 3 Graphs.
Subjects: Aphasia, Functional status, Eating disorders, Language disorders, Speech apraxia, Cognitive ability, Caregiver education
Abstract: Primary progressive aphasia (PPA) is a neurodegenerative clinical syndrome characterised by a progressive decline in speech and language functions. Deficits in behaviour, mood and functional capacity are reported in PPA but are less well understood. This study examined the PPA variants' profiles on these domains at initial presentation and over time and evaluated their relations to overall cognitive ability. Behaviour, mood and functional capacity were measured annually (over ~6 years) in 145 individuals diagnosed with PPA (41 logopenic [lv‐PPA], 44 non‐fluent [nfv‐PPA] and 60 semantic variants [sv‐PPA]) using the Cambridge Behavioural Inventory‐Revised (CBI‐R) carer questionnaire. Overall cognition was assessed annually with the Addenbrooke's Cognitive Examination‐III. Distinct profiles were observed across PPA syndromes. Notably, sv‐PPA carers reported greater behavioural, eating and motivational disturbances than the other PPA variants throughout the disease course. Reported memory problems were also greater in sv‐PPA and lv‐PPA than in nfv‐PPA across all time points. These disturbances occurred in the context of the sv‐PPA group demonstrating a slower rate of cognitive decline than the lv‐PPA group and a parallel rate to that found in the nfv‐PPA group. Associations between overall cognition and the CBI‐R domains were trivial at baseline assessment; however, distinct profiles emerged when mapping each syndrome's overall cognitive decline with their behavioural, mood and functional trajectories. Our findings demonstrate that the evolving behaviour, mood and functional capacity profiles of the PPA variants are distinct and extend beyond the primary disorder of language. These findings have important implications for clinical management and caregiver education in PPA. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
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  Data: Longitudinal changes in behaviour, mood and functional capacity in the primary progressive aphasia variants.
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  Data: <searchLink fieldCode="AR" term="%22Foxe%2C+David%22">Foxe, David</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Irish%2C+Muireann%22">Irish, Muireann</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ramanan%2C+Siddharth%22">Ramanan, Siddharth</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stark%2C+Samuel%22">Stark, Samuel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cordato%2C+Nicholas+J%2E%22">Cordato, Nicholas J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Burrell%2C+James+R%2E%22">Burrell, James R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Piguet%2C+Olivier%22">Piguet, Olivier</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Nov2022, Vol. 56 Issue 9, p5601-5614. 14p. 2 Charts, 3 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Aphasia%22">Aphasia</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+status%22">Functional status</searchLink><br /><searchLink fieldCode="DE" term="%22Eating+disorders%22">Eating disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Language+disorders%22">Language disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Speech+apraxia%22">Speech apraxia</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+ability%22">Cognitive ability</searchLink><br /><searchLink fieldCode="DE" term="%22Caregiver+education%22">Caregiver education</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Primary progressive aphasia (PPA) is a neurodegenerative clinical syndrome characterised by a progressive decline in speech and language functions. Deficits in behaviour, mood and functional capacity are reported in PPA but are less well understood. This study examined the PPA variants' profiles on these domains at initial presentation and over time and evaluated their relations to overall cognitive ability. Behaviour, mood and functional capacity were measured annually (over ~6 years) in 145 individuals diagnosed with PPA (41 logopenic [lv‐PPA], 44 non‐fluent [nfv‐PPA] and 60 semantic variants [sv‐PPA]) using the Cambridge Behavioural Inventory‐Revised (CBI‐R) carer questionnaire. Overall cognition was assessed annually with the Addenbrooke's Cognitive Examination‐III. Distinct profiles were observed across PPA syndromes. Notably, sv‐PPA carers reported greater behavioural, eating and motivational disturbances than the other PPA variants throughout the disease course. Reported memory problems were also greater in sv‐PPA and lv‐PPA than in nfv‐PPA across all time points. These disturbances occurred in the context of the sv‐PPA group demonstrating a slower rate of cognitive decline than the lv‐PPA group and a parallel rate to that found in the nfv‐PPA group. Associations between overall cognition and the CBI‐R domains were trivial at baseline assessment; however, distinct profiles emerged when mapping each syndrome's overall cognitive decline with their behavioural, mood and functional trajectories. Our findings demonstrate that the evolving behaviour, mood and functional capacity profiles of the PPA variants are distinct and extend beyond the primary disorder of language. These findings have important implications for clinical management and caregiver education in PPA. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/ejn.15557
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              Text: Nov2022
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              Y: 2022
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