View in EDS HTML Full Text PDF Full Text

Role of proline‐rich tyrosine kinase 2 (Pyk2) in the pathogenesis of Alzheimer's disease.

Saved in:
Bibliographic Details
Title: Role of proline‐rich tyrosine kinase 2 (Pyk2) in the pathogenesis of Alzheimer's disease.
Authors: Kumar, Rahul (AUTHOR), Tiwari, Vishvanath (AUTHOR), Dey, Sharmistha (AUTHOR)
Source: European Journal of Neuroscience. Nov2022, Vol. 56 Issue 9, p5442-5452. 11p. 1 Color Photograph.
Subjects: Protein-tyrosine kinases, Alzheimer's disease, Kinases, Focal adhesion kinase, Proline, Neurofibrillary tangles
Abstract: Alzheimer's disease (AD), a progressive neurodegenerative disorder, is the most common form of dementia in the elderly. Two major pathological hallmarks have been identified for AD: extracellular amyloid plaques and intracellular neurofibrillary tangles (NFT). Recently, proline‐rich tyrosine kinase 2 (Pyk2), which belongs to the focal adhesion kinase (FAK) non‐receptor tyrosine kinase family, was recognized to contribute significantly towards the pathogenesis of AD. Pyk2 can influence the formation of amyloid plaques as well as NFTs. The kinase can directly phosphorylate tau, which is a significant component of NFTs and enhances tau pathology. Several competitive inhibitors have been developed for Pyk2, tested in several cancer models, as Pyk2 is known to be overexpressed under those conditions. The current review article discusses the possible mechanistic pathways by which Pyk2 can influence the pathogenesis of AD. Besides, it describes various inhibitors for Pyk2 and their potential role as therapeutics for AD in the future. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 160176901
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Role of proline‐rich tyrosine kinase 2 (Pyk2) in the pathogenesis of Alzheimer's disease.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Kumar%2C+Rahul%22">Kumar, Rahul</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tiwari%2C+Vishvanath%22">Tiwari, Vishvanath</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dey%2C+Sharmistha%22">Dey, Sharmistha</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Nov2022, Vol. 56 Issue 9, p5442-5452. 11p. 1 Color Photograph.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Protein-tyrosine+kinases%22">Protein-tyrosine kinases</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+disease%22">Alzheimer's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Kinases%22">Kinases</searchLink><br /><searchLink fieldCode="DE" term="%22Focal+adhesion+kinase%22">Focal adhesion kinase</searchLink><br /><searchLink fieldCode="DE" term="%22Proline%22">Proline</searchLink><br /><searchLink fieldCode="DE" term="%22Neurofibrillary+tangles%22">Neurofibrillary tangles</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Alzheimer's disease (AD), a progressive neurodegenerative disorder, is the most common form of dementia in the elderly. Two major pathological hallmarks have been identified for AD: extracellular amyloid plaques and intracellular neurofibrillary tangles (NFT). Recently, proline‐rich tyrosine kinase 2 (Pyk2), which belongs to the focal adhesion kinase (FAK) non‐receptor tyrosine kinase family, was recognized to contribute significantly towards the pathogenesis of AD. Pyk2 can influence the formation of amyloid plaques as well as NFTs. The kinase can directly phosphorylate tau, which is a significant component of NFTs and enhances tau pathology. Several competitive inhibitors have been developed for Pyk2, tested in several cancer models, as Pyk2 is known to be overexpressed under those conditions. The current review article discusses the possible mechanistic pathways by which Pyk2 can influence the pathogenesis of AD. Besides, it describes various inhibitors for Pyk2 and their potential role as therapeutics for AD in the future. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=160176901
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/ejn.15569
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 11
        StartPage: 5442
    Subjects:
      – SubjectFull: Protein-tyrosine kinases
        Type: general
      – SubjectFull: Alzheimer's disease
        Type: general
      – SubjectFull: Kinases
        Type: general
      – SubjectFull: Focal adhesion kinase
        Type: general
      – SubjectFull: Proline
        Type: general
      – SubjectFull: Neurofibrillary tangles
        Type: general
    Titles:
      – TitleFull: Role of proline‐rich tyrosine kinase 2 (Pyk2) in the pathogenesis of Alzheimer's disease.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Kumar, Rahul
      – PersonEntity:
          Name:
            NameFull: Tiwari, Vishvanath
      – PersonEntity:
          Name:
            NameFull: Dey, Sharmistha
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 11
              Text: Nov2022
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-print
              Value: 0953816X
          Numbering:
            – Type: volume
              Value: 56
            – Type: issue
              Value: 9
          Titles:
            – TitleFull: European Journal of Neuroscience
              Type: main
ResultId 1